NAC and vitamin C has been recommended here by a bunch of people including Marc Mcdougal as a great combo for visceral fat loss[1] , but this article says it dangerous:
http://www.unisci.co...013/0927015.htm
"Initially, the vitamin C and NAC were given to prevent the injury, because we thought they'd have protective effects," Leeuwenburgh said. "Instead, they were damaging."
Leeuwenburgh attributes the damaging effects of the vitamin C and NAC to their reaction with iron in the body. Normally, iron is bound to proteins and enzymes and therefore can't react with vitamin C and NAC.
But when inflammation occurs -- as it does in muscular injuries and a variety of diseases such as Alzheimer's, arthritis and cardiovascular disease -- the body releases more free iron, which is highly reactive to outside elements -- in this case, vitamin C and NAC. Indeed, the researchers showed that there were increases in free iron following this type of exercise.
"Vitamin C isn't bad, and neither is NAC, but by some mechanism in this situation there were some pro-oxidant effects of supplementation," said April Childs, a graduate student in the department of exercise and sport sciences and the lead author of the study.
And although Leeuwenburgh says people who have taken vitamin C or NAC in the past shouldn't worry too much about the new finding, he recommends caution in supplementing vitamin C in doses greater than 100 mg after injuries or disease condition characterized by increases in free iron.
"People should limit their vitamin C intake until we know more," he said. "Everyone agrees that after 80 to 90 milligrams, about the recommended daily allowance, it goes out of your body since measurements show that white blood cells are saturated completely after this dose. You'd think that if it goes out of your body it isn't harmful, but maybe the high transient levels do react in a negative way. There's no benefit to taking more than the RDA, and it could actually harm you."
Furthermore, he said, "Vitamin C is believed to prevent cancer, but instead, it may be damaging. Studies performed in humans actually show that it may increase DNA damage."
Because vitamin C and NAC in the body appear to react most negatively with iron, Leeuwenburgh said, those with inflammatory diseases and those who take more than the recommended daily allowance of iron should be particularly vigilant about limiting their vitamin C and NAC intake.
"If you're taking more than the RDA of iron, you're putting yourself at risk by taking more than the RDA of vitamin C or NAC at the same time," Leeuwenburgh said. "Iron is very important in preventing anemia. So many people -- particularly women -- are supplementing, and the effects of supplementing iron and vitamin C for long periods have not been adequately studied.