Change of supplement since testing my genetics.....

[bell1986]

Morning folks

How are we all?

I've took tons of supplements over the years. I enjoyed playing with new compounds all the time. You know that feeling.

Well recently I paid and got a 23andme done and I started to learn to read Raw SNP genetic data. I dived deep into mine and it explained so much about supplement effects on me.

I found I have an SNP that causes me to break down Dopamine/Serotonin/Norepinephrine much slower than the average person. I always wondered why I had anxiety a lot and this actually explained a lot to me. I have naturally high dopamine levels due to the slow breakdown.

I genuinely never clicked that any sort of supplement that affected dopamine. L-phenyalinine ' L-Tyrosine' L-Dopa ' Bromantane and even the likes of Rhodiola Rosea would all give me borderline anxiety. Not major but noticeable.

Since finding out these genetic issues ive drastically changed any supplements I take. My body doesn't tolerate methyl donors well at all and my multivitamin (Which I thought was being healthy) was actually causing issues. I now take a non methylated vitamin complex (Game changer). I also have the classic MTHFR gene mutation. I also can't handle methyl donors so I found a non methylated folate (Another game changer).

Use don't need to but I honestly believe that doing your genetics and finding out how your brain is actually working is well worth it before throwing supplements at yourself.

I've changed all the supplements I now take based on these genes and I feel the best I ever have.

Has anyone else done this? I think it's a great idea to do. We're all taking supplements based on what their 'Suppose' to do. They function very different in everyone. Hence why some say. This supplement is junk it does nothing.

If you do a gene panel and need help then I would happily help I've done a lot of research into a lot of the SNP's and can read and interpret them very well. Their are a few sites that do genetics. It's very cheap now also. Honestly in my opinion. It's been the best thing I've done for my health. I now understand my body. Though... It's not perfect. Even though a gene says this. Your body can still function differently from what this depicts. We're all unique.

Just pm me if you need help

 

[GreenMachineX]

Morning folks

How are we all?

I've took tons of supplements over the years. I enjoyed playing with new compounds all the time. You know that feeling.

Well recently I paid and got a 23andme done and I started to learn to read Raw SNP genetic data. I dived deep into mine and it explained so much about supplement effects on me.

I found I have an SNP that causes me to break down Dopamine/Serotonin/Norepinephrine much slower than the average person. I always wondered why I had anxiety a lot and this actually explained a lot to me. I have naturally high dopamine levels due to the slow breakdown.

I genuinely never clicked that any sort of supplement that affected dopamine. L-phenyalinine ' L-Tyrosine' L-Dopa ' Bromantane and even the likes of Rhodiola Rosea would all give me borderline anxiety. Not major but noticeable.

Since finding out these genetic issues ive drastically changed any supplements I take. My body doesn't tolerate methyl donors well at all and my multivitamin (Which I thought was being healthy) was actually causing issues. I now take a non methylated vitamin complex (Game changer). I also have the classic MTHFR gene mutation. I also can't handle methyl donors so I found a non methylated folate (Another game changer).

Use don't need to but I honestly believe that doing your genetics and finding out how your brain is actually working is well worth it before throwing supplements at yourself.

I've changed all the supplements I now take based on these genes and I feel the best I ever have.

Has anyone else done this? I think it's a great idea to do. We're all taking supplements based on what their 'Suppose' to do. They function very different in everyone. Hence why some say. This supplement is junk it does nothing.

If you do a gene panel and need help then I would happily help I've done a lot of research into a lot of the SNP's and can read and interpret them very well. Their are a few sites that do genetics. It's very cheap now also. Honestly in my opinion. It's been the best thing I've done for my health. I now understand my body. Though... It's not perfect. Even though a gene says this. Your body can still function differently from what this depicts. We're all unique.

Just pm me if you need help

Sounds like you have COMT mutations? I figured out last year that's why methyl b vitamins feel like amphetamine to me.

 

[bell1986]

Sounds like you have COMT mutations? I figured out last year that's why methyl b vitamins feel like amphetamine to me.

Yes I have the slow comt mutation.

I was the exact same. I bought a multivitamin that was all methyl B's and I couldn't click on why I had anxiety all the time. After I learned I had that mutation I looked at all my methyl donors and any form of dopamine/Serotonin supplements and dropped them. A few days later I woke with such a relief of anxiety. I was like wow I never knew I felt so garbage for so long.

I've added in different supp's that support comt also and it's been great.

