DL-185 Dileucine Peptide - A Better Understanding of the Significance of DL-185

sns8778

sns8778

Board Sponsor
DL-185™ Dileucine Peptide
Research Grade Natural Anabolic Peptide
Backed by Human Clinical Studies ​

This article is to discuss DL-185™ Dileucine Peptide and break it down into simple terms to help make it easy for people to understand – what it is, what it does, and how significant that it is.

DL-185™ is a registered trademark and patented ingredient of Ingenious Ingredients LP, Texas, USA.

Supplements containing DL-185™:
  • DL-185™ is available by itself from Competitive Edge Labs (CEL) as MPC-185. (will be available next week)
  • DL-185™ is available in combination with another natural anabolic peptide that was discovered in using advanced AI technology, PeptiStrong®, in Serious Nutrition Solutions (SNS) Pepti-Bolic.
DL-185™ is a state-of-the-art research grade natural anabolic peptide that has been shown in clinical studies to promote 159% greater activation of muscle protein synthesis (MPS) and to boost lower body strength, total strength, & lower body reps to failure.

DL-185™ Highlights/Supports:
  • Lean muscle & strength gains
  • Enhances muscle repair & recovery
  • Boosts muscle protein synthesis by 159%
  • Anabolic & anti-catabolic properties
  • 60% greater activation of muscle protein synthesis as compared to leucine
  • Dramatically boosts lower body strength, total strength, & lower body reps to failure
  • Supported by multiple human clinical research studies
DL-185™ may be beneficial for:
  • Weight trainers
  • Fitness enthusiasts
  • Performance focused athletes
  • Recovery focused athletes
  • Healthy aging & longevity enthusiasts
  • People concerned with losing muscle & strength
  • Anyone that wants to increase strength, perform better, and recover better
----------------------------------------------------------------------------------------------------------
What is DL-185™?
----------------------------------------------------------------------------------------------------------
DL-185™ is a clinically researched natural anabolic and anti-catabolic peptide composed of two leucine molecules bonded together, creating a unique, patented dipeptide structure.

DL-185™ has been shown in human clinical studies to boost lower body strength, total strength, & lower body reps to failure. It has also been shown to increase muscle protein synthesis better than regular leucine - and not just a ‘little better’ either!

159% Greater Activation of Muscle Protein Synthesis
In a groundbreaking study, subjects who consumed 2,000 mg. of DL-185™, the same dosage found in MPC-185 and Pepti-Bolic, demonstrated a 159% greater activation of muscle protein synthesis compared to baseline and 60% greater than regular leucine.

Anabolic Power that Translates into Real World Strength Gains
Activating muscle protein synthesis is cool, but how does this translate into real world results?

Researchers set out to answer that question in a 10-week resistance training clinical study and the results were incredible! Researchers tested lower body strength, total strength, lower body reps to failure, and total reps to failure. There were three groups tested – one group that took 2,000 mg. of DL-185™, one group that took Leucine, and a third that took a placebo.

The results were outstanding:
  • More Total Strength: Subjects taking DL-185™ significantly increased total max strength by 144% as compared to placebo (DL-185™ 154 lbs. vs Placebo 63 lbs.)
  • More Lower Body Strength: Subjects significantly increased their lower body max strength by 189% compared to placebo (DL-185™ 133 lbs. vs. Placebo 46 lbs.). So, if legs are your lagging body-part or if you have trouble gaining leg strength, DL-185™ may be just what you need!
  • More Reps Than Leucine: Subjects taking DL-185™ significantly increased leg press repetitions to failure by 220% compared to leucine (DL-185™ 16 extra reps vs leucine 5 extra reps).
Can you imagine the potential for growth if you could add 16 extra reps to key mass building exercises?

----------------------------------------------------------------------------------------------------------
Let’s Take a Closer Look at the Research:
----------------------------------------------------------------------------------------------------------
We live in a world where there are so many studies and different levels of studies that sometimes we don’t know what to believe anymore. Luckily, there’s no having to wonder about the validity and significance of the studies on DL-185™.

