LakeMountD
Doctor Science
It seems that there are two camps on whether or not to take single or twice daily injections of LR3 IGF-1. I think people are jumping to conclusions entirely too fast about this and that and they heard this from this guy and read this from another guy. Lets try to take a look at it scientifically and maybe, eventually, some light can get shed on the situation. Here are a few questions we can ask ourselves. We know the half life of LR3 IGF-1 is quite long, there is no disputing that. Although different people will say different numbers about IGF-1, I myself am torn as to what the true half life is as I like to go by scientific studies not gut feeling. I will, however, take blood samples 8 times today after an AM injection of 20mcg LR3 IGF-1 to see how long the effects last of the blood sugar. I am not saying that single or twice daily injections are better, I am just trying to help take a look at what we have on the table here.
1. How quickly does LR3 IGF-1 go systemic? This isn't really known but if it is anything like insulin (which it should be) then it goes systemic rather quickly. This means that injecting immediately PWO isn't going to help all that much considering it is going to be circulating through your entire body pretty quickly and won't have time to bind ONLY to the area you just worked.
2. We know lactosis causes an increase in IGF-1R's, that is proven. However, we don't know for how long. Some people seem to think that it is only for a couple hours, which to me makes no sense, or it could be the inverse and make a lot of sense, here is why.
Possibility 2a)IGF-1R's are greatly upregulated in the worked muscle and last there for several days. The reason that this currently seems like the most logical reason is the way the body produces these growth factors naturally. MGF splicing is greatly upregulated following exercise. It is well know that MGF DOES NOT act through the IGF-1R, this was proven by blocking the IGF-1R in studies using antibodies and determining whether there was still a reaction from the MGF, and there was. After 2-4 days the body begins shifting back towards IGF-1Ea splicing and less towards MGF, this would lead me to believe that the IGF-1R's couldn't have been downregulated too quickly since they need to still be there in larger numbers to complete the repairs/differentiation.
Possibility 2b)This is another way of looking at it as I like to do. Your body MIGHT produce IGF-1R's in greater numbers following a workout in a specific area since IGF-1 levels are lower and MGF levels are higher to take advantage of the smaller amounts of IGF-1 that is circulating, then it begins to slowly kill those off as IGF-1 levels rise back up. However, this does not seem logical since we are continually working our muscles and continually getting an influx of MGF and IGF-1 levels. Even if this were the case IGF-1R levels in the affected area still should be elevated quite high for at least an entire day, making injections on non workout days just fine.
This is why I don't see a reason for injecting only PWO, the simple fact that your body is constantly being worked and therefore always has a high number of IGF-1's in some area to take advantage of.
1. How quickly does LR3 IGF-1 go systemic? This isn't really known but if it is anything like insulin (which it should be) then it goes systemic rather quickly. This means that injecting immediately PWO isn't going to help all that much considering it is going to be circulating through your entire body pretty quickly and won't have time to bind ONLY to the area you just worked.
2. We know lactosis causes an increase in IGF-1R's, that is proven. However, we don't know for how long. Some people seem to think that it is only for a couple hours, which to me makes no sense, or it could be the inverse and make a lot of sense, here is why.
Possibility 2a)IGF-1R's are greatly upregulated in the worked muscle and last there for several days. The reason that this currently seems like the most logical reason is the way the body produces these growth factors naturally. MGF splicing is greatly upregulated following exercise. It is well know that MGF DOES NOT act through the IGF-1R, this was proven by blocking the IGF-1R in studies using antibodies and determining whether there was still a reaction from the MGF, and there was. After 2-4 days the body begins shifting back towards IGF-1Ea splicing and less towards MGF, this would lead me to believe that the IGF-1R's couldn't have been downregulated too quickly since they need to still be there in larger numbers to complete the repairs/differentiation.
Possibility 2b)This is another way of looking at it as I like to do. Your body MIGHT produce IGF-1R's in greater numbers following a workout in a specific area since IGF-1 levels are lower and MGF levels are higher to take advantage of the smaller amounts of IGF-1 that is circulating, then it begins to slowly kill those off as IGF-1 levels rise back up. However, this does not seem logical since we are continually working our muscles and continually getting an influx of MGF and IGF-1 levels. Even if this were the case IGF-1R levels in the affected area still should be elevated quite high for at least an entire day, making injections on non workout days just fine.
This is why I don't see a reason for injecting only PWO, the simple fact that your body is constantly being worked and therefore always has a high number of IGF-1's in some area to take advantage of.
