Unanswered ER-beta Agonists

[GreenMachineX]

Dianabol, from what I’ve read, works through the estrogen receptor beta, at least partially, for its ergogenic effects. And some research points to ecdysterone showing the same thing. This isn’t to argue about whether ecdy is actually Anabolic or not, but what are some other natural ER-beta agonists that are out there? I’ve tried some google searching but apparently my google skills aren’t up to par.

I’m not searching this just for Anabolic effects, but I legitimately feel great on a high dose of ecdy. I naturally have low e2 levels and ecdy does just what I need it to for replacing that, but I can’t run it forever because of the unknowns and the cost.

So, are there any others that anyone knows of? Thanks in advance.

 

[HIT4ME]

You mean like..

Apigenin suppresses cancer cell growth through ERbeta - PubMed

Two flavonoids, genistein and apigenin, have been implicated as chemopreventive agents against prostate and breast cancers. However, the mechanisms behind their respective cancer-protective effects may vary significantly. The goal of this study was to determine whether the antiproliferative...

www.ncbi.nlm.nih.gov

ADULT EXPOSURE TO PHYTOESTROGEN APIGENIN RESULTS IN CHANGES IN ENDOCRINE PARAMETERS BUT FAILS TO ALTER FECUNDITY | Science Inventory | US EPA

cfpub.epa.gov

I think maybe you should search for phytoestrogens.

SAGE Journals: Your gateway to world-class research journals

Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.

journals.sagepub.com

 

[GreenMachineX]

You mean like..

Apigenin suppresses cancer cell growth through ERbeta - PubMed

Two flavonoids, genistein and apigenin, have been implicated as chemopreventive agents against prostate and breast cancers. However, the mechanisms behind their respective cancer-protective effects may vary significantly. The goal of this study was to determine whether the antiproliferative...

www.ncbi.nlm.nih.gov

ADULT EXPOSURE TO PHYTOESTROGEN APIGENIN RESULTS IN CHANGES IN ENDOCRINE PARAMETERS BUT FAILS TO ALTER FECUNDITY | Science Inventory | US EPA

cfpub.epa.gov

I think maybe you should search for phytoestrogens.

SAGE Journals: Your gateway to world-class research journals

Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.

journals.sagepub.com

Yes! Guess I’ll be trying apigenin soon...thanks.

 

[GreenMachineX]

Yes! Guess I’ll be trying apigenin soon...thanks.

Well, actually, just saw that apigenin reduces cortisol which I’m already low on..

 

[HIT4ME]

Well, actually, just saw that apigenin reduces cortisol which I’m already low on..

Apigenin is a very interesting compound - but look at that last study, it lists 9 compounds with some ERb activities.

 

[chem.jr.]

Dianabol, from what I’ve read, works through the estrogen receptor beta, at least partially, for its ergogenic effects. And some research points to ecdysterone showing the same thing. This isn’t to argue about whether ecdy is actually Anabolic or not, but what are some other natural ER-beta agonists that are out there? I’ve tried some google searching but apparently my google skills aren’t up to par.

I’m not searching this just for Anabolic effects, but I legitimately feel great on a high dose of ecdy. I naturally have low e2 levels and ecdy does just what I need it to for replacing that, but I can’t run it forever because of the unknowns and the cost.

So, are there any others that anyone knows of? Thanks in advance.

I love ecdy and dbol and pregnenolone so im guessing the estrogenic effect of pregnenolone is why i like it more than dhea.
And apigenin is awesome. HIT may have issues w his little head but his big head works great.

 

[StatePlan1425]

What about its effect on androgen production? Concerns?

Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer - PubMed

Apigenin is a natural flavone. It has recently been used as a chemopreventive agent. It may also have some beneficial effects to treat prostate cancer by inhibiting androgen production. The objective of the present study was to investigate the effects of apigenin on the steroidogenesis of rat...

www.ncbi.nlm.nih.gov

 

[HIT4ME]

I love ecdy and dbol and pregnenolone so im guessing the estrogenic effect of pregnenolone is why i like it more than dhea.
And apigenin is awesome. HIT may have issues w his little head but his big head works great.

Thanks for the compliment...wait...is that a compliment or an insult?

I guess it is open to interpretation.

 

[HIT4ME]

What about its effect on androgen production? Concerns?

Suppression of rat and human androgen biosynthetic enzymes by apigenin: Possible use for the treatment of prostate cancer - PubMed

Apigenin is a natural flavone. It has recently been used as a chemopreventive agent. It may also have some beneficial effects to treat prostate cancer by inhibiting androgen production. The objective of the present study was to investigate the effects of apigenin on the steroidogenesis of rat...

www.ncbi.nlm.nih.gov

It is interesting and I have not read all the science in that one, but there are also a few studies like this out there:

Effects of Apigenin on Steroidogenesis and Steroidogenic Acute Regulatory Gene Expression in Mouse Leydig Cells

Previous studies reported that the age-related decline in testosterone biosynthesis is associated with a decrease in the steroidogenic acute regulatory (StAR) protein which regulates the rate-limiting step of testosterone biosynthesis. To explore the ...

www.ncbi.nlm.nih.gov

Bottom line is I would not expect too much from parsley ...good or bad. But it is a useful compound with benefits.