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DermaTrest Timing

hrdgain81

hrdgain81

Member
Reposting this in the anabolics section instead of OL UK forum. The bottle says to dose after shower, and pre-workout. I workout first thing in the morning, so dosing pre-workout, then showering immediately after for work seems counter productive.

Also, I believe I read dosing 12 hours apart is optimal due to the transdermal absorption taking place slowly, however dosing before bed is already giving me night sweats and made it a little tougher to fall asleep. Any advice on how to time dosing would be greatly appreciated.
 
hrdgain81 said:
Reposting this in the anabolics section instead of OL UK forum. The bottle says to dose after shower, and pre-workout. I workout first thing in the morning, so dosing pre-workout, then showering immediately after for work seems counter productive.

Also, I believe I read dosing 12 hours apart is optimal due to the transdermal absorption taking place slowly, however dosing before bed is already giving me night sweats and made it a little tougher to fall asleep. Any advice on how to time dosing would be greatly appreciated.
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You could just start showering at night before sleep instead. If that'll work for you. You could change the dosing so that you are applying less before bed and more pre-workout. Or just over-all lower your dosage. Trest is some strong stuff. You really don't need much for a great cycle. Even 50mg total is good.
 
Thanks T-bone, this is my first go with Trest and to say I'm excited is an understatement.

What I did today was gym, shower, apply 1ml so that's about 25mg at 9am. I'll shower again tonight and apply another 1ml around 9pm, if I have issues sleeping I'll dose more in the am and less in the pm like you suggested and see how it goes.

Since you're a big fan, have you noticed any significant effects dosing pre-workout?

Also full disclosure I'm stacking with LGD for 10 weeks, first 3 weeks also stacked with osta (left over from another cycle).
 
hrdgain81 said:
Thanks T-bone, this is my first go with Trest and to say I'm excited is an understatement.

What I did today was gym, shower, apply 1ml so that's about 25mg at 9am. I'll shower again tonight and apply another 1ml around 9pm, if I have issues sleeping I'll dose more in the am and less in the pm like you suggested and see how it goes.

Since you're a big fan, have you noticed any significant effects dosing pre-workout?

Also full disclosure I'm stacking with LGD for 10 weeks, first 3 weeks also stacked with osta (left over from another cycle).
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I always stacked it with the oral version pre-workout so I can't say if I'd notice something pre-workout with the dermal version only. Plus I've never used LGD, so I know nothing about that.
 
T-Bone said:
I always stacked it with the oral version pre-workout so I can't say if I'd notice something pre-workout with the dermal version only. Plus I've never used LGD, so I know nothing about that.
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Have you dosed oral higher than 50mg prewo? Dosing 50mg at mo, pre, if i add more dunno if i should add it to prewo dose or spread it. Only 4 days in.
 
NewAgeMayan said:
Have you dosed oral higher than 50mg prewo? Dosing 50mg at mo, pre, if i add more dunno if i should add it to prewo dose or spread it. Only 4 days in.
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I took two pre-workout and took a bunch with me in a little pill carry case thing. The boost doesn't last long and trest doesn't stay in your system long at all. I read 40 minutes and that was with IV versions. Saw this information posted over at PHF, by mr.cooper69. It's almost not even worth it to take it pre-workout. Next time I have some of the oral version I'm not even gonna bother taking it pre-workout. Unless you could in the locker room 5 minutes before warm up. Then take two after warm up. Empty the caps in your mouth, it's better that way. Repeat every 20 minutes. Well within reason....Just use your head. If your still amped up, obviously you want to hold off a bit.

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So this is what I read on that study:

" In normal men, a single intravenous bolus of 500 micrograms of MENT led to peak serum MENT levels at 3 minutes after dosing (when the first samples were collected), followed by an exponential decline, reaching undetectable levels by 180 minutes. The average terminal half-life and the metabolic clearance rate (MCR) were calculated to be 40 minutes and 2,360 L/day, respectively. The results of the pharmacokinetic studies show that in both men and monkeys, the MCR of MENT is much faster than the values reported for testosterone. The faster MCR can be attributed, in part, to the finding that, in contrast to testosterone, MENT showed no binding to sex hormone binding globulin (SHBG)."