Study #1:
In a double-blind, randomized, crossover study published in 2021 in the Journal of Applied Physiology, researchers found that DL-185™ is more effective than leucine at stimulating muscle protein synthesis in healthy young males.
  • Study: Dileucine Ingestion Is More Effective than Leucine in Stimulating Muscle Protein Turnover in Young Males: A Double Blind Randomized Controlled Trial (Paulussen, Kevin J.M., et al.)
  • Study Type: Double-blind, randomized, crossover study.
  • Study Objective: To assess the effects of dileucine and leucine ingestion on the modulation of muscle protein synthesis and protein breakdown rates in healthy young adults.
  • Participants: 10 healthy, recreationally active males
  • Results: Dileucine increased muscle protein synthesis by 159% compared to baseline and 60% more than leucine.
The significance of this study is that leucine has long been considered the amino acid trigger for increased muscle protein synthesis (MPS), so for Dileucine to increase MPS 60% more than leucine is phenomenal and supported the idea that Dileucine may have incredible potential for supporting lean muscle, strength, improved performance, & enhanced recovery.

Study #2:
A randomized double-blind placebo controlled study that was originally presented at the 2023 International Society of Sports Nutrition (ISSN) conference was recently published in the prestigious journal PLOS One. This may not mean anything to the average person who is not familiar with these terms, but to anyone that is, they know how significant that this is.

PLOS One is a peer-reviewed open access scientific journal that prioritizes research with strong methodology and high ethical standards, not just groundbreaking findings and all articles undergo a thorough peer review process.

This study validates earlier findings that demonstrated DL-185™ has superior effects compared to leucine for increased muscle protein synthesis (MPS) and adds to the growing evidence showing DL-185’s role in supporting muscle, strength, and performance.
  • Study: Dileucine ingestion, but not leucine, increases lower body strength and performance following resistance training: A double-blind, randomized, placebo-controlled trial (Hagle, et. al 24)
  • Study Type: Randomized, double-blind placebo control human trial.
  • Study Objective: Examine Dileucine’s effects on resistance training adaptations
  • Study Duration: 10 weeks
  • Study Participants: 32 resistance-trained males
Study Design:
The researchers employed a robust 10 week design that divided the participants into three groups:
  • Dileucine group: 2 grams DL-185 dileucine
  • Leucine group: 2 grams leucine
  • Placebo group: 2 grams resistant starch
This three-way comparison model allowed researchers to determine not only if Dileucine was effective, but also how it compared to traditional leucine supplementation.

The double-blind nature of the study means that neither the participants nor the researchers knew which supplement they were receiving, thereby eliminating any potential bias.

Participant Characteristics:
This study consisted of 32 resistance trained males with the following characteristics:
  • Average age: 28 years old (+/- range 6 years)
  • Average height: approximately 5’8 to 5’10 (+/- range of 2.9 inches)
  • Average weight: 175.7 lbs. (+/- range of 27.6 lbs.)
  • Average body mass index (BMI): 25.7 (+/- 3.9 kg/ m²)
  • Average body fat percentage: 19% (+/- range of 5.7%)
  • Minimum training experience: All participants had at least 1 year of prior resistance training experience. This was verified by the requirement of participants to meet specific strength training markers.
  • Participants were required to discontinue all ergogenic nutritional supplements except for multi-vitamins/minerals for at least 30 days before and after the study and during the study.
  • Participant candidates that reported using any anabolic-androgenic steroids within the prior 12 months were excluded from the study.
This is all very significant because this criteria was designed to reflect the most accurate comparison to the average weight training & fitness minded supplement user.

Training Regimen:
The training program was rigorously designed to ensure consistency across all three groups.
  • 4 training sessions per week
  • Split body routine targeting all major muscle groups
  • 3-4 sets per exercise
  • 6-10 reps per set
  • 70%-85% of one-rep maximum intensity range
This protocol was followed for the entire 10 week period and researchers monitored participant compliance.