What have you done for your mutation? Are you similar to me and suffer anxiety a lot?

Any recommendations or supplements and or diet change etc you found very helpful?

 

[GreenMachineX]

Yes I have the slow comt mutation.

I was the exact same. I bought a multivitamin that was all methyl B's and I couldn't click on why I had anxiety all the time. After I learned I had that mutation I looked at all my methyl donors and any form of dopamine/Serotonin supplements and dropped them. A few days later I woke with such a relief of anxiety. I was like wow I never knew I felt so garbage for so long.

I've added in different supp's that support comt also and it's been great.

What have you done for your mutation? Are you similar to me and suffer anxiety a lot?

Any recommendations or supplements and or diet change etc you found very helpful?

What have you added in to support COMT that were beneficial?

The past 18 months have been hell and only recently have I really nailed a few things down and made some progress. Not just anxiety, but insomnia of the zero sleep variety for quite a while. I don't have mthfr, but I do have dhfr mutation which helps recycle folate, and I mtrr mutation which helps recycle b12, so it's ready for me to be deficient in both.

Some of the things that Make mine worse:
-Too much vegetable folate
-too much vitamin C
-All supplemental B vitamins
-any form of magnesium
-too many eggs
-working deadlift and squat too hard
-too large of a caloric deficit

Some things that help, or at least don't hurt:
-enriched foods like rice
-2 to 3 eggs per day
-50-100mg niacin per day (this is huge for pushing folate/methylation too hard)
-Pumpkin seeds for magnesium
-Eating enough carbs

Eggs are one of the biggest influences every day for me, and the amount of niacin I need to balance it. No eggs and I'm unmotivated/lethargic/hard to function, 2 to 3 eggs and I feel decent, fair motivation and pretty good mood, >3 eggs and I'm flying high for a few hours but eventually anxiety and irritability creep in pretty hard, and need to dose 50mg niacin a few times over a few hours to come back down.

Cyanocobalamin injections haven't been a problem while treating the deficiencies. I haven't figured everything but it's been a difficult road.

 

[GreenMachineX]

I should also mention the I used to take basically everything we discuss on this forum, but now, literally everything gives me some kind of unpleasant side effect so I'm down to cyano b12, D3 and K2 MK7, niacin and just dropped fish oil. I use lunesta every night to sleep after a year of hardcore insomnia.

 

[rowz4broz]

very cool to come across this thread, I am a literaly just bought a 23 & me like 2 hours ago haha

 

[bell1986]

What have you added in to support COMT that were beneficial?

The past 18 months have been hell and only recently have I really nailed a few things down and made some progress. Not just anxiety, but insomnia of the zero sleep variety for quite a while. I don't have mthfr, but I do have dhfr mutation which helps recycle folate, and I mtrr mutation which helps recycle b12, so it's ready for me to be deficient in both.

Some of the things that Make mine worse:
-Too much vegetable folate
-too much vitamin C
-All supplemental B vitamins
-any form of magnesium
-too many eggs
-working deadlift and squat too hard
-too large of a caloric deficit

Some things that help, or at least don't hurt:
-enriched foods like rice
-2 to 3 eggs per day
-50-100mg niacin per day (this is huge for pushing folate/methylation too hard)
-Pumpkin seeds for magnesium
-Eating enough carbs

Eggs are one of the biggest influences every day for me, and the amount of niacin I need to balance it. No eggs and I'm unmotivated/lethargic/hard to function, 2 to 3 eggs and I feel decent, fair motivation and pretty good mood, >3 eggs and I'm flying high for a few hours but eventually anxiety and irritability creep in pretty hard, and need to dose 50mg niacin a few times over a few hours to come back down.

Cyanocobalamin injections haven't been a problem while treating the deficiencies. I haven't figured everything but it's been a difficult road.

Hey

That's very surprising regarding the Magnesium and Vitamin C. Both these are utilised to help the COMT enzyme to function.

I personally bumped my magnesium dose and noticed a nice bump in mood. I also noticed a big change from using Creatine and Vitamin C.

We sound very similar. Every supplement now just makes me feel like garbage. Methyl B's make me feel all on edge. I honestly never even thought my multi was actually making me very ill.

I might try the eggs. I do occasionally eat eggs but never actually tested them in terms of my mood.

I've just ordered Niacin also. I've read all positives about it.

Have you thought about Sam-e? I've heard people having success with this. Not all but some.

