Invalid Link Removed
(Liothyrine Sodium )
This drug is a synthetic Invalid Link Removed Invalid Link Removed . As you may already know, most natural Invalid Link Removed is not produced directly by your thyroid gland, but rather is converted from the T4 thyroid Invalid Link Removed . (8)
Natural Invalid Link Removed is a regulator of the oxidative metabolism of energy producing substrates (food or stored substrates like fat, muscle, and glycogen) by the mitochondria. The mitochondria, as you will recall from your high school biology class, are usually referred to as the "cell's powerhouses" because they produce ATP. Taking Invalid Link Removed (supplemental Invalid Link Removed ) greatly increases the uptake of nutrients into the mitochondria and also their oxidation rate (i.e. the rate at which they are burned for energy), by increasing the activities of the enzymes involved in the oxidative metabolic pathway. Everything is working harder, in other words, and more fuel is needed to Invalid Link Removed this increased work rate. Therefore, as you can guess, taking supplemental Invalid Link Removed will increase your body’s energy demands. And if you are in a hypocaloric state, you will begin burning even more fat primarily due to an increase in ATP. This increased ATP causes an increase in overall metabolic activity. (8)(9)This is exactly what we want, and is why we would be taking thyroid hormones like Invalid Link Removed in the first place. If you aren’t taking Invalid Link Removed Invalid Link Removed with your Invalid Link Removed , however, your body may start to eat away muscle to provide energy for you to function. Remember mitochondria/ATP aren’t very picky, but they are very efficient. What I mean by this is that they will use whatever is on hand to generate energy for your body to continue functioning…fat, Invalid Link Removed , glucose….it doesn’t matter to ATP, as long as there’s something to give them energy. Taking this drug will increase their need to find something to burn to create this energy. Ergo, if we aren’t taking Invalid Link Removed Invalid Link Removed while taking our Invalid Link Removed , we may lose too much muscle, especially while dieting.
Thus we can see that there are many advantages to using Invalid Link Removed to optimize our metabolic rate. It will also increase your body’s ability to synthesize Invalid Link Removed , but from what I’ve seen personally, it acts as a catabolic when it isn’t administered with Invalid Link Removed Invalid Link Removed . It is often the last thing added into a precontest Invalid Link Removed , as it has a reputation for getting rid of the last few percentages of bodyfat…the “sticky fat” as it’s called in Invalid Link Removed …the fat that just doesn’t want to leave you in the last few weeks of dieting. I think this is a poor use for this drug, and that it should be the first thing added into a Invalid Link Removed to lose fat, as it will optimize your metabolic rate, which should be done at the outset of a Invalid Link Removed , not after the calorie restriction has diminished your thyroid output and you are adding it in simply to replace what was lost.
Unfortunately, in all of the studies I’ve seen, Invalid Link Removed also increased growth Invalid Link Removed production. (5)(6) As we all know, GH is also a strongly lipolytic compound, and this is another mechanism by which Invalid Link Removed may exert it’s effects, although I suspect this would only be a small percentage of it’s overall effects. This being the case, it has always been somewhat problematic to me to note that when GH and Invalid Link Removed are used together, the increased nitrogen retention normally found with GH use is negated. (7). If you were only using Invalid Link Removed and GH this may be a problem, but as I’ve already stated, you are going to need some Invalid Link Removed agents if you are using Invalid Link Removed . And as you have read previously, I recommend the veritable Invalid Link Removed /lipolytic orgy of Invalid Link Removed , Invalid Link Removed , Invalid Link Removed Invalid Link Removed , GH, and Invalid Link Removed , for 100% maximum results in minimal time
On the brighter side, and of special note to dieters, administration of Invalid Link Removed has been shown to upregulate the beta 2 receptors in fat tissue. As you know Invalid Link Removed and similar compounds downregulate this receptor, so using Invalid Link Removed with your Invalid Link Removed will help stave off or reverse this downregulation. (1)(2)(3)(4). I would still recommend taking your benadryl every third week, though.
Finally, I would like to address the issue of recovery of your natural thyroid function after you stop taking Invalid Link Removed . The horror stories of people on permanent thyroid repla***ent just aren’t true. I remember a few years ago, the rumor was circulating that the current Ms.Fitness had permanently shut off her thyroid gland, and was now fat and on thyroid Invalid Link Removed permanently. This is just another horror story based in nothing but conjecture and rumour…the studies I’ve looked at have shown people recovering their thyroid Invalid Link Removed relatively quickly (within months, at most) after going off of several YEARS (!) of thyroid repla***ent therapy (10)(11). I speculate that you can optimize your metabolic rate with Invalid Link Removed for 9-10 months a year, and just normalize yourself for 2-3 months (perhaps the winter, when you are mostly covered up), and then go right back on. Some people in the studies I read were on Invalid Link Removed for 30 years and recovered their natural thyroid function within a few months. It is however important to reduce the amount of Invalid Link Removed as you come off of it. I think we can safely spend an athletic career using Invalid Link Removed 9-10 months out of the year, and just taking those few months off to normalize ourselves. Is this aggressive? Yes. Unsafe? NO.
References:
1. Catecholamines inhibit Ca(2+)-dependent proteolysis in rat skeletal muscle through beta(2)-adrenoceptors and cAMP. Navegantes LC, Resano NM, Migliorini RH, Kettelhut IC Am J Physiol Endocrinol Metab 2001 Sep;281(3):E449-54
2. Regulation of human adipocyte gene expression by thyroid Invalid Link Removed J Clin Endocrinol Metab 2002 Feb;87(2):630-4 Viguerie N, Millet L, Avizou S, Vidal H, Larrouy D, Langin D.
3. Alpha 2- and beta-adrenergic receptor binding and action in gluteal adipocytes from patients with hypothyroidism and hyperthyroidism Metabolism 1987 Nov;36(11):1031-9 Richelsen B, Sorensen NS
4. Regulation of beta 1- and beta 3-adrenergic agonist-stimulated lipolytic response in hyperthyroid and hypothyroid rat white adipocytes Br J Pharmacol 2000 Feb;129(3):448-56. Germack R, Starzec A, Perret GY
5. Role of thyroid Invalid Link Removed in the control of growth Invalid Link Removed gene expression Braz J Med Biol Res 1994 May;27(5):1269-72. Volpato CB, Nunes MT.
6. Low-dose T(3) improves the bed rest model of simulated weightlessness in men and women. Am J Physiol 1999 Aug;277(2 Pt 1):E370-9 Lovejoy JC, Smith SR, Zachwieja JJ, Bray GA, Windhauser MM, Wickersham PJ, Veldhuis JD, Tulley R, de la Bretonne JA.
7. Effects of long-term growth Invalid Link Removed (GH) and triiodothyronine (Invalid Link Removed ) administration on functional hepatic nitrogen clearance in normal man. Wolthers T, Grofte T, Moller N, Vilstrup H, Jorgensen JO.
J Hepatol 1996 Mar;24(3):313-9
8. Human Anatomy and Physiology, 6th Edition. John w. Hole jr.
9. Physicians Desk Reference
10. Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy. N Engl J Med 1975 Oct 2;293(14):681-4 Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH.
11. Patterns off recovery of the hypothalamic-pituitary-thyroid axis in patients taken of chronic thyroid therapy. J Clin Endocrinol Metab 1975 Jul;41(1):70-80 Krugman LG, Hershman JM, Chopra IJ, Levine GA, Pekary E, Geffner DL, Chua Teco GN
