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Estradiol quick question

LMuscle

LMuscle

Well-known member
My estradiol on cycle is at 91 (testosterone level at 3122ng/dL), should .50 mg of arimadex twice per week get my e2 down to around 40? I don't want to crash my estradiol, and know arimadex is some powerful stuff.
 
LMuscle said:
My estradiol on cycle is at 91 (testosterone level at 3122ng/dL), should .50 mg of arimadex twice per week get my e2 down to around 40? I don't want to crash my estradiol, and know arimadex is some powerful stuff.
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Test at 3000? What's your cycle??

Everyone is different.
 
I thought Arimidex (A.I.) only worked on the aromatase enzyme - meaning it won't flush out the current E levels, but it will help reduce future E production. You're supposed to take it before E levels go high, though I don't see why it wouldn't help reduce it over time. You need Aromasin (S.I.) to reduce current levels, but that runs the risk of crashing it.
 
DirtyWilly said:
I thought Arimidex (A.I.) only worked on the aromatase enzyme - meaning it won't flush out the current E levels, but it will help reduce future E production. You're supposed to take it before E levels go high, though I don't see why it wouldn't help reduce it over time. You need Aromasin (S.I.) to reduce current levels, but that runs the risk of crashing it.
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I have no idea, I've never heard that. All I have is arimidex. I took .50 last night, didn't feel any different. How long does it take for your body to eliminate excess estradiol in your bloodstream when the aromatase enzyme is reduced?
 
Arimidex will keep estrogen from further binding but won't lower it , exemstane is a suicide AI and will actually lower E levels
 
Aromasin is the best AI there is HANDS DOWN. I actually think formestane is better than arimidex as it too is a S.I so it'll clear circulating estrogen too.
 
Adex is fine. You guys ever look up the half life of estrogen? Wether it reduces estrogen or prevents further estrogen production is kind of a mute point. 13 to 17 half life btw.
 
Both adex and exem are ai's, they bind to aromatase so it cannot interact with testosterone to turn into estrogen. The only difference is exemestane is a suicidal ai meaning this binding to the aromatase enzyme cannot be reversed and the bond will last the entire life of aromatase. Adex is a reversible ai meaning this bind will dissolve over time. This is the main difference in the two, the other being exem is steroidal and adex is non steroidal. Exemestane is preferred in pct because adex has a higher chance of rebound after it is discontinued. On cycle is personal preference, most newer guys might want to go for adex because it is a lot more forgiving as far as crushing estrogen levels go.
 
yates84 said:
Both adex and exem are ai's, they bind to aromatase so it cannot interact with testosterone to turn into estrogen. The only difference is exemestane is a suicidal ai meaning this binding to the aromatase enzyme cannot be reversed and the bond will last the entire life of aromatase. Adex is a reversible ai meaning this bind will dissolve over time. This is the main difference in the two, the other being exem is steroidal and adex is non steroidal. Exemestane is preferred in pct because adex has a higher chance of rebound after it is discontinued. On cycle is personal preference, most newer guys might want to go for adex because it is a lot more forgiving as far as crushing estrogen levels go.
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stane is milder and less chance of crashing estro. dex is usually better for most IMO but both work.

no AI in pct... i sick of saying it... it doesnt help pct and research showing ai to boost test levels is on people WITH testlevels and production, in PCT this is not the case.
also even if some rebound since you are on pct the SERMS will block any gyno issues while your hormones level out.
 
Blergs said:
stane is milder and less chance of crashing estro. dex is usually better for most IMO but both work.

no AI in pct... i sick of saying it... it doesnt help pct and research showing ai to boost test levels is on people WITH testlevels and production, in PCT this is not the case.
also even if some rebound since you are on pct the SERMS will block any gyno issues while your hormones level out.
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I agree no ai in pct but some do not and still decide to use one.
 
Would calcium d-glucarate be a good addition to the arimidex to help eliminate excess estrogen? I'm dosing .50mg Arimidex daily for the past 3 days, and next week I'll start doing .25 eod. Surprisingly I'm not getting morning erections now, but I did when my estradiol was over 90. I just couldn't maintain an erection during sex. I wouldn't think that a small dose of .50mg for 3 days would take my estradiol very low if it's starting out at over 90 would it? BTW, could I get away with dosing .50mg twice per week instead of .25mg eod? Just easier to remember since I'm so busy most of the time.
 
May not be estrogen related bro. Grab some cialis, problem solved ;)
 
Spurfy wrote some pretty convincing posts why exem is beneficial during clomid PCT. Only bummer is his posts are spread over several threads/pm's so Id need to collate them into one.

From memory, the gist of it was that exem would keep SHBG from getting too high, and "deactivate" one of the potentially troublesome clomid isomers (which tends to linger long after dosing finishes, too).
 
Why do you want to us an ai? Are you having side effects on cycle? That t to e ratio is already pretty good. I wouldn't use an ai unless you were having sides on cycle.
 
Cgkone said:
Can you unpack that a little?
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When you look at the available research on ais in men you can see this.

There is an arimidex study in men where they found .5mg Ed and 1mg Ed gave about a 50% suppression to e2. So this is where the 1mg Ed dose for studies has come from. I'm not gonna look up the study ATM but with some Google skills you will find it.