I notice if I train too hard I feel hellish also. Is this linked to our issue? I now just train lightish but still hypertrophic.

Any other suggestions? I'm actually tired of feeling anxious and tired etc. I'm glad I know roughly what's going on. I'm gonna keep looking and experimenting to see if I can feel semi normal.

Do you also get the hangover effect? Like a day after drinking alcohol you feel much better in terms of socialising etc? People with our mutation get this. I get it. Alcohol hangovers make me feel the best lol

 

[GreenMachineX]

Hey

That's very surprising regarding the Magnesium and Vitamin C. Both these are utilised to help the COMT enzyme to function.

I personally bumped my magnesium dose and noticed a nice bump in mood. I also noticed a big change from using Creatine and Vitamin C.

We sound very similar. Every supplement now just makes me feel like garbage. Methyl B's make me feel all on edge. I honestly never even thought my multi was actually making me very ill.

I might try the eggs. I do occasionally eat eggs but never actually tested them in terms of my mood.

I've just ordered Niacin also. I've read all positives about it.

Have you thought about Sam-e? I've heard people having success with this. Not all but some.

I notice if I train too hard I feel hellish also. Is this linked to our issue? I now just train lightish but still hypertrophic.

Any other suggestions? I'm actually tired of feeling anxious and tired etc. I'm glad I know roughly what's going on. I'm gonna keep looking and experimenting to see if I can feel semi normal.

Do you also get the hangover effect? Like a day after drinking alcohol you feel much better in terms of socialising etc? People with our mutation get this. I get it. Alcohol hangovers make me feel the best lol

After developing an addiction to GABA-type drugs years ago, I no longer drink or anything at all. I responded far too well to them.

I haven't tried SAMe in a long time, eventually I will again.

I think my issue with Vitamin C is it lowers cortisol too low for me, but I'm not sure. No idea why magnesium wakes me up in the middle of the night.

I think the intensity of workouts effects us because it stimulates NE and DA, and we have trouble clearing it out. I always leave the gym feeling revved up, never tired and it lasts for hours. But, I maxed on DL yesterday and actually fell pretty well today, and slept about 7.5 hours only waking up twice. That's a new record lol. The past few workouts have been getting better..I think because I've increased my carbs quite a bit, eating more folic acid in food, and possibly dropping the fish oil. I do think raising my b12 has been helping also.

I'll keep posting if I find anything else helpful.

 

[poison]

I love the premise here, and while I think it's wise to utilize this for this purpose, I have one reservation: giving my DNA to some random corporation with iffy privacy practices and an obligation to share with gov't agencies should they require it.

Privacy Problems of Direct-to-Consumer Genetic Testing | DNA Tests - Consumer Reports

When it comes to the privacy of the intimate DNA data you share with them, direct-to-consumer (DTC) genetic testing companies make promises such as, “your privacy comes first,” and, “protecting your privacy is at the core of what we do.”
But when you use their services, genetic testing companies collect more than just your DNA. They, like many other companies, collect a wide variety of other personal data, including information you share with them such as your name, basic identifiers like your address and email address, and, in some cases, facts about your family and your health.
When it comes to this kind of non-DNA data, an investigation by Consumer Reports has found that direct-to-consumer genetic testing companies employ policies and practices that our experts think unnecessarily compromise consumers’ privacy. While our analysis suggests that for the most part, these companies do a relatively decent job of protecting your DNA data (at least according to their stated privacy policies), we found that the many types of non-DNA data they gather are not treated with the same care. The companies’ services over-collect personal information about you and overshare some of your data with third parties. CR’s privacy experts say it’s unclear why collecting—and then sharing—much of this data is necessary to provide you the services they offer.

During covid, covid testing companies were found to be sharing masses of data with china:

Sheriff Villanueva won't use county's COVID test provider over its alleged China ties - Los Angeles Times (latimes.com)

China Wants Your Data — And May Already Have It : NPR

As COVID cases began to rise a year ago, a Chinese company contacted several U.S. states and offered to set up testing labs. As a byproduct, the Chinese firm, Beijing Genomics Institute, would likely gain access to the DNA of those tested.
The offer was tempting for states struggling to set up their own testing facilities for a new virus on short notice. But U.S. national security officials urged the states to reject the offer, citing concerns about how China might use personal data collected on Americans.
"We certainly reached out to our partners and the community to make sure people were aware that the Chinese were pushing out these tests, informing them of what the risks were and really asking them not to take these tests," said Mike Orlando, the head of the National Counterintelligence and Security Center, which is part of the Office of the Director of National Intelligence.