Key Strength-Related Findings:
The study demonstrated several significant outcomes:
  • Leg Press Strength: The dileucine group showed significantly greater increases in leg press one rep max compared to placebo. The difference was dramatic, with a 95% confidence interval of 5.8 to 73.2 kg. improvements.
  • Muscular Endurance: The dileucine group showed greater improvements in leg press repetitions to failure compared to the leucine group. The endurance improvements ranged from 0.58 to 20.3 additional reps.
  • Total Strength: The dileucine group showed greater increases in total strength (leg press + bench press) compared to placebo. The improvements showed a 95% confidence interval of 6.8 to 75.9 kg.
This double-blind randomized placebo controlled study demonstrated both the effectiveness of DL-185™ and that it outperforms traditional leucine supplementation. This is significant because leucine has long been considered the gold standard for amino acid muscle protein synthesis activation!

----------------------------------------------------------------------------------------------------------
The Significance of Outperforming Leucine
----------------------------------------------------------------------------------------------------------
Muscle protein is in a constant process of being continuously broken down and resynthesized. Muscle building takes place when the rate of muscle protein synthesis exceeds the rate of muscle protein breakdown. One specific amino acid - L-Leucine is the most powerful and has long been regarded as an anabolic trigger – turning on muscle protein synthesis.

Muscle protein synthesis (MPS) is the process by which your body uses amino acids to build new muscle protein, essentially meaning it’s how your muscles grow and repair themselves after exercise by creating new muscle tissue from the protein you consume.

Muscle protein synthesis is crucial for muscle growth, recovery, and overall muscle heath. It’s basically the body’s way of repairing and growing muscle tissue, making it a key factor in building muscle mass.
Physical activity, especially resistance training, triggers muscle protein synthesis by creating microscopic tears in muscle fibers that need to be repaired.

Triggering muscle protein synthesis helps to repair and rebuild the muscle fingers that you broke down during exercise. This rebuilding process is what leads to muscle growth (hypertrophy). In order to make this process as efficient as possible, you need to ensure you’re consuming adequate protein (the building blocks of muscles), and it’s essential to stimulate muscle protein synthesis (MPS is a process, not a protein).

Leucine has been shown in clinical research to be a key regulator in the pathways of muscle protein synthesis, playing a crucial role in activating muscle anabolism, and without its presence, this activation doesn’t happen. Therefore, the faster leucine gets absorbed and delivered into the muscles, the faster it can activate muscle protein synthesis and turn on this key pathway of growth and recovery.

This is why leucine is considered the amino acid gold standard as a baseline comparison for how well other ingredients activate muscle protein synthesis, and why when researching supplement ingredients, comparing their muscle protein synthesis activation to leucine is a common baseline for analysis.

Misconceptions & What This Means:
There are a lot of misconceptions about Leucine’s role in muscle protein synthesis and what this all means and about its limitations.

A lot of people, if they read a study where something is being compared to leucine for muscle protein synthesis activation, they mistakenly think that it means to take more leucine or that the ingredient being studied is being compared directly to leucine – that is NOT the case!

Leucine is the gold standard for amino acid muscle protein activation – the study is comparing the amount of activation on muscle protein synthesis – leucine is being used as the baseline comparative standard.

There is a big difference between total leucine intake and the amount of leucine that activates muscle protein synthesis (MPS), and the key difference lies in how your body processes it and the threshold needed to initiate or trigger MPS.

What is leucine’s role in muscle protein synthesis?
Leucine is a branched chain amino acid and essential amino acid that acts as a ‘trigger’ for muscle protein synthesis (MPS).

What does this mean?
When you consume leucine, it gets absorbed into your bloodstream, and it plays a key role in activating the mTOR (mechanistic target of rapamycin) pathway, which is essential for MPS. This activation is what kicks off the muscle repair and muscle growth process.

Wouldn’t it be better to just take more leucine?
No. There is a threshold of leucine needed to activate this pathway effectively (2-3 grams). Once that threshold is reached, taking more leucine doesn’t produce a significantly greater effect on MPS.

This is where a lot of people get confused because they think – well, why not just take more leucine? Because taking more leucine isn’t going to activate any additional muscle protein synthesis – which is why we look for things that are more powerful than leucine for activating MPS.