Next there is a study on men given androgel and arimidex at 1mg per day or no arimidex at all. The test doses were graded into different groups. All groups showed next to no e2 on the androgel with arimidex, yet the study in healthy mean showed far less suppression.

So there is a feedback loop where when a man off cycle suppresses estrogen he will make more testosterone and thus reverse some of the suppressing effects. On cycle you are not able to make more testosterone to compensate so the suppression is shown to be greater most likely due to this.

You can find both studies if you look around and read them yourself and make your own conclusions.
 
SweetLou321 said:
When you look at the available research on ais in men you can see this.

There is an arimidex study in men where they found .5mg Ed and 1mg Ed gave about a 50% suppression to e2. So this is where the 1mg Ed dose for studies has come from. I'm not gonna look up the study ATM but with some Google skills you will find it.

Next there is a study on men given androgel and arimidex at 1mg per day or no arimidex at all. The test doses were graded into different groups. All groups showed next to no e2 on the androgel with arimidex, yet the study in healthy mean showed far less suppression.

So there is a feedback loop where when a man off cycle suppresses estrogen he will make more testosterone and thus reverse some of the suppressing effects. On cycle you are not able to make more testosterone to compensate so the suppression is shown to be greater most likely due to this.

You can find both studies if you look around and read them yourself and make your own conclusions.
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Thanks
 
SweetLou321 said:
Why do you want to us an ai? Are you having side effects on cycle? That t to e ratio is already pretty good. I wouldn't use an ai unless you were having sides on cycle.
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I was having a few annoying sides, nothing serious like gyno, just overheating, couldn't maintain erection, water retention, lethargy
 
LMuscle said:
I was having a few annoying sides, nothing serious like gyno, just sexual sides
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The more estrogen on cycle the better. If you can treat your sexual dysfunction via different pathways than an ai that's what I would do for sure.
 
LMuscle said:
I was having a few annoying sides, nothing serious like gyno, just overheating, couldn't maintain erection, water retention, lethargy
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None of the these and clinically linked. The only study I know of that studies high estrogen over 50, showed increased libido lol. Gyno would be the only reason I'd use an ai on cycle anyways. Off cycle there is research to support 20-30 for a few health reasons anyways, NOT sexual.
 
SweetLou321 said:
None of the these and clinically linked. The only study I know of that studies high estrogen over 50, showed increased libido lol. Gyno would be the only reason I'd use an ai on cycle anyways. Off cycle there is research to support 20-30 for a few health reasons anyways, NOT sexual.
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Hmm could be I'm just sensitive to high hormone levels, or maybe it's causing high blood pressure. I'll find out soon
 
LMuscle said:
Hmm could be I'm just sensitive to high hormone levels, or maybe it's causing high blood pressure. I'll find out soon
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High bp gives me mega wood lol! Low bp could take the lead out of your pencil. Any fluctuations in hormones can mess with erectile function. A pde5 inhibitor like cialis is your best bet imo.
 
Area1255x said:
Yeah sometimes it isn't related to either Test or E2, and those are more tied to libido than erectile capacity. DHT on the other hand shows connection to erections and libido, with more emphasis on erection quality.
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Any study related info you can link? I'd love to learn more. If it's easy and you don't mind of course. Thanks.
 
Noticed my blood pressure is up on cycle, 144/89. Could that be because of the higher estradiol? I wonder if that's what is causing my issues
 
LMuscle said:
Noticed my blood pressure is up on cycle, 144/89. Could that be because of the higher estradiol? I wonder if that's what is causing my issues
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High estrogen can definitely indirectly contribute to high bp but I doubt that is causing your ed.
 
LMuscle said:
I'm gonna lay off the proviron for a few days and see if that helps.
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Proviron should be helping your situation, lowering estrogen binding at the receptor and increasing libido. Would be very suprised if that helped.
 
MythicalGains said:
91 is extremely high, I think the range goes to ~40-50. I'm surprised you don't feel like complete **** rn.
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Range goes lower than that, and remember his test is >3000 so 90 e2 isn't that bad, might be a problem when it's time to PCT but shouldn't be a problem now. You might have elevated BUN levels because your body's kidneys don't like proviron (which a lot of people forget has a methyl group and DHT's effects on the adrenal system), which might also explain why you are retaining water and hence the high BP, maybe try a few days without the proviron.
 
uprightrows said:
Range goes lower than that, and remember his test is >3000 so 90 e2 isn't that bad, might be a problem when it's time to PCT but shouldn't be a problem now. You might have elevated BUN levels because your body's kidneys don't like proviron (which a lot of people forget has a methyl group and DHT's effects on the adrenal system), which might also explain why you are retaining water and hence the high BP, maybe try a few days without the proviron.
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I've tried today with no proviron, and so far so good. I was doing well on it for the first couple weeks. I'm gonna lay off the proviron for a few more days and just stick with the test prop.
 
Good call, hope it treats you well.
Btw, if the proviron was lowering your shbg that might explain your sort of high e2 level as well, did you get free test or SHBG tested in your blood draw?
 
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