hazard12
Well-known member
This is taken from examine.com:
"Cordyceps can reduce HcG and cAMP-stimulated steroidogenesis (via PKA and possibly inhibiting P450scc by 30%, the enzyme that converts cholesterol to pregnenolone).[22] This same study showed that Cordyceps did not reduce testosterone production when coincubated with androstenedione or pregnenolone, suggesting it does not influence enzymes in the later portion of steroidogenesis.[22] Interestingly, this study also showed that Cordyceps was able to inhibit Forskolin-induced steroidogenesis, which is cAMP-induced and how the herb Coleus Forskohlii
Coleus forskohlii is an herb used in traditional medicine that may boost testosterone and induce fat loss, particularly in men.
increases testosterone.[22] This inhibition of testosterone synthesis stimulated by cAMP and HcG has been noted elsewhere,[23][24] and inhibition of PKA abolishes the effects of Cordyceps.[25]"
"In cells not intentionally stimulated with HcG, Corcyceps extract reliably increases testosterone secretions from cells with an ideal concentration of 3mg/mL, shown in two separate studies on dose-response.[16][23] Concentrations greater than 10mg/mL are associated with declines in testosterone related to baseline.[23] Protein fragments in Cordyceps have been implicated in being the active compounds[16] although Cordycepin appears to be active as well.[25] Feeding isolated Cordycepin at 40mg/kg bodyweight does not increase testosterone in vivo, however, yet it does when injected suggesting poor bioavailability.[25]"
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From this data, id say that cordyceps is a bad idea for off cycle, but it should be very interesting for on cycle. Theres a chance it can keep your balls semi plump and/or producing testosterone, although at a reduced rate probably. Even if the amount of test isnt that relevant, it might help you restart your balls easier, particularly during long cycles.
Im curious to see what other people think,
"Cordyceps can reduce HcG and cAMP-stimulated steroidogenesis (via PKA and possibly inhibiting P450scc by 30%, the enzyme that converts cholesterol to pregnenolone).[22] This same study showed that Cordyceps did not reduce testosterone production when coincubated with androstenedione or pregnenolone, suggesting it does not influence enzymes in the later portion of steroidogenesis.[22] Interestingly, this study also showed that Cordyceps was able to inhibit Forskolin-induced steroidogenesis, which is cAMP-induced and how the herb Coleus Forskohlii
Coleus forskohlii is an herb used in traditional medicine that may boost testosterone and induce fat loss, particularly in men.
increases testosterone.[22] This inhibition of testosterone synthesis stimulated by cAMP and HcG has been noted elsewhere,[23][24] and inhibition of PKA abolishes the effects of Cordyceps.[25]"
"In cells not intentionally stimulated with HcG, Corcyceps extract reliably increases testosterone secretions from cells with an ideal concentration of 3mg/mL, shown in two separate studies on dose-response.[16][23] Concentrations greater than 10mg/mL are associated with declines in testosterone related to baseline.[23] Protein fragments in Cordyceps have been implicated in being the active compounds[16] although Cordycepin appears to be active as well.[25] Feeding isolated Cordycepin at 40mg/kg bodyweight does not increase testosterone in vivo, however, yet it does when injected suggesting poor bioavailability.[25]"
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From this data, id say that cordyceps is a bad idea for off cycle, but it should be very interesting for on cycle. Theres a chance it can keep your balls semi plump and/or producing testosterone, although at a reduced rate probably. Even if the amount of test isnt that relevant, it might help you restart your balls easier, particularly during long cycles.
Im curious to see what other people think,