I Am Addicted To Metformin?!

[Smont]

What’s best alternative??

In my opinion it's berberine, lots of ppl like it better then metformin

 

[semtex]

Some research sites sell metformin

 

[booneman77]

What’s best alternative??

berberine. like 204582409 ppl already said. bye.

 

[Smont]

Some research sites sell metformin

Really? I'm surprised that flies under the radar

 

[Jrizzy50.]

I’d be interested lol

 

[semtex]

Really? I'm surprised that flies under the radar

I've only seen it at one research chem site so far but it says it's sold out. it's not one that I normally order from so who knows if it's legit or even real metformin. I usually stick to board sponsors.

 

[NoAddedHmones]

Again no need to fear it, its mostly internet rumors.

Metformin activates an isoform of AMPK which is NOT inhibitory to mTORC1:

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance - Journal of the International Society of Sports Nutrition

The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) plays a pivotal role in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to phosphorylation of two important sets of substrates, namely eIF4E binding proteins and ribosomal S6 kinases...

jissn.biomedcentral.com

"Additionally, only the α1-containing heterotrimer appears to attenuate muscle growth, whereas the α2-containing heterotrimers do not appear to do so [60]."
It activates an a2-containing one in skeletal muscle, which is involved in (glucose) metabolism, and not inhibitory to mTORC1.


I've been taking metformin for 5 yesrs and GDA's supplements for over decades and I can tell you after adding Metformin I see zero negative in my physique development. Obvious this is an n=1 but if I saw even a hair of negative I'd freak out and stop. Have not and only seen good things especially with carbohydrate tolerance.

That study doesn’t even talk about metformin?

Besides https://pubmed.ncbi.nlm.nih.gov/20844250/

It clearly increases the alpha(1) subunit not alpha(2)

Not to mention its negative effects on the HPTA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199060/

Need to differentiate its effects/benefits with a healthy vs pathological state.

 

[NoAddedHmones]

Double

 

[KingErgogenic]

That study doesn’t even talk about metformin?

Besides https://pubmed.ncbi.nlm.nih.gov/20844250/

It clearly increases the alpha(1) subunit not alpha(2)

Not to mention its negative effects on the HPTA: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199060/

Need to differentiate its effects/benefits with a healthy vs pathological state.

That's in women...

 

[NoAddedHmones]

That's in women...

Good call. I copied the wrong link.

https://www.researchgate.net/publication/11156121_Effects_of_short_term_metformin_administration_on_androgens_in_normal_men

 

[KingErgogenic]

Good call. I copied the wrong link.

https://www.researchgate.net/publication/11156121_Effects_of_short_term_metformin_administration_on_androgens_in_normal_men

Metformin 850 mg twice daily - Thats a pretty big dose. I was using max 500mg once a day.

Never noticed any symptoms of low testosterone, but that's because mine is naturally insanely high.

 

[jtbull]

So many of you probably already know who I am, but for those who don't, I am that guy who maxed his Testosterone naturally:

You can check my thread on it here:
I Made My Testosterone Off The Scale High - Men's Health

Anyway, getting to the point of this post.

I started taking metformin after (ab)using Cyproheptadine for many months.

I first started dosing at 500mg XR form, usually with my biggest carb meal in the evenings.

I didn't really notice much at the start, apart from slightly reduced appetite.

2 weeks later these are the key effects I had noticed from
regularly taking 250mg-500mg of XR Metformin whilst on a high carb diet:
-INSANE muscle pumps, to the point of almost feeling like veins were gonna pop.
-Improved gym performance.
-Leaner physique.
-Reduced appetite.
-Better cortisol awakening response (Did you know that metformin can do what licorice does with cortisol?)
-Easier to fast if I had to.

Obviously I am aware of the side effects of metformin use:
-B12 Deficiency (Currently supplementing to offset)
-Homocysteine issues (Taurine to offset)
-Raises cortisol (I need this).

But what makes me feel "Addicted to it"


THE PUMPS!!!

No other GDA has come close. If anyone has any other natural botanical or any other compound that can match this I will be impressed.


Cheers.

what does licorice do to cortisol? Is this similar to insulin?

 

[diesel x]

So many of you probably already know who I am, but for those who don't, I am that guy who maxed his Testosterone naturally:

You can check my thread on it here:
I Made My Testosterone Off The Scale High - Men's Health

Anyway, getting to the point of this post.

I started taking metformin after (ab)using Cyproheptadine for many months.

I first started dosing at 500mg XR form, usually with my biggest carb meal in the evenings.

I didn't really notice much at the start, apart from slightly reduced appetite.

2 weeks later these are the key effects I had noticed from
regularly taking 250mg-500mg of XR Metformin whilst on a high carb diet:
-INSANE muscle pumps, to the point of almost feeling like veins were gonna pop.
-Improved gym performance.
-Leaner physique.
-Reduced appetite.
-Better cortisol awakening response (Did you know that metformin can do what licorice does with cortisol?)
-Easier to fast if I had to.

Obviously I am aware of the side effects of metformin use:
-B12 Deficiency (Currently supplementing to offset)
-Homocysteine issues (Taurine to offset)
-Raises cortisol (I need this).

But what makes me feel "Addicted to it"


THE PUMPS!!!

No other GDA has come close. If anyone has any other natural botanical or any other compound that can match this I will be impressed.


Cheers.

metformin lowers igf1 levels, its terrible for bodybuilding

 

[Derek Wilson]

Metformin use is rampant among bodybuilders. Don't worry its fine.

Thanks for the exact info!

 

[justhere4comm]

Also, bodybuilders use an insane amount of steroids, unlike many in here so metformin may not effect them like it does us.
They are using HGH in super physiological ranges on top of it.

 

[Smont]

metformin lowers igf1 levels, its terrible for bodybuilding

If your on gear it won't really make a difference, for a natural bodybuilder, ya it's probably not the best idea

 

[diesel x]

If your on gear it won't really make a difference, for a natural bodybuilder, ya it's probably not the best idea

if you do it consistently even on gear it will make a difference ive seen bloodwork

 

[Smont]

if you do it consistently even on gear it will make a difference ive seen bloodwork

I'm sure it will make a difference, but, there are also plenty of people who use metformin year round with large amounts of muscle. The steroids are going to raise your igf levels more then metformin is going to drop it. Maybe not at trt doses but on cycle I would not be worried in the slightest. At the end of the day, everyone needs to see what will and will not work for them. I'm not advocating everyone to run out and get on metformin, if you need it, and are on it, it's not going to make all your muscles dissapear or completely stop you from building muscle.

 

[KingErgogenic]

what does licorice do to cortisol? Is this similar to insulin?

Licorice spares cortisol. Prevents it from breaking down and increases its active form.