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D-Aspartate shown in this study to increase testosterone production!

EricMM

Well-known member
This article shows that Pat Arnold was correct IMHO where D-Aspartate increases testosterone production via enzyme upregulation of activity. Weighted toward testosterone production at the expense of estradiol production!

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Int J Mol Sci. 2016 Jul 14;17(7). pii: E1127. doi: 10.3390/ijms17071127.
Molecular Mechanisms Elicited by d-Aspartate in Leydig Cells and Spermatogonia.

Di Fiore MM1, Santillo A2, Falvo S3, Longobardi S4, Chieffi Baccari G5.
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Abstract
A bulk of evidence suggests that d-aspartate (d-Asp) regulates steroidogenesis and spermatogenesis in vertebrate testes. This review article focuses on intracellular signaling mechanisms elicited by d-Asp possibly via binding to the N-methyl-d-aspartate receptor (NMDAR) in both Leydig cells, and spermatogonia. In Leydig cells, the amino acid upregulates androgen production by eliciting the adenylate cyclase-cAMP and/or mitogen-activated protein kinase (MAPK) pathways. d-Asp treatment enhances gene and protein expression of enzymes involved in the steroidogenic cascade. d-Asp also directly affects spermatogonial mitotic activity. In spermatogonial GC-1 cells, d-Asp induces phosphorylation of MAPK and AKT serine-threonine kinase proteins, and stimulates expression of proliferating cell nuclear antigen (PCNA) and aurora kinase B (AURKB). Further stimulation of spermatogonial GC-1 cell proliferation might come from estradiol/estrogen receptor β (ESR2) interaction. d-Asp modulates androgen and estrogen levels as well as the expression of their receptors in the rat epididymis by acting on mRNA levels of Srd5a1 and Cyp19a1 enzymes, hence suggesting involvement in spermatozoa maturation.

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WHY DIDN'T NMDA work to boost testosterone?

Don't just look at a name and make a snap decision. Oddly enough N-Methyl-D-Aspartate may bind to it BUT NOT ACTIVATE IT! Looks like Glutamate and Glycine activate it but not NMDA. Would make some sense with this study:

J Sports Sci Med. 2014 Jan 20;13(1):192-9. eCollection 2014 Jan.
Heavy Resistance Training and Supplementation With the Alleged Testosterone Booster Nmda has No Effect on Body Composition, Muscle Performance, and Serum Hormones Associated With the Hypothalamo-Pituitary-Gonadal Axis in Resistance-Trained Males.

Willoughby DS1, Spillane M1, Schwarz N1.
Author information
Abstract
The effects of 28 days of heavy resistance training while ingesting the alleged testosterone-boosting supplement, NMDA, were determined on body composition, muscle strength, serum cortisol, prolactin, and hormones associated with the hypothalamo-pituitary- gonadal (HPG) axis. Twenty resistance-trained males engaged in 28 days of resistance training 4 times/wk while orally ingesting daily either 1.78 g of placebo (PLAC) or NMDA. Data were analyzed with separate 2 x 2 ANOVA (p < 0.05). Criterion measures involved body composition, muscle strength, serum cortisol, prolactin, and gonadal hormone levels [free and total testosterone, luteininzing hormome (LH), gonadotrophin releasing hormone (GnRH), estradiol], and were assessed before (Day 0) and after (Day 29) resistance training and supplementation. No changes were noted for total body water and fat mass in response to resistance training (p > 0.05) or supplementation (p > 0.05). In regard to total body mass and fat-free mass, however, each was significantly increased in both groups in response to resistance training (p < 0.05), but were not affected by supplementation (p > 0.05). In both groups, lower-body muscle strength was significantly increased in response to resistance training (p < 0.05); however, supplementation had no effect (p > 0.05). All serum hormones (total and free testosterone, LH, GnRH, estradiol, cortisol, prolactin) were unaffected by resistance training (p > 0.05) or supplementation (p > 0.05). The gonadal hormones and cortisol and prolactin were unaffected by 28 days of NMDA supplementation and not associated with the observed increases in muscle strength and mass. At the dose provided, NMDA had no effect on HPG axis activity or ergogenic effects in skeletal muscle. Key PointsIn response to 28 days of heavy resistance training and NMDA supplementation, similar increases in muscle mass and strength in both groups occurred; however, the increases were not different between supplement groups.The supplementation of NMDA had no preferential effect on augmenting testosterone or decreasing estrogen, cortisol, and prolactin.While resistance training was effective in increasing muscle mass and strength, it was not preferentially due to NMDA supplementation.At the dose provided, NMDA supplementation for 28 days combined with resistance training does not increases muscle mass and strength due to its ability to elevate endogenous testosterone levels and lower cortisol and prolactin when compared to placebo.