WORLD
What Trump's Declassified Asia Strategy May Mean For U.S.-China Relations Under Biden
"As far as I know, they all turned them down," Orlando added.
Meanwhile, Beijing Genomics Institute, a major global player in the world of genomics research, reportedly set up labs in at least 18 other countries, and provided COVID testing kits to 180 nations, including the U.S. The U.S. officials stressed that their main concern was preventing the establishment of full-service labs. The officials do not consider the testing kits to pose a serious risk.
Biotech companies in China, the U.S. and elsewhere routinely collect DNA data and use it to help guide the development of cutting-edge medicines that can benefit people worldwide. And BGI says it abides by all the laws in countries where it operates.
However, human rights groups say the Chinese government uses DNA testing for security purposes — such as identifying and tracking Uigher Muslims, the ethnic and religious minority whose members are being held in detention camps, in huge numbers, in western China.
Chinese police are also working to gather DNA samples from the country's male population — numbering roughly 700 million — to help keep tabs on the half of the population most likely to commit crimes, The New York Times reported last year.
A sweeping effort
U.S. officials add that DNA collection by Chinese companies, even when done openly and legally, should be seen as part of a comprehensive effort to vacuum up millions and millions of records on U.S. citizens. And many Chinese efforts violate U.S. law, the officials say.
"Most Americans have probably had their data compromised by the cyber intelligence units of the Chinese government and Chinese military intelligence," said April Falcon Doss who worked at the National Security Agency and wrote the book Cyber Privacy:Who Has Your Data And Why You Should Care.

Falcon Doss said China is collecting detailed personal information on a massive scale for multiple reasons: to boost its economy, advance its technology and to support its espionage efforts.

Giving china more DNA with which to better dial in their next hit release (covid 23? 24?), or the US gov't to do <insert whatever it is is irrelevant>, seems like a very bad idea. So, as much as I'd like to, I'll pass.

 

[poison]

Damn, I didn't mean to completely shut this down! lol Seriously, it's a super interesting topic.

 

[GreenMachineX]

Damn, I didn't mean to completely shut this down! lol Seriously, it's a super interesting topic.

It's not a popular topic yet...it's almost like every other possible cause to feeling bad has to be explored before this is looked into.

I have wondered what @sns8778 thinks though about COMT and such.

 

[Resolve10]

I think it is relatively cool and definitely something that could be useful in the future.

I do have reservations (I haven't looked into it a ton super recently though so may be behind) because (with many things) I can see how people may start marketing things based on testing that don't really have the appropriate science behind the claims they'll make (but that is just me being pessimistic).

I think some things like what you've noticed, genes showing different reactions to stuff like caffeine, etc. may have merit now and even more as we learn more. I'd just caution making to strong of decisions or inferences on things where singular genes and their actual effects probably haven't been fully teased out (not even getting into anything about how accurate the results you get from these tests even may be for certain things).

 

[sns8778]

I think it is relatively cool and definitely something that could be useful in the future.

I do have reservations (I haven't looked into it a ton super recently though so may be behind) because (with many things) I can see how people may start marketing things based on testing that don't really have the appropriate science behind the claims they'll make (but that is just me being pessimistic).

I think some things like what you've noticed, genes showing different reactions to stuff like caffeine, etc. may have merit now and even more as we learn more. I'd just caution making to strong of decisions or inferences on things where singular genes and their actual effects probably haven't been fully teased out (not even getting into anything about how accurate the results you get from these tests even may be for certain things).

Good post and I absolutely agree. I think that these things can be useful tools but not enough is yet known about them to know the overall big picture of things to make but so many blanket overviews based on them.

 

[sns8778]

Damn, I didn't mean to completely shut this down! lol Seriously, it's a super interesting topic.

I just wasn't commenting - because the reason you posted (privacy) is the reason that I haven't done any of the send in testing things. I have had testing done, but mine was ordered by my physician in the past. I think privacy, like all things, is a very personalized thing - extremely important to some but others not so much so.

 

[sns8778]

It's not a popular topic yet...it's almost like every other possible cause to feeling bad has to be explored before this is looked into.

I have wondered what @sns8778 thinks though about COMT and such.