In Summary:
  • Leucine activates muscle protein synthesis (MPS) by triggering the mTOR pathway, but there is a threshold (around 2-3 grams at once) after which additional leucine does not provide more benefit for increasing MPS.
  • Total leucine intake over the day matters, but more leucine in one meal does not mean better muscle growth. In simple terms, you can’t rely on eating a lot of protein or taking a scoop of leucine per day to increase MPS.
  • So, the difference between activating MPS and just taking more leucine is that after a certain point, your body isn’t going to trigger more muscle growth from leucine alone.
Therefore, if something increases muscle protein synthesis (MPS) more effectively than leucine, simply taking more leucine won’t produce the same effect. Here’s why:
  • Leucine Activation of mTOR: As mentioned, leucine activates muscle protein synthesis by stimulating the mTOR pathway. However, there’s a threshold beyond which additional leucine doesn’t provide a significantly greater boost to mTOR activation or MPS. The body has a limit to how much Leucine it can use in one go for this purpose.
  • Other Factors at Play: If a different compound or nutrient is more effective at stimulating MPS, it may work through a different mechanism or pathway that complements or augments what leucine does. For example, certain peptides, hormones, or other amino acids might activate the mTOR pathway more robustly or could promote MPS through different signaling mechanisms that leucine alone doesn’t trigger as effectively.
  • Leucine Saturation: Once leucine reaches a certain threshold and mTOR is maximally activated, additional leucine doesn’t have a greater effect. But another compound that stimulates MPS more effectively might continue to boost the rate of muscle growth or enhance recovery, even if you’re already getting the maximal effect from leucine.
  • Synergy with Other Nutrients: Many other compounds or amino acids might work in synergy with leucine, improving MPS through complementary mechanisms. For example, there are some ingredients/nutrients that can also enhance MPS in ways that leucine alone can’t replicate.
In short, while leucine is a powerful activator of muscle protein synthesis, there are other compounds that might enhance MPS more efficiently or in different ways. You can’t just take more leucine to replicate those effects because they operate through different mechanisms, and your body’s response isn’t just about the amount of leucine—it’s about how well the body responds to various signals for muscle growth.

Remember – Muscle Protein Synthesis is a PROCESS!

So, when something outperforms the gold standard for comparative analysis by 60%, that’s a big deal!

----------------------------------------------------------------------------------------------------------

If you are interested in boosting your muscle protein synthesis by 159% and increasing lower body strength, total strength, reps and accelerating muscle repair and recovery, DL-185™ is available in:

MPC-185 – https://competitiveedgelabs.com/product/mpc-185-dl-185-dileucine-peptide/
Pepti-Bolic - https://seriousnutritionsolutions.com/product/pepti-bolic/
 
Last edited:
Why is lower body strength increased more on certain compounds? The ripfactor study had mentioned better lower body strength as well and it is true. Just curious if anyone knows why? Looking forward to adding this in. This seems like a great longterm supplement. While I've not yet used peptristrong, it looks like the perfect addition. I have some peptiplex that I've not yet tried, but when I do, I will stack it with this. Good stuff, Steve.
 
This is a very exciting, interesting ingredient. A couple questions:
1) this stimulates MPS better than Leucine so would it make sense to have BCAA with this or would it not add anything else?
2) would it be beneficial to have BCAA at other times throughout the day still?
 
Halfnattyman44 said:
This is a very exciting, interesting ingredient. A couple questions:
1) this stimulates MPS better than Leucine so would it make sense to have BCAA with this or would it not add anything else?
2) would it be beneficial to have BCAA at other times throughout the day still?
Click to expand...

I had posted another thread last night on muscle protein synthesis and it goes into more detail about muscle protein synthesis and what comparing muscle protein synthesis activation to leucine means.

Link: https://anabolicminds.com/community...is-made-simple-a-better-understanding.339174/

To answer your questions:
1) this stimulates MPS better than Leucine so would it make sense to have BCAA with this or would it not add anything else?

^^^ You could still have your BCAA/EAA's with this because they may still help you; and even if not, then in theory DL-185 would be helping you utilize them better for muscle growth anyway. (I could go into a super science answer to do pro's and con's, but it would be confusing and I think ultimately still wind up back at the simple answer).

I personally don't plan to take less EAA's before and during training; I feel that they have benefits and that DL-185 may can help increase those benefits.

