Daily Agmatine Sulfate dosing

stan08 said:
I'll probably have to take it just before bed. Was a little reluctant of taking it only then (even if it works for my back pain at once daily dosing) because I would kind of miss the pumped feeling that I get all day. :)

Taking it after a large meal wouldn't affect it's availability? For some reason was thinking it shouldn't be taken near high protein meals. Could have it mixed up with something else though.
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Agmatine is fine with or without food.
 
I like 1g preworkout the best. Sometimes I use 500-1000mg in the morning. I always take it in the morning on off days with my other bulk powders. Im going to try the pre bed dosing in a half hour or so with my rezurrect and see how that is.
 
Sorry for an old thread bump here but trying to figure out the half-life of agmatine effects

Did my own Searching (people still do that???) and found a reference to a 10 minute effect which didn't seem right.
Also one said 2 hours.
Reference was also made to it being able to accumulate as well though.

Looking for any more definitive answers on this if anyone knows
 
Driven2lift said:
Sorry for an old thread bump here but trying to figure out the half-life of agmatine effects

Did my own Searching (people still do that???) and found a reference to a 10 minute effect which didn't seem right.
Also one said 2 hours.
Reference was also made to it being able to accumulate as well though.

Looking for any more definitive answers on this if anyone knows
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The serum half-life (short, as you mentioned) isn't necessarily what we're after with Agmatine. Looks into its CNS half-life, which is much more prolonged.

Here we can see up to 12 hours with a single spinal injection:

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aaronuconn said:
The serum half-life (short, as you mentioned) isn't necessarily what we're after with Agmatine. Looks into its CNS half-life, which is much more prolonged.

Here we can see up to 12 hours with a single spinal injection:

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Click to expand...


single spinal injection....
 
lol, sorry guys, not a whole lot of light has been shed into the agmatinergic system so a rodent study with dosing coming via a intrathecal injection I believe is the best we have to go off of in regards to CNS half-life.

Most of these studies are also administering agmatine systematically vs. the oral route. That's how we're able to see the CNS effects.

I've never seen the full-text, but from the previews Google allows anyone to see, "Pharmacokinetics, Pharmacodynamics and Transport of Agmatine in the Central Nervous System" from John. C Roberts would be a good, comprehensive read.
 
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