High Volume + Alphamine

PJLFit

New member
So I went to (examine . com/supplements/agmatine) and I was looking to see if there would be any negative interactions. What I found was this:

(copied from the Examine . com link)
Does Not Go Well With
L-Arginine and L-Citrulline (for some neurological effects; cardiovascular interactions not well elucidated)
Yohimbine and Rauwolscine (Agmatine activates the α2A receptor that these inhibit)
D-Aspartic Acid due to reducing signalling via the NMDA receptors
Alcohol coingestion (may increase ulceration from alcohol)
Creatine (on the assumption that creatine positively influences NMDA signalling, agmatine works in the opposite manner at the same site; they should not be antagonstic for muscle growth or nitric oxide boosting)

Now, I'm wondering, what is the deal with this? Alphamine has Yohimbine, and High Volume combines L-Citrulline and Agmatine. I purchased High Volume yesterday and it's coming to my house today. I was going to use Alphamine + High Volume. Anyone know what the real facts are and if this combo is fine?
 
I think you will be fine taking these two together. I love both of them! I personally haven't used them at the same time though.
 
PJLFit said:
So I went to (examine . com/supplements/agmatine) and I was looking to see if there would be any negative interactions. What I found was this:

(copied from the Examine . com link)
Does Not Go Well With
L-Arginine and L-Citrulline (for some neurological effects; cardiovascular interactions not well elucidated)
Yohimbine and Rauwolscine (Agmatine activates the α2A receptor that these inhibit)
D-Aspartic Acid due to reducing signalling via the NMDA receptors
Alcohol coingestion (may increase ulceration from alcohol)
Creatine (on the assumption that creatine positively influences NMDA signalling, agmatine works in the opposite manner at the same site; they should not be antagonstic for muscle growth or nitric oxide boosting)

Now, I'm wondering, what is the deal with this? Alphamine has Yohimbine, and High Volume combines L-Citrulline and Agmatine. I purchased High Volume yesterday and it's coming to my house today. I was going to use Alphamine + High Volume. Anyone know what the real facts are and if this combo is fine?
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I have used the alphamine + high volume combo many times as well as each product by themselves pre workout. While I don't have the science facts, from my experiences I have not noticed any decreased effectiveness or negative effects from using them together.
 
The combo is beautiful, don't stress.

Agmatine is only being noted to "potentially" have interactions in those instances, this was clarified for us before by mr.cooper69 that agmatine's actions are not contradictory to these ingredients,
The MoA at the A2 receptor is quite different.

For the L-cit, arginine(dose is not high on this in HV), and agmatine:
This is always going to be noted as if you combine too many NO or vasodilator ingredients together there can be issues; but we formulated this quite safely and not dosed near high enough to be of any concern.

Are you using DAA? Not in either of these. Also I wouldn't be concerned. Some T-booster products intentionally combine these, used many times without issue

Don't drink alcohol pre workout, that dodges that bullet, lol.

Creatine will not lose any effectiveness, nor would agmatine, irregardless of NMDA signalling.
Again not in either product, if concerned you can use the creatine at another time
 
Driven2lift said:
The combo is beautiful, don't stress.
Click to expand...


Thank you so much for the detailed response. I really appreciate it. I took them separately yesterday just in case. I can tell you for sure, that High Volume is absolutely amazing and I will be purchasing again. Although, the blue frost flavor wasn't that great. I guess I'm just used to my RL flavored Alphamine. Going to use the Alpha + HV combo today :-)
 
I'm a huge fan of our cotton candy HV, it also mixes nice with both RL and FP alphamine, in my opinion
 
Looks like everyone already has this answered but I just thought I would rep PES a little more by saying that this is an awesome stack! Especially when cutting (the High Volume helps with a pump a ton if you are carb depleted). Good stuff!
 
I've been through two bottles of High Volume and I really like the stuff. About 12 days ago I started stacking it with Alphamine and I really enjoy this preworkout combo so far.

I did screw up my flavor combo today though. Opened my third bottle of HV which is Blue Frost and I did not enjoy the taste mixed with Alphamine Fruit Punch. Last two HV bottles were Paradise Cooler which tasted awesome by itself as well as mixed with my Alphamine.

I'll tough it out but my next bottle of HV will definitely go back to the Paradise Cooler...
 
dontsweatme said:
I've been through two bottles of High Volume and I really like the stuff. About 12 days ago I started stacking it with Alphamine and I really enjoy this preworkout combo so far.

I did screw up my flavor combo today though. Opened my third bottle of HV which is Blue Frost and I did not enjoy the taste mixed with Alphamine Fruit Punch. Last two HV bottles were Paradise Cooler which tasted awesome by itself as well as mixed with my Alphamine.

I'll tough it out but my next bottle of HV will definitely go back to the Paradise Cooler...
Click to expand...

This is why we have raspberry lemonade in High Volume and Alphamine. :)
 
First off, great job on doing your research, many people just jump in without investigating.

Like others, I see no issues....
 
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