For people that don't use BCAA's/EAA's before and during training, I think that DL-185 is great option to help them increase MPS.

2) would it be beneficial to have BCAA at other times throughout the day still?

Adding DL-185 would be no reason to stop consuming BCAA/EAA's throughout the day if you do that and it works well for you.
 
Jeremy1 said:
Why is lower body strength increased more on certain compounds? The ripfactor study had mentioned better lower body strength as well and it is true. Just curious if anyone knows why? Looking forward to adding this in. This seems like a great longterm supplement. While I've not yet used peptristrong, it looks like the perfect addition. I have some peptiplex that I've not yet tried, but when I do, I will stack it with this. Good stuff, Steve.
Click to expand...

This is just a guess because I've never looked into that very in depth - but my guess would be that lower body strength is much easier to quantify increases in in general and especially across multiple test subjects.

PeptiStrong and DL-185 go great together.

Pepti-Bolic is a great product for people that want them both together and just them.

MPC-185 & Pepti-Plex will go great together for people that want all of the other endurance, senolytic, blood flow, and healthy aging & longevity benefits that Pepti-Plex has to offer.
 
sns8778 said:
Wouldn’t it be better to just take more leucine?
No. There is a threshold of leucine needed to activate this pathway effectively (2-3 grams). Once that threshold is reached, taking more leucine doesn’t produce a significantly greater effect on MPS.

This is where a lot of people get confused because they think – well, why not just take more leucine? Because taking more leucine isn’t going to activate any additional muscle protein synthesis – which is why we look for things that are more powerful than leucine for activating MPS.
Click to expand...

Thank you for explaining this. I had been specifically wondering this myself
 
Jeremy1 said:
Why is lower body strength increased more on certain compounds? .
Click to expand...
Pretty sure this was the case for the Betaine Anhydrous studies as well.

Not to derail this thread. Dl-185 is very exciting.
 
This is odd to me that something would target a certain region of the body more than another. The only thing that would come to mind is some sort of an effect with increased androgen sensitivity similar to how exogenous test increases the size of shoulders, chest, and traps due to the number of receptors in that area. I certainly think that if there was more information on it, it would be an incredible breakthrough.
 
kisaj said:
This is odd to me that something would target a certain region of the body more than another. The only thing that would come to mind is some sort of an effect with increased androgen sensitivity similar to how exogenous test increases the size of shoulders, chest, and traps due to the number of receptors in that area. I certainly think that if there was more information on it, it would be an incredible breakthrough.
Click to expand...

I think its just a common testing parameter.

If you want to gauge improvements across a broad group, lower body strength is a good gauge.

Smaller muscle groups are much harder to gauge consistently.

I think that most things that help lower body strength are going to help total strength in other places too.
 
sns8778 said:
I think its just a common testing parameter.

If you want to gauge improvements across a broad group, lower body strength is a good gauge.

Smaller muscle groups are much harder to gauge consistently.

I think that most things that help lower body strength are going to help total strength in other places too.
Click to expand...
How many times a day can you take it to get optimal mps
 
Firefly 66 said:
How many times a day can you take it to get optimal mps
Click to expand...

The maximum study dosage has been 2 grams per day.

I think that a person can do 2 grams once per day or 1 gram twice per day for the 2 grams total.

I don't see any reason why a person couldn't use more than 2 grams per day if they wanted to, I think that would just come down to cost. I am thinking of doing that myself with MPC-185 & Pepti-Bolic when I get back to training properly. I normally train at night and sometimes do cardio in the mornings, so I was thinking of doing 3 caps Pepti-Bolic w/ 2 caps of MPC-185 in the morning and again at night.

I had also thought about experimenting with an idea on myself of stacking Pepti-Bolic and MPC-185 and taking half dose of each twice per day spaced out from one another - basically that would be 1 gram DL-185 approximately every 4 hours. I would do this when I do my quick cut to help retain muscle. I would be getting in additional PeptiStrong also from Pepti-Plex, which I use as part of my daily supplement regimen bc it helps me tremendously with the muscle damage in my leg from an accident.
 
I had the chance to buy this early and have been running it for the past two weeks.