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I personally think it works well for those with LOW TEST to begin with. I have associates and those with low levels, for whatever reason age/PCT, respond. Those with normal levels usually get jack. As long as we know this and the right people use it IMO it has value.
 
well, here's the thing I have been explaining. I think the body modulates the receptor based on your levels. Too low and it upregulates the receptor and too high we get down regulation.

I think once the threshold is crossed (juice or prohormones) then we see that actual body transformations occur! Thus, I don't think boosting testosterone itself is really beneficial unless you cross that 1200 ng/dl threshold.

In the Novedex XT study we saw that the natural barrier is 1200 ng/dl
 
Eric Mar said:
I think once the threshold is crossed (juice or prohormones) then we see that actual body transformations occur! Thus, I don't think boosting testosterone itself is really beneficial unless you cross that 1200 ng/dl threshold.

In the Novedex XT study we saw that the natural barrier is 1200 ng/dl
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Free test would probably be a much more significant measure. Total test is obviously crucial but as a yardstick can be too crude an indicator.
 
Nac said:
Free test would probably be a much more significant measure. Total test is obviously crucial but as a yardstick can be too crude an indicator.
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Someone with a total test of 800 and a low free test, boosting free testosterone can improve mood, health and muscle.

Im a big advocate of sodium D aspartic acid because Ive had blood-work afterward two weeks on it, twice, while my test was low, and those were the only times my total testosterone rose. In addition, I took it for eleven months from 2011-2012, and my testes significantly increased, and my ex-girlfriend noticed. I am on trt now, and I see a nice increase in testes size, after a week to two weeks.
 
John Smeton said:
Someone with a total test of 800 and a low free test, boosting free testosterone can improve mood, health and muscle.

Im a big advocate of sodium D aspartic acid because Ive had blood-work afterward two weeks on it, twice, while my test was low, and those were the only times my total testosterone rose. In addition, I took it for eleven months from 2011-2012, and my testes significantly increased, and my ex-girlfriend noticed. I am on trt now, and I see a nice increase in testes size, after a week to two weeks.
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I notice the same. Stack an AI with it and never look back. I take it 5 days a week.
 
Nac said:
Free test would probably be a much more significant measure. Total test is obviously crucial but as a yardstick can be too crude an indicator.
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I agree, but most people test TOTAL and not free test. Free test is the most important factor since SHBG can play a major factor.
 
Well, at least there are 3 of you it worked for. Still sits upon my pile of worthless crap supplements.
 
This study is in rats. Human studies are less promising in regard to testosterone. I'd take a human study over a rat any day.
 
Eric Mar said:
Yeah, unfortunately the only human studies use D-Aspartic Acid.
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The mechanism of action is still the same. It would make sense if it changed, but not in this case.
 
kisaj said:
Well, at least there are 3 of you it worked for. Still sits upon my pile of worthless crap supplements.
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I hear you, hell even if it was blowing 99% of people away if it does jack sh*t for you no point in taking. SOoooooo, you wanna send it all to me? I'll pay shipping!
 
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