First off the IV doss was a mere 500mcg. Yes it was IV but that's a tiny dose. Also I assume the quicker you get it in your system the quicker it peeks and drops off hence why IV is so fast.

So if someone took 25mg orally that's 50 x the 500mcg dose.

Do we have any info on peak serum levels via oral as well as half life info of oral?
 
DieselNY said:
So this is what I read on that study:

" In normal men, a single intravenous bolus of 500 micrograms of MENT led to peak serum MENT levels at 3 minutes after dosing (when the first samples were collected), followed by an exponential decline, reaching undetectable levels by 180 minutes. The average terminal half-life and the metabolic clearance rate (MCR) were calculated to be 40 minutes and 2,360 L/day, respectively. The results of the pharmacokinetic studies show that in both men and monkeys, the MCR of MENT is much faster than the values reported for testosterone. The faster MCR can be attributed, in part, to the finding that, in contrast to testosterone, MENT showed no binding to sex hormone binding globulin (SHBG)."

First off the IV doss was a mere 500mcg. Yes it was IV but that's a tiny dose. Also I assume the quicker you get it in your system the quicker it peeks and drops off hence why IV is so fast.

So if someone took 25mg orally that's 50 x the 500mcg dose.

Do we have any info on peak serum levels via oral as well as half life info of oral?
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Damnit I fked up shouldn't have brought oral trest
 
zman86 said:
Damnit I fked up shouldn't have brought oral trest
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Dont despair!

Im 5 days in, dosing prewo. First 4 days 50mg, meh. Today 75mg, still no acute effects but I will tentatively say my lethargy (week 6 of lgd) is lifting.

Im gonna try a few more bolus prewo doses then switch to 1cap every few hrs. Will post updates here.
 
zman86 said:
Damnit I fked up shouldn't have brought oral trest
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Lol you are full of regret huh? Just take it and see for yourself, you might like it. And placebo is actually very strong, just think you will peak like crazy within the hour and you might just break some prs. The mind is a powerful thing ;)
 
I have dermatrest and was planning do 2 times a day on my body then the oral caps before a workout like in the locker room.
 
NewAgeMayan said:
Dont despair!

Im 5 days in, dosing prewo. First 4 days 50mg, meh. Today 75mg, still no acute effects but I will tentatively say my lethargy (week 6 of lgd) is lifting.

Im gonna try a few more bolus prewo doses then switch to 1cap every few hrs. Will post updates here.
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What dose are you running the LGD at? I'm on day 3 @4mg and the lethargy is a little rough. What have you seen over 6 weeks?
 
hrdgain81 said:
What dose are you running the LGD at? I'm on day 3 @4mg and the lethargy is a little rough. What have you seen over 6 weeks?
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First 4wks at 4mg, then increased to 6mg. Strength gains most noticeable around second to third week, but they have dropped off. Been some lean mass gains, not alot, but more than I wouldve got previously. Lethargy became quite bad at week 4-5, no libido loss though.
 
Thanks NewAgeMayan, I'm debating whether I should up the DermaTrest dosage from 50 to 75mg to combat the lethargy, but I'll give it a week or so before I make that determination.
 
hrdgain81 said:
Thanks NewAgeMayan, I'm debating whether I should up the DermaTrest dosage from 50 to 75mg to combat the lethargy, but I'll give it a week or so before I make that determination.
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Well as I said previously, it seems as if my lethargy is starting to lift, but whether this is due to increasing my Tr3st dose from 50 to 75mg or just being on it for 5 days I cant say with any certainty. Id maybe give things a bit longer?
 
NewAgeMayan, maybe the trest is just cancelling out some of the lethargy from your LGD. That could be why you aren't really feeling much from it. When I took the oral trest I seriously took a lot more than people normally take and didn't only take it pre-workout. Maybe 2-3 pre-workout and took another bunch to the gym in a pill container/carrier. I dumped something like 7 or 8 in the container and took a few maybe every 15 minutes during my workout. Didn't always take the same amount of caps, just depended on how long my workout lasted. Also emptying the caps in your mouth works better than just taking the caps.

