High dose forskolin

[Guest]

1) Boosting of thyroid function. Modulation of thyroid-hormone levels via enhancement of T4 synthesis and conversion of T4 (normally synthesized from free tyrosine) to biologically active T3.
2) Potent adaptogen.

Do you have any idea on how much Bacopa is needed to increase conversion? I'm sure you do since you are reccomending it for that purpose.

 

[strategicmove]

Do you have any idea on how much Bacopa is needed to increase conversion? I'm sure you do since you are reccomending it for that purpose.

The precise amount would be hard to pin-down, as it would vary depending on individual metabolic rates. Yet, I would suggest a daily range of 600mg to 900mg of Bacopa Monnieri standardized to 40% Bacosides. This should give between 240mg to 360mg of actives.
The reason, as you know, is that Bacopa boosts thyroxine (T4) synthesis. But because T3 is the metabolically active thyroid component, T4 (about 90% of thyroid hormone) must be converted to T3 (about 10% of thyroid hormone, but up to 10 times more active than T4) to produce required effects. T4-to-T3 conversion is governed by both thyroid-stimulating hormone and growth hormone (GH). Higher GH levels produce low T4 levels, due to greater conversion of T4 to T3. But, thyroid dysfunction can occur if T4 levels drop too low. This is exactly where Bacopa shines, as it continually boosts T4 levels, ensuring stable conversion of T4 to T3. The precisely required amount of Bacopa for T4-to-T3 conversion would, therefore, depend on the amounts of growth hormone and thyroid stimulating hormone available. My conjecture is that a daily dose of about 600mg to 900mg of Bacopa at 40% Bacosides would elicit the required thyroid synthesis.

 

[Guest]

The precise amount would be hard to pin-down, as it would vary depending on individual metabolic rates. Yet, I would suggest a daily range of 600mg to 900mg of Bacopa Monnieri standardized to 40% Bacosides. This should give between 240mg to 360mg of actives.
The reason, as you know, is that Bacopa boosts thyroxine (T4) synthesis. But because T3 is the metabolically active thyroid component, T4 (about 90% of thyroid hormone) must be converted to T3 (about 10% of thyroid hormone, but up to 10 times more active than T4) to produce required effects. T4-to-T3 conversion is governed by both thyroid-stimulating hormone and growth hormone (GH). Higher GH levels produce low T4 levels, due to greater conversion of T4 to T3. But, thyroid dysfunction can occur if T4 levels drop too low. This is exactly where Bacopa shines, as it continually boosts T4 levels, ensuring stable conversion of T4 to T3. The precisely required amount of Bacopa for T4-to-T3 conversion would, therefore, depend on the amounts of growth hormone and thyroid stimulating hormone available. My conjecture is that a daily dose of about 600mg to 900mg of Bacopa at 40% Bacosides would elicit the required thyroid synthesis.

the study was done in rats so we would need about 60grams a day.

 

[strategicmove]

the study was done in rats so we would need about 60grams a day.

The amounts I quoted were my conjectures. I neither quoted any studies nor did I obtain the 600mg to 900mg suggestion from any studies. Yet, even if 60gr equivalents were used in the rat study you seem to have in mind, I speculate that study was done with bacopa as sole compound. Hence, I doubt that the same amount would be required in the presence of GH-boosting compounds.

I apologize I am currently at work and my not be able to respond immediately to any comments you may have. I'll do so, though, whenever I log in again

 

[nelix]

the study was done in rats so we would need about 60grams a day.

Expanding on that.
I dare say rats are not people, which means:
1. The dosage could be much greater or much less
2. The effect may not even cross over to humans

It could go ether way, I would base any opinion on this subject on what people experience... Although honestly I have not heard anything.