Haven't used dermacrine myself, but it would make a decent base. Wouldn't be a bad idea to add something like Epiandro at least PWO though. Gives nice aggression in the gym, keeps libido up as a DHT derivative , etc.....
As you'll hear a lot of people say "Test is best" so if you aren't down with pinning test, you can probably find Test TD if you know where to look, or just go with 4-andro that'll convert to test.
I'll tell ya though, even while pinning test I got some pretty bad lethargy from Dien and I was using the TD version as well. Everyone is different of course.
Also - I will fully admit I'm still learning a lot of these things, so some others with Dermacrine experience might chime in, but ultimately I *believe* it's primarily DHEA which is the mother of all hormones and progesterone which is the grandmother of all hormones so they say. Point is, they'll help to convert into whatever hormone your body is in need of from what I understand.