I have heard that running epistane with primordial performance's 1-T Tren prevents the 1-T Tren from converting into estrogen directly. My understanding of 1-T Tren is that it is a prohormone that is absorbed through the skin and converted to both testosterone and estrogen, unless epistance is stacked with it and then it will almost all convert to testosterone. That being said, I don't think it will act like a SERM. What else are you running / going to run? It might be a good idea to stack epistane as part of your next cycle in addition to taking nolvadex.