So, I noticed the Wikipedia entry on GW501516 mentions that this compound was abandoned as a research chemical by the mfg because it caused cancer in the animals they were testing it on. Thoughts on this?
I can't post the URLs but its on the Wikipedia entry.
From the references:GW501516 (also known as GW-501,516, GW1516, GSK-516 and on the black market as Endurobol[1]) is a PPARδ receptor agonist that was invented in a collaboration between Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s, was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases, and was abandoned in 2007 because animal testing showed that the drug caused cancer to develop rapidly in several organs.
By 2007, GW501516 had completed two phase II clinical studies and other studies relating to obesity, diabetes, dyslipidemia and cardiovascular disease,[9][10] but GSK abandoned further development of the drug in 2007 for reasons which were not disclosed as the time.[11] It later emerged that the drug was discontinued because animal testing showed that the drug caused cancer to develop rapidly in several organs.[12][13][14]
Despite these promising early results, the further investigation and development of GW501516 was discontinued after observations in animal studies of its association with the rapid induction of cancers in several organs (liver, stomach, tongue, skin, bladder, ovaries, womb and testes
I can't post the URLs but its on the Wikipedia entry.