HUNG* Writeup

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Still need a new name and a full edit, but I promised today.......


HUNG





We are delving into a deceptively complicated subject here. One that has eluded my mastery for going on 2 decades, and that is just now coalescing into a masterpiece. I’m sure that in the coming years our understanding will increase even more, allowing for updates.





Goal/Product Statement:





HUNG is designed as a correlary product to be used with exercise/stretching stimulus to amplify body response, healing, and ultimately increases in not only length and girth, but healthy function through vascular remodeling and restoration of youthful NO response and smooth vascular muscle dilation/contraction to optimize blood flow for ideal erectile response.





NOTE: This product will not be effective if you do not employ physical stimulus – stretching via jelqing and/or traction, pumping, heating, Infra-red, etc. HUNG simply activates/inhibits key pathways to allow for maximum recovery and protein/tissue synthesis.





OK, now to the good stuff. This is a rough draft meant to outlay the pathways and give a summary.





1. PROSTAGLANDINS


Prostaglandins are some of the most ancients stimulus/response pathways in existences, traversing almost all species – especially mammalian. They are named because they were first isolated in prostate glands. They cause rapid and powerful responses to injury/workouts, play key roles in estrous and fertility as well as labor induction. First though to be reproductive only, they are now understood to be a huge part of every tissue in the body. The ones we will focus on are the 2 series, mostly PGF2a and the 1 series (PGE1)





For all prostaglandins, incorporation of fatty acids and phospholipids in the cellular mebranes and strategic response release to various stimuli are key.





1a. PGF2a





Those familiar with my, and others’, work will already be familiar with this pathway. Arachidonic Acid (ArA)content, the primary precursor, can be increased in the cellular mebranes – especially in the different muscle types. Subsequently stimuli, such as lifting weights and other types of “injury”, stretching, etc – basically anything that causes sudden deformation and perturbation of the membrane- cause the ArA to be released from captivity in the membrane and interact with PhosphoLipase A2, and subsequently COX-2 to form the 2 series prostaglandins. The one we are interested in is PGF2a, an extremely potent and fast acting healing stimulus. PGF2a communicates with adjacent cells triggering a sort of outward communication and feed forward loop which then triggers inflammation, upregulation of pain (to discourage you from further injuring the area), and a rapid induction of the Insulinlike Growth Factor1 pathway resulting in tissue repair and growth. There are some correlary factors that optimize using this pathway.





Note: COX-2 is the enzyme inhibited by NSAIDs such as ibuprofen. BY preventing the formation of the 2 series prostaglandins, the pain/inflammatory response is blunted, preventing paid.





1a1. Beta-Escin





Beta-Escin is a fascinating compound. The primary active compound in Horse Chestnut, used for centuries to prevent vascular leakage, Beta-Escin, when it comes into contact with cells, causes tiny pore/inury to the membranes, thus releasing the ArA and setting into motion the process described above. By not relying exclusively on the mechanical (workout, etc) we get an amplified injury response.





1a2. TRPV (1 and 4)





The Transient Receptor Potentials are extremely complicated and far beyond the scope of this, but are generally environmental sensors. TRPV1 essentially being both a HIGH temperature sensor as well as noxious chemical sensor, it is most well know as the primary receptor activated by Capsaicin (Hot Peppers). The signal resembles a burn injury (which in our usage is only an illusion – no actual tissue damage being done) which then goes on to trigger the body to deploy their quick response for the “heal” the injury, resulting in an anabolic response. We are using a non-painful ingredient, Stearoyl Vannilylamide, to stimulate the TRPV1 receptor without pain. Pain down there sucks.





TRPV4, on the other hand, reacts strongly to stretch stimulus – exactly what we will be using to stimulate increases in size and girth. Not only does it amplify the signal, it also amplifies the repair response of protein synthesis. To stimulate TRPV4, I have developed some ultra pure Andrographolide-Nicotinamide cocrystals for better absorption.





2. PGE1





PGE1 is fascinating. Derived from not Ara, but from Gamma Linolenic Acid. The pathway is GLA-→Dihomo-GLA → PGE1





PGE1 (in its pure form) has been used for decades as a direct into penis injection that causes rapid and powerful erections. Turns out by using the GLA (and hopefully DHGLA eventually) to again saturate the membranes similar to ArA, we can cause amazing vasorelaxation, which allows more blood and nutrients into the tissue and keeps erectile response healthy.





2. Phosphatidic Acid





I’m going to this ingredient next because the process is similar to the above. PA activates a pathway called mTOR, which is THE main pathway involved in protein synthesis. In a serendipitous process crossover, the PGF2a release via Beta-Escin, we will also be triggering the localized release of PA, which will immediately cause protein synthesis in the penile tissue. Being a phospholipid, cellular mebranes LOVE it and will suck it up like...well, never mind (wink wink).
 
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3. Estrogen Receptor beta





Shush. I know your first reaction is going to be “Keep that estrogen away from my little, soon to be BIG buddy. Well relax. Many recent studies have shown that Erb in actually essential for muscle growth (as in blocking Erb activation will prevent all training adaptations) and without it you out of luck. Erb actually serves as a balance to, and blocker of, excessive Estrogen Receptor Alpha effects – which are mostly undesirable in males.