There's too much on the topic to go into detail on it in a post, and I've generally cut back on my super long posting recently because activity here has really died over the last couple of months, so a lot of the things I used to would post very long and detailed posts on, I'm writing articles about now to start releasing in a couple months.

But glad to give opinions as to specific aspects of it - what part of it were you curious about my opinion on?

 

[GreenMachineX]

There's too much on the topic to go into detail on it in a post, and I've generally cut back on my super long posting recently because activity here has really died over the last couple of months, so a lot of the things I used to would post very long and detailed posts on, I'm writing articles about now to start releasing in a couple months.

But glad to give opinions as to specific aspects of it - what part of it were you curious about my opinion on?

Any of your thoughts on COMT specifically would be greatly appreciated.

 

[sns8778]

Any of your thoughts on COMT specifically would be greatly appreciated.

Sorry, that's what I meant by it being such a broad topic - I have a lot of thoughts on it overall, but its way too broad of a topic to go but so much into, but I typed up some observations for you below.

I think that there is a lot of information being thrown out on it as absolutes that aren't - because research is still evolving and ongoing on it.

Overall observations would be:

• It can cause increased levels of cortisol.
• It can limit the body's ability to cope with stress (physical or mental)
• I think the effects it can have on mood can vary greatly from person to person and I think there is likely a lot more to it than they know now and that too many generalizations are being made.
• I think that many of the supplement suggestions being thrown around for it are largely just sales pitches and companies trying to cash in off of it - I do think there are some good supplement options for it, but I plan on turning that into an article after more research - but I did mention some of it in the thread I made on MTHF awhile back.
• There is some info about reducing consumption of certain amino acids - some I agree with, some I don't; but overall, I think that there are pro's and con's to this in general. Although I would say that I agree with not dosing Tryptophan and Phenylalanine too high; not with eliminating it, but I wouldn't intentionally use an EAA that had over 250 mg. of it in it for example.
• I think that it can make people more predisposed to higher estrogen levels and that supplements like Inhibit-E can be a great daily health addition for people with this mutation.
• I disagree with the people that say to avoid tea and green tea - one has to find a balance between enough to be healthy and not overdoing it.
• I think that SAMe can be very beneficial for many people with this mutation BUT a lot of SAMe products on the market don't meet label claims. I would only use the NOW Foods SAMe, and I do use that - 400 mg. once per day in morning.
• Some articles seem to use this mutation as a cop out to avoid exercise - I disagree with that because exercising has so many overall health benefits. Instead, I think people should continue to exercise normally but avoid overtraining and emphasize the importance of recovery supplements, like I think that Recovery Fix is a perfect product for people with this mutation.
• I think that because this mutation effects the body's ability to detoxify, I think that supplements like Liver Assist XT and Kidney Assist XT are even more useful for these people and can be used year round by them or at a minimum that they should be used for at least one month every 3 to 4 months.

 

[NattyDaddy420]

Morning folks

How are we all?

I've took tons of supplements over the years. I enjoyed playing with new compounds all the time. You know that feeling.

Well recently I paid and got a 23andme done and I started to learn to read Raw SNP genetic data. I dived deep into mine and it explained so much about supplement effects on me.

I found I have an SNP that causes me to break down Dopamine/Serotonin/Norepinephrine much slower than the average person. I always wondered why I had anxiety a lot and this actually explained a lot to me. I have naturally high dopamine levels due to the slow breakdown.

I genuinely never clicked that any sort of supplement that affected dopamine. L-phenyalinine ' L-Tyrosine' L-Dopa ' Bromantane and even the likes of Rhodiola Rosea would all give me borderline anxiety. Not major but noticeable.

Since finding out these genetic issues ive drastically changed any supplements I take. My body doesn't tolerate methyl donors well at all and my multivitamin (Which I thought was being healthy) was actually causing issues. I now take a non methylated vitamin complex (Game changer). I also have the classic MTHFR gene mutation. I also can't handle methyl donors so I found a non methylated folate (Another game changer).

Use don't need to but I honestly believe that doing your genetics and finding out how your brain is actually working is well worth it before throwing supplements at yourself.

I've changed all the supplements I now take based on these genes and I feel the best I ever have.

Has anyone else done this? I think it's a great idea to do. We're all taking supplements based on what their 'Suppose' to do. They function very different in everyone. Hence why some say. This supplement is junk it does nothing.

