the first ingredient in our compound we will look at is:
MASS 550
Brassaiopsis glomerulata extract is becoming rapidly popular in the sports supplement industry to boost testosterone and decrease estrogen. More and more companies are starting to use this ingredient to market it as an effective testosterone boosting ingredient. In fact, recent study conducted at the college of pharmacy at the University of Illinois in Chicago isolated specific alkoloids from Brassaiopsis glomerulata that showed highly effective anti aromatase characteristics in a cell based study. This in vitro study showed that one of the alkaloids called dehydrololiolide found in this plant was just as effective as some pharmaceutical aromatase inhibitors.
What consumers need to know is that companies currently marketing brassaiopsis glomerulata extract to boost testosterone have yet to isolate the active alkaloids. That is the reason why companies are using hundreds of mgs per serving to hope that this would make their products effective. Brassaiopsis glomerulata contains two alkaloids that illustrate effective anti aromatase inhibiting characteristics. From the study below, you will notice two highly effective alkaloids, which are dehydroliolide and n-benzoyl-l-phenylalanine methyl ester. Most Brassaiopsis glomerulata extract contains less than 1 percent of these two alkaloids. Yes, that is correct LESS THAN 1% in the brassaiopsis glomerulata extract. Finaflex has taken it to the next level, again. Instead of launching a bogus product with brassaiopsis glomerulata extract and claiming testosterone boosting and anti aromatase activities without knowing if the extract contains the active alkaloids, the chemist at Finaflex spent years figuring out how to isolate and extract the two main active alkaloids, dehydrololiolide and N-benzoyl-L-phenylalanine methyl ester. The material contained in the product is standardized at 10% dehydrololiolide and 20% n-benzoyl-l-phenylalanine methyl ester, which is verified by an independent 3rd party cGMP and DEA registered testing facility.
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Percent control activity (PCA) at 20 μg/mL for compounds 1–13 isolated from Brassaiopsis glomerulata in the noncellular, enzyme-based aromatase bioassay and in SK-BR-3 hormone-independent human breast cancer cells that over express aromatase (DMSO = dimethyl sulfoxide, blank/negative control; AG = aminoglutethimide, positive control in noncellular assay, 50 μM; LET = letrozole, positive control in cell-based assay, 10 nM). Each bar represents the mean and standard error of three replicates, with statistically significant differences indicated in the non-cellular assay by different numbers of stars and in the cell-based assay by different letters (P < 0.0001).
9. Represents n-benzoyl-l-phenylalanine methyl ester 12. Represents dehydrololiolide
This is a HUGE breakthrough for all athletes who want to take their training to the next level. This naturally occurring ingredient found in this plant can help you reduce the circulating androgens in the body that can convert into estrogen. Higher estrogen level means lower testosterone production in the human body. So, thereby reducing the estrogen levels in your body, you can maximize your naturally occurring testosterone levels. The in vitro study of dehydrololiolide and n-benzoyl-l-phenylalanine methyl ester shows that these two alkaloids possess high binding affinity to the aromatase enzymes similar to other pharmaceutical aromatase inhibitors. After years of research on the efficacy and bioavailbility, FINAFLEX has the precise dosage of this breakthrough ingredient that will maximize the preferred results. Extrapolating the efficacy dosage of the in vitro study and due to the isolation of the effective alkaloids, REVOLUTION MASS contains the exact amount of dehydrololiolide and n-benzoyl-l-phenylalanine methyl ester to create the perfect environment to optimize your testosterone levels naturally.
The second ingredient contained in the MASS 550, maslinic acid (standardized to 70%) works synergistically with letrosterone to maximize your body’s potential to simply GROW. Maslinic acid is a naturally occurring triterpenoid found in olive pomace. What’s interesting about this compound is that it was found to have anabolic activities in recent in vivo studies. In this study, maslinic acid was added to the diets of rainbow trout using 5 groups of 180 trout. Each of the 5 groups were introduced to different amounts of maslinic acid into their daily diet. This studied revealed some incredible findings that show the power of this incredible ingredient.
“At the end of the experiment, white-muscle weight and protein-accumulation rate of trout fed with maslinic acid were higher than in control. The total content of DNA, RNA, and protein in trout fed with 25 and 250 mg of maslinic acid kg(-1) were significantly higher than in control. The protein : DNA ratio was also slightly higher than control. In the same groups of trout, fractional (K(S)) and absolute (A(S)) protein-synthesis rates increased to more than 80% over the control values while no differences were found in the fractional protein-degradation rate (K(D)).”
