Hordenine becoming cancer-causing nitrosamines?

[sufficient_page]

Hello all,

I had seen hordenine being added to nootropic supplements, but some scientific papers indicate hordenine can easily become a cancer-causing nitrosamine

https://onlinelibrary.wiley.com/doi/10.1002/j.2050-0416.1981.tb04028.x

https://pubs.acs.org/doi/10.1021/jf00064a033

https://onlinelibrary.wiley.com/doi/pdf/10.1002/j.2050-0416.1986.tb04373.x

Can people here with more scientific training tell whether hordenine can become cancer-causing chemicals in the human body? If so, should hordenine be avoided?

 

[Jeremyk1]

It doesn’t seem like this should be much of an issue with supplements. These seem to only reference malting and brewing barley. That third reference says that the only major source of nitrosation is the kilning of the barley.

 

[sufficient_page]

It doesn’t seem like this should be much of an issue with supplements. These seem to only reference malting and brewing barley. That third reference says that the only major source of nitrosation is the kilning of the barley.

thanks for the explanation! too bad it appears FDA had banned hordenine in supplements and I did not know until now. sad

 

[N2ofusion]

It’s still widely available though

 

[sufficient_page]

It’s still widely available though

Where would be a good trustworthy source of it?

 

[N2ofusion]

Liftmode barley malt extract, which is standardized for hordenine and then you can dose appropriately.

The FDA only warned over synthetic hordenine, no issues with a natural extract.

 

[sufficient_page]

Liftmode barley malt extract, which is standardized for hordenine and then you can dose appropriately.

The FDA only warned over synthetic hordenine, no issues with a natural extract.

I did look into liftmode, sadly it's been out of stock forever now