(I pulled this from another forum)
My biggest issue is that Aromasin destroys estrogen and we know arimidex does not completely destroy it. If you destroy estrogen during a 16+ week cycle the biggest negative side affect is a decrease in bone density.
Why would we knowingly take Aromasin when we know its effective rate on destroying estrogen is 85% and we know that we need estrogen not only to build muscle but counter balance the effects of free test on our emotions, sexual organ functionality and bone density?
Its proven that Arimidex is faster and controls estrogen in a fashion that is more functional in our specific use. Short ester SERM's are what we need during cycles becuase the peaks and valleys are so great and we have no unit of measure as to what our bodies are doing exactly.
Nipples flaring is a sign of high estrogen, but it is not a valid gauge of how high our estrogen truly is. Arimidex is more of a nozzle on the estrogen faucet, where Aromasin ends up being a plug.
I understand we want to do the dosing in moderation, but there is nothing moderate about having high estrogen one day and then taking aromasin which completely kills the estrogen the next day, I see that as a significant shift in hormonal activity that they body cannot be happy with or rebound from easily. After all just was with our Test levels, it took 2 to 4 weeks for the body to get those estrogen levels that high.
Aromasin on cycle is old school, Arimidex is the way to go, we want to control the variances not stop and start them. Any written article about aromasin says that its "suicidal" for estrogen, it also mentions that using it helps increase Testosterone production, so again great for PCT, not great for during cycle, the body is confused enough.
Just my own thought.... I think @12.5 ed or even eod it could easily tank estrogen especially if taking it from the get go. As you said some people don't get the estrogen sides... I think everyone is different.... One thing I found w suicidal AIs is that, for me at least, their better used less often. I notice low E sides at ed or eod unless on a highly aromatizing compound.... Everyone's different, in the end OP is gonna have to find what works for him