If its a td then in this case I wouldnt be concerned. Id still probably opt for twice daily application depending on dose/quantity, but once would likely be sufficient.
The thing with td is that its kinda like dripfeeding the active into the bloodstream; great for compounds with very quick eliminations and/or crappy oral bioavailability. So, within certain ranges, the halflife is kinda irrelevant (we're not talking about an undecanoate ester, for example).
With td, youll tend to miss out on the plasma peak seen with other admin routes (oral/IM) but youll get much more sustained plasma levels over time (lower peak, higher trough).
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