nunes; said:
COQ10 is a must to improve cardio and lowering fatigue:....
CoQ10 is certainly an important compound. In general, though, one should prefer the ubiquinol form to the standard form, ubiquinone. As is well known, the key difference between ubiquinone and ubiquinol is that, for the ubiquinone form of CoQ10 to be properly absorbed and utilized by the body, the body must first reduce it to its active metabolite known as ubiquinol. Although researchers have established that most ubiquinone is naturally reduced to ubiquinol, the optimal approach to CoQ10 supplementation remains to consume it in its ready-to-use ubiquinol form. This form is more bioavailable, appears faster in cells, and maintains a longer half-life at the serum (plasma) level.
In my opinion, the ideal CoQ10 supplement would be a combination of ubiquinol and idebenone.
The recommendation by many researchers is to add Idebenone to a CoQ10 supplementation program to get the very best of both compounds.
As is well known, Idebenone, as an analog of CoQ10, can replace CoQ10 in the process of cellular energy production. Idebenone is also, like CoQ10, a powerful antioxidant. However, Idebenone is more water-soluble than CoQ10 and its cellular distribution and antioxidant structure also differ from those of CoQ10, making idebenone superior to CoQ10 in neutralizing some types of free free radicals, but inferior in fighting other types. In particular, idebnone is more effective than CoQ10 in protecting cells from the free radical damage resulting from reduced (abnormal) blood flow. In fact, some studies indicate idebenone is 30-100 times more effective than vitamin E or vinpocetine as a free radical quencher.
Furthermore, Idebenone protects under hypoxic conditions, a situation where CoQ10 may not be an adequate replacement. In addition, Idebenone (unlike CoQ10) has been shown to increase Nerve Growth Factor and enhance cholinergic activity, thus conferring Idebenone with cognitive enhancement abilities.
To continue, Idebenone is a potent anti-oxidant for protecting the very important mitochondria, by both surpressing free radical activity and protecting the unique mitochondrial DNA (mtDNA). This is unique as mtDNA is only derived from our mother's genes.
Finally, when organs are "harvested" for transplant to another patient, it is often the case that Idebenone is used to protect it from damage.
It must be noted, though, that most of the comparison between Idebenone and CoQ10 employed the standard Ubiquinone form of CoQ10, not Ubiquinol. So, stack ubiquinol and idebenone to break your limits!