I did my leg routine last week which consists of two separate days. Usually 1-2 days in between. This time it was 2 and by the time I did the second session it felt like day 1 never happened. Both were great sessions with perfect mind and muscle connection.

This ingredient is legit and could easily become a staple. It's awesome Steve has been able to bring it to us and not at the Muscletech price.

Thx again @sns8778 for putting this together.
 
MPC-185 (front).webp
MPC-185 (SUPP FACTS).webp



MPC-185 Intro & Discussion Thread (and intro sale)
Link: https://anabolicminds.com/community...ucine-peptide-intro-discussion-thread.339229/
 
sns8778 said:
I had posted another thread last night on muscle protein synthesis and it goes into more detail about muscle protein synthesis and what comparing muscle protein synthesis activation to leucine means.

Link: https://anabolicminds.com/community...is-made-simple-a-better-understanding.339174/

To answer your questions:
1) this stimulates MPS better than Leucine so would it make sense to have BCAA with this or would it not add anything else?

^^^ You could still have your BCAA/EAA's with this because they may still help you; and even if not, then in theory DL-185 would be helping you utilize them better for muscle growth anyway. (I could go into a super science answer to do pro's and con's, but it would be confusing and I think ultimately still wind up back at the simple answer).

I personally don't plan to take less EAA's before and during training; I feel that they have benefits and that DL-185 may can help increase those benefits.

For people that don't use BCAA's/EAA's before and during training, I think that DL-185 is great option to help them increase MPS.

2) would it be beneficial to have BCAA at other times throughout the day still?

Adding DL-185 would be no reason to stop consuming BCAA/EAA's throughout the day if you do that and it works well for you.
Click to expand...

Hey 👍

Is it actually possible to increase Muscle Protein Synthesis more than say what 3g of Leucine would achieve? I thought 2-3g of leucine spiked MPS to it's maximum? I personally use EAA's after a workout. It has 3g of Leucine per serving. Do you think adding this can raise it higher or longer?

Wouldn't you also need a protein source alongside this? Leucine without all the other amino acids = no growth?

Just wondered the benefits over and above a 3g leucine based EAA supplement.

Thanks
 
bell1986 said:
Hey 👍

Is it actually possible to increase Muscle Protein Synthesis more than say what 3g of Leucine would achieve? I thought 2-3g of leucine spiked MPS to it's maximum? I personally use EAA's after a workout. It has 3g of Leucine per serving. Do you think adding this can raise it higher or longer?

Wouldn't you also need a protein source alongside this? Leucine without all the other amino acids = no growth?

Just wondered the benefits over and above a 3g leucine based EAA supplement.

Thanks
Click to expand...

All that info is here.

Great write up Steve!
 
bell1986 said:
Hey 👍

Is it actually possible to increase Muscle Protein Synthesis more than say what 3g of Leucine would achieve? I thought 2-3g of leucine spiked MPS to it's maximum? I personally use EAA's after a workout. It has 3g of Leucine per serving. Do you think adding this can raise it higher or longer?

Wouldn't you also need a protein source alongside this? Leucine without all the other amino acids = no growth?

Just wondered the benefits over and above a 3g leucine based EAA supplement.

Thanks
Click to expand...

I'm going to break the reply down in parts in order to reply to the individual parts of your post. I'll put your questions in italics and red to make it easier for myself and anyone reading to distinguish.

I may be a bit confused, bc the answers to some of the questions you asked seem to be in the quote that you quoted to ask the questions - I don't mean that in a bad way, I mean that you may be asking a question differently than how I'm taking it, so if that's the case, just let me know and I'll be glad to answer.

A lot of what you asked about is discussed in great detail in the write up - I tried to be very detailed in order to address those things, but I also realize when a write up is that long, its easy to zone out reading it or to miss things in it.

Is it actually possible to increase Muscle Protein Synthesis more than say what 3g of Leucine would achieve?

The universally recognized dosages for Leucine and MPS activation are 2 to 3 grams, with 2 grams being the most common because its been the dose that seems to be the most widely studied and shown to bee effective across different types of people for increasing muscle protein synthesis. (That doesn't mean not to take more leucine, we're talking muscle protein synthesis, not total leucine intake for other purposes).