That's how I used anyway and it works/worked amazingly well for me as far as strength and aggression boosts. In fact a few times I took too much and was all wired and jittery. Just gotta go by feel to find your sweet spot.
 
TB I would really like those workout effects, so will keep trying the prewo dosing for another week or so. After that I will switch to spread out dosing; 1cap every three hrs, 6cap per day. Though I may miss out on the acute effects from single dosing Im hoping the more constant blood levels will result in greater AR stimulation over time.
 
Well lethargy has returned last few days, so looks like that one day was an anomaly.

Have got some derma coming in, until then will continue to experimdent with the oral. Trying 6cap (150mg) prewo tomorow.
 
NAM, please keep us updated I'm very interested to see what you think of the trans with the LGD. I've had serious lethargy from the LGD as well so I switched the dose to around 8pm (ish), by 10pm I'm ready for bed and it actually seems to be working for me as I've slept more soundly the last two days. I'm a little groggy in the morning but it doesn't last too long into the day, especially after I take some noopept, it pretty much disappears.

I wish I had some of the oral version to take pre-workout, I may have to pick some up and give it a try if I can justify it in my head, and bank account.
 
NewAgeMayan said:
Well lethargy has returned last few days, so looks like that one day was an anomaly.

Have got some derma coming in, until then will continue to experimdent with the oral. Trying 6cap (150mg) prewo tomorow.
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You should really try the oral trest with something that doesn't cause so much lethargy...I mean just at least for comparison.
 
hrdgain81 said:
NAM, please keep us updated I'm very interested to see what you think of the trans with the LGD. I've had serious lethargy from the LGD as well so I switched the dose to around 8pm (ish), by 10pm I'm ready for bed and it actually seems to be working for me as I've slept more soundly the last two days. I'm a little groggy in the morning but it doesn't last too long into the day, especially after I take some noopept, it pretty much disappears.

I wish I had some of the oral version to take pre-workout, I may have to pick some up and give it a try if I can justify it in my head, and bank account.
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Its interesting just how much lethargy differs amongst people.

T-Bone said:
You should really try the oral trest with something that doesn't cause so much lethargy...I mean just at least for comparison.
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Yip, this current cycle is very much unlike me, I dont normally run so much stuff at once, especially if it involves compounds I have not run previously.
 
Are the studies on ment, or ment ace ?

What is in dermatrest, ment or ment ace?

What is in oral trest, ment or ment ace?

Op should think about changing his shower routine to once per day, post workout, then applying.
 
After a bit more contemplation and soul searching I have tentatively decided on how I will dose the rest of this Tr3st cycle:

1 week 150mg oral prewo (I train 7 days per wk)

1 week 150mg oral split dosed thru day

4 weeks 100mg td per day, one app evening and one app in morning postwo; 100mg oral prewo
 
NewAgeMayan said:
After a bit more contemplation and soul searching I have tentatively decided on how I will dose the rest of this Tr3st cycle:

1 week 150mg oral prewo (I train 7 days per wk)

1 week 150mg oral split dosed thru day

4 weeks 100mg td per day, one app evening and one app in morning postwo; 100mg oral prewo
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You're waiting for the TD in the mail right?. I think you'll be surprised at how well the TD works at just 50mg(total-2 25 mg applications). Plus it'll last you 8 weeks that way. Not sure how much longer you have for you LGD, but I'm guessing you might feel the trest better once you run out the LGD....Plus I don't know about you but I'd rather stay on longer with a smaller dosage than run a shorter cycle with a higher dosage. It's also my opinion that you'll keep more post cycle that way. Not saying it's fact, just my opinion on things.
 
100mg trest? That's pretty high.

And before bed then again in the morning doesn't sound like a good idea.
I'd imagine sleep is going to really suck.
 
Thanks for the feedback.

In most other scenarios I too would advise, and run myself, a smaller dose of a compound for a longer period.

The dose numbers, though, are by no means set in stone.

This cycle hasnt entirely gone as planned for numerous reasons, so it is what it is (dont really want to extend it).
 
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