What does this all mean? It means that maslinic acid added to the diet acts as a growth factor by increasing white muscle tissue and increasing protein turnover rates.
White muscle weight of the trout that was fed maslinic acid was significantly higher than the control group in the above study. This is a major breakthrough because fish has more muscle than any other vertebrae, which makes up roughly between 40-60 percent of its total body mass. The results of the above study illustrated “that maslinic acid fed to rainbow trout significantly increases whole-body growth rate. Whole-body weight of the trout fed 250 mg maslinic acid kg−1 for 225 days was 29% higher than control.” Yes, 29% growth!
The above study also demonstrated that maslinic acid increased protein turnover rates. What is protein turnover? If you are a bodybuilder, sprinter, football player, endurance athlete or just a fitness enthusiast, protein turnover is the key to your success. Protein turnover rate is the ratio of protein synthesis vs protein degradation. Simply put, your body is in an anabolic state when you have more protein synthesis versus protein breakdown. Conversely, if you have more breakdown than synthesis your body is in a catabolic state. That being said, the outcome of the above study showed that the group with maslinic acid in their diet increased its protein synthesis rate more than 80% compared to the control group. Just imagine if you could increase your body’s ability to synthesize and utilize the protein that you ingest 80% more effectively?
Furthermore, the chemical structure of maslinic acid is similar to steroid hormones and a proposed mechanism of action in cell signaling similar to that of testosterone. Animal studies have shown that Maslinic Acid has a powerful anabolic effect by increasing whole body growth rate, regulating blood glucose, nitrogen retention, and increasing the synthesis of DNA and protein. In recent years, some researches reveal that Maslinic Acid shows beneficial effects in reducing cerebral damage.
Supplements containing ursolic acid are starting to gain popularity due to recent studies of its effectiveness. However, the oral bioavailability of maslinic acid is far superior compared to other triterpenoids such as ursolic acid. A study investigating the intestinal uptake of Ursolic Acid (from an ethanolic extract of Sambucus chinensis) found that a dose contributing 80mg/kg bodyweight Ursolic Acid had about an 0.6% oral bioavailability based on the compound's AUC. However, in recent study illustrating the bioavailability of maslinic acid, the research showed that after the administration of 50mg/kg Maslinic Acid to rats, Maslinic Acid reached the blood and was detected in plasma at 60min (3.08±0.02μM). This confirms that oral bioavailability of maslinic acid is far superior to that of ursolic acid.
References
1. Balunas MJ, Su B, Riswan S, Fong HH, Brueggemeier RW, Pezzuto JM, Kinghorn AD. Isolation and Characterization of Aromatase Inhibitors from Brassaiopsis glomerulata (Araliaceae). Phytochem Lett. 2009 Feb 19;2(1):29-33.
2. Fernández-Navarro, M., Peragón, J. Maslinic acid as a feed additive to stimulate growth and hepatic protein-turnover rates in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. 2006. C 144, 130–140.
3. Mónica Fernández-Navarro a, Juan Peragón. Maslinic acid added to the diet increases growth and protein-turnover rates in the white muscle of rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology, Part C 147 (2008) 158–167.
4. Liao Q, et al. LC-MS determination and pharmacokinetic studies of ursolic acid in rat plasma after administration of the traditional chinese medicinal preparation Lu-Ying extract. Yakugaku Zasshi. (2005).
5. Qiang Z, et al. Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. JEthnopharmacol. (2011).
6. Lozano-Mena G, Juan ME. Determination of maslinic Acid, a pentacyclic triterpene from olives, in rat plasma by high-performance liquid chromatography. J Agric Food Chem. 2012 Oct 17;60(41):10220-5. doi: 10.1021/jf3023996. Epub 2012 Oct 8.
I know the burger was worth every red cent... I want one now.
but now my freezer is devoid of all things beef. I grew up on a farm and we raised 150 head of cattle so every year we slaughtered 1 or 2. I grew up living on healthy, grass fed beef. Now that's all gone and in the past and I have to eat the beef from Costco or Safeway ..... just not the same. If I can ever afford it I will start buying grass fed organic from one of the local farming co-ops but until then its the red dyed crap from the store ..... and even that's getting expensive. 