In order to make this work we have 2 hurdles. First, we need an exclusive Erb agonist. Second, we need it to absorb. Well, we got it handled here. Using an exceptionally pure Genistein, formed into a (quite beautiful, if I do say so myself) cocrystal with Nicotinamide (will cover later why I used this as coformer), we have maximized solubility and absorption. Pretty simple, really. Trust me.








4. Androgen-Receptor-Enzyme interactions





The penis is a bustling metropolis when it comes to sex hormones, receptors, and enzymes which interconvert the hormones to more powerful and less powerful forms.





1a. 3-AD


In the penis, the tissue responds mostly to extremely androgenic (if less anabolic) hormones. 3-AD is a very potent pure androgen. By making the carrier a version of my extremely effective localised liposomal, we are able to deliver, and keep, the topically delivered androgen restricted to the penile tissue.





1b. Gibberellic Acid





As well, in miniscule amounts to avoid side effects, the plant growth regulator GA does an amazing job of increasing the activity of both 3b-HSD and 17b-HSD, which are both required to turn weaker androgens already existing in the penis (DHEA, etc) into more potent forms, thus taking a more natural angle.





1c. Propionyl-L-Carnitine





First released by yours truly back in 2004 or so, PLCAR is an amazing coound that I am still working on to make a more market friendly product. The various forms of Carnitine (tartarate, but problems with topical delivery), including PLCAR are very effective increasing the number of androgen receptors. More receptors, more potent activity. Simple.





5. Myostatin





Myostatin we have probably all heard of by now for skeletal muscle. While it has sort of a similar role in the smooth muscle of the penis, the worst thing it does it cause something called Fibrosis. When previously pliable and healthy tissue undergoes fibrosis, the tissue hardens and becomes less functional. For example, Peyronie’s disease is a disorder of Fibrosis, where one side of the penis is restricted and less “stretchy” causing that side to resist expansion-erection and pull that one side down, causing dramatic curvature.





1a. Epicatechin I first brought isolated epicatechin to the market with my Myosynergy product, and while I am still ugrading to make it work more effectively orally, I will be using my latest advancement in HUNG. The problem with Epicatechin? It has virtually ZERO solubility. In anything. No solubility? No absorption. Well, using a mixtures of solvents, I was able to get Epicatechin to for a chemical bond to Apigenin – another great ingredient with low solubility. The two compounds form into a bonded “cocompound” (waiting for verification whether we get a full cocrystal or not), which then strangely enables both to dissolve. The addition of a small amount of AlphaTerpineol to the carrier increases absorption several fold.








1b. Apigenin


Apigenin is a citrus flavonoid that has potent effects in the body (IF you get absorption) including for our purposes increases in testicular steroidogenesis and vascular restoration.








6. Smooth muscle and spongy tissue relaxation





The penis is a strange organ. Only by RELAXING certain muscle and tissues are we able to achieve erection. Think the opposite of the anal sphincter. In the formula, I am using an amazing compound called Bacalein. Bacalein induces tremendous relaxation in the Corpus Cavernosum, the primary smooth muscle/spongy blood filled tissues of the penis responsible for erectile rigidity and size. Having horrid solubility...again...Bacalein forms beautiful cocrystals with Ascorbuc Acid (vitamin c) which also contributes to preventing ROS and RNS damage.





7. PTP1b





1a. I have to keep this one simple, being one of the most complicated angles. PTP1b is a ubiquitous enzyme in the body, related to Leptin resistance, Insulin Resistance, and development of vascular plaques which can lead to Atherosclerosis. Truly a miracle discovery, inhibiting PTP1b results in restoration of both tissue and vascular response. There have been some studies showing perfect vascular clearance of plaques in only a few days. Obviously restoring vascular function is a critical angle in this product...and once again we have an ingredient with wretched solubility. Our incredible ingredient is Betulinic Acid, and our coformer is once again Ascorbic Acid. The formation of this cocrystal increases solubility over 17 fold. Inhibition of PTP1b has also been shown to cause a stunning increase in smooth muscle proliferation and Vascular Endothelial Growth Factor. That one should be a no-brainer.





8. Carrier





The specialized carrier took me many years to perfect, designed to keep the ingredients isolated as much as possible to the area applied. While not getting too detailed lest someone less scrupulous attempt to copy, what I will say is that as a liposomal stabilizer ( usually cholesterol is used) we are using phytosterol (structurally resembling Cholsterol). Some studies in children have demonstrated early induction of puberty, especially in males, with very notable effects showing in penis growth. Honestly, there’s not a huge number of studies but I figured I would mention it.
 
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Let me edit the spacing and I will post everything on the store product page.
 

Jeremyk1

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Would this work as a replacement for Top Muscle? I noticed there is a little overlap.
 
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Would this work as a replacement for Top Muscle? I noticed there is a little overlap.
Different carrier. Some overlap.

I would just wait for the TopMuscle update in a few weeks.
 

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