Study #2 listed above shows that DL-185 was shown to increase muscle protein synthesis by 159% and 60% more than leucine and also there were some very impressive strength gains with the DL-185 group.

Copy and pasted from above for convenience:

Key Strength-Related Findings:
The study demonstrated several significant outcomes:
  • Leg Press Strength: The dileucine group showed significantly greater increases in leg press one rep max compared to placebo. The difference was dramatic, with a 95% confidence interval of 5.8 to 73.2 kg. improvements.
  • Muscular Endurance: The dileucine group showed greater improvements in leg press repetitions to failure compared to the leucine group. The endurance improvements ranged from 0.58 to 20.3 additional reps.
  • Total Strength: The dileucine group showed greater increases in total strength (leg press + bench press) compared to placebo. The improvements showed a 95% confidence interval of 6.8 to 75.9 kg.
This double-blind randomized placebo controlled study demonstrated both the effectiveness of DL-185™ and that it outperforms traditional leucine supplementation. This is significant because leucine has long been considered the gold standard for amino acid muscle protein synthesis activation!

I thought 2-3g of leucine spiked MPS to it's maximum?
No, that doesn't mean that something can't increase muscle protein synthesis more than leucine.

It means that that is the maximum amount that leucine can increase MPS, in that taking additional leucine will not increase MPS any more than 2-3 grams will.

Copy and pasted from above for convenience:

Wouldn’t it be better to just take more leucine?
No. There is a threshold of leucine needed to activate this pathway effectively (2-3 grams). Once that threshold is reached, taking more leucine doesn’t produce a significantly greater effect on MPS.

This is where a lot of people get confused because they think – well, why not just take more leucine? Because taking more leucine isn’t going to activate any additional muscle protein synthesis – which is why we look for things that are more powerful than leucine for activating MPS.


Do you think adding this can raise it higher or longer?

The 32 person double-blind, randomized, placebo controlled study proved that it can.

It showed that DL-185 increased MPS 159% against baseline and 60% more than leucine, and also showed some really good comparisons in strength gains.

Not going to copy and paste that part again since it would be repetitive with what I already copied and pasted into this post.

Wouldn't you also need a protein source alongside this?

I included a question about protein intake in the thread I posted yesterday for the MPC-185 product under thee FAQ section. Read over this when you have time as this write up covers most of what's above in this thread and also adds to it - https://anabolicminds.com/community...ucine-peptide-intro-discussion-thread.339229/

Copy and paste from that thread:

Do I need to consume adequate protein if I take MPC-185?
It is important to consume adequate protein intake in order to get the best possible results from your training regimen.

The role of MPC-185 is to increase muscle protein synthesis – which is the process by which your muscles repair themselves & grow!

Remember that there is a big difference between total protein intake and triggering muscle protein synthesis!

Leucine without all the other amino acids = no growth?
That's not necessarily true because the subject is very complex in general - but when discussing leucine's effect on muscle protein synthesis, we're discussing it activating a growth process.

But the extent of leucine's comparison to DL-185 is the study comparing them head to head in which DL-185 was shown much more effective.

DL-185 is a dipeptide composed of two leucine molecules bonded together, creating a unique, patented dipeptide structure.

Just wondered the benefits over and above a 3g leucine based EAA supplement.

DL-185 has been shown to be more effective than 2g of leucine in the study, but that doesn't mean not to take leucine or eaa's. It's important to understand that most scientific studies need a control point - and the studies used leucine since its the amino acid gold standard for MPS.

Just because something outperforms leucine doesn't mean not to take leucine.

Think about it like this - just because leucine increases MPS more than the other EAA's, that doesn't mean not to take the other EAA's; or just bc Pantesin may lower cholesterol more than Citrus Bergamot, that doesn't mean not to use both. I hope that makes sense.

Muscle protein synthesis needs to be triggered multiple times per day for maximum muscle growth and recovery. In your case, if using leucine/eaa's post training, I would likely use DL-185/MPC-185 at a different time of the day and would use it daily, not just on training days.


Check out the other thread I linked to because it does have a few more things added to it.
 
You must log in or register to reply here.
Back
Top