Nilaul
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Hello; I'm new to the forums. I've been looking at GW-501516; however its potential deadly side effect has put me off. So I came across Telmisartan.
Telmisartan (Mircadis).- Wikipedia, the free encyclopedia
Apparently its a safe alternative to GW-501516; without the possibility of cancer. Its also not illegal, available at every pharmacy, Its not a steroid. Not yet banned for use in sports. Has anyone used Telmisartan? Anyone can state its effects?
Telmisartan (Mircadis).- Wikipedia, the free encyclopedia
Apparently its a safe alternative to GW-501516; without the possibility of cancer. Its also not illegal, available at every pharmacy, Its not a steroid. Not yet banned for use in sports. Has anyone used Telmisartan? Anyone can state its effects?
Edit: I realised this might be in the wrong section of the forum. SorryMode of action[edit]
Telmisartan is an angiotensin II receptor blocker that shows high affinity for the angiotensin II receptor type 1 (AT1), with a binding affinity 3000 times greater for AT1 than AT2. It has the longest half-life of any ARB (24 hours)[1][4] and the largest volume of distribution among ARBs (500 liters).[5][6]
In addition to blocking the RAs, telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma (PPAR-γ), a central regulator of insulin and glucose metabolism. It is believed that telmisartan’s dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD).[4]
Telmisartan's activity at the PPAR-γ receptor has prompted speculation around its potential as a sport doping agent as an alternative to GW 501516.[7] Telmisartan activates PPARδ receptors in several tissues.[8][9][10][11]