If you do a gene panel and need help then I would happily help I've done a lot of research into a lot of the SNP's and can read and interpret them very well. Their are a few sites that do genetics. It's very cheap now also. Honestly in my opinion. It's been the best thing I've done for my health. I now understand my body. Though... It's not perfect. Even though a gene says this. Your body can still function differently from what this depicts. We're all unique.

Just pm me if you need help

I have my 23 and me, how did you get a deeper explanation of everything? Mine only shows a very basic overview. Apparently I have some gene called ACTN3 or something that's useful for strength athletes but idk how relevant that actually is.

 

[GreenMachineX]

I have my 23 and me, how did you get a deeper explanation of everything? Mine only shows a very basic overview. Apparently I have some gene called ACTN3 or something that's useful for strength athletes but idk how relevant that actually is.

If you download your raw data and run it through genetic genie or something similar, it'll break it all down.

 

[bell1986]

Sorry, that's what I meant by it being such a broad topic - I have a lot of thoughts on it overall, but its way too broad of a topic to go but so much into, but I typed up some observations for you below.

I think that there is a lot of information being thrown out on it as absolutes that aren't - because research is still evolving and ongoing on it.

Overall observations would be:

• It can cause increased levels of cortisol.
• It can limit the body's ability to cope with stress (physical or mental)
• I think the effects it can have on mood can vary greatly from person to person and I think there is likely a lot more to it than they know now and that too many generalizations are being made.
• I think that many of the supplement suggestions being thrown around for it are largely just sales pitches and companies trying to cash in off of it - I do think there are some good supplement options for it, but I plan on turning that into an article after more research - but I did mention some of it in the thread I made on MTHF awhile back.
• There is some info about reducing consumption of certain amino acids - some I agree with, some I don't; but overall, I think that there are pro's and con's to this in general. Although I would say that I agree with not dosing Tryptophan and Phenylalanine too high; not with eliminating it, but I wouldn't intentionally use an EAA that had over 250 mg. of it in it for example.
• I think that it can make people more predisposed to higher estrogen levels and that supplements like Inhibit-E can be a great daily health addition for people with this mutation.
• I disagree with the people that say to avoid tea and green tea - one has to find a balance between enough to be healthy and not overdoing it.
• I think that SAMe can be very beneficial for many people with this mutation BUT a lot of SAMe products on the market don't meet label claims. I would only use the NOW Foods SAMe, and I do use that - 400 mg. once per day in morning.
• Some articles seem to use this mutation as a cop out to avoid exercise - I disagree with that because exercising has so many overall health benefits. Instead, I think people should continue to exercise normally but avoid overtraining and emphasize the importance of recovery supplements, like I think that Recovery Fix is a perfect product for people with this mutation.
• I think that because this mutation effects the body's ability to detoxify, I think that supplements like Liver Assist XT and Kidney Assist XT are even more useful for these people and can be used year round by them or at a minimum that they should be used for at least one month every 3 to 4 months.

Hey SNS

Thanks for all your info. Golden as always.

Do you think that the Inhibit-E you guys produce would control estrogen and not crash it?

My issue is.. My TRT throws my estrogen all over the place (Could be my COMT issue. Not 100% certain). I done bloods last week and my estrogen was rocketed. I have Aromasin at hand but I don't like using it as honestly 1mg too much and estrogen plummets. Such a powerful drug.

Do you think that Inhibit-E would keep estrogen lower but not run it into the ground?

Thanks

 

[bell1986]

I have my 23 and me, how did you get a deeper explanation of everything? Mine only shows a very basic overview. Apparently I have some gene called ACTN3 or something that's useful for strength athletes but idk how relevant that actually is.

The actual 23andme report is poor. You need to read the raw data. All your genetics are all hidden in their.

Genetic genie is a good free one and theirs also prometheus that's a chargeable service that's all very detailed.

Once you begin to learn it. It becomes very addictive and you dig and dig. Though. I've learned so much about myself. It's made me change so much in my supplement regimen and I feel so much better. Not perfect but definitely an improvement.

 

[WhatsaBench]

Since 23andme already has my data I figured it would be interesting to see what gentic genie says. I could see how digging into the research could be addicting, apparently I am in the club with you guys with the COMT issue as well as a DVR variant. What I also find fascinating is how this basically confirms for me a lot of the supplement experimentation I have expereinced ( adding high dose D during the winter and using a sleep aid with L-dopa a couple times a week for example).

 

[bell1986]

Since 23andme already has my data I figured it would be interesting to see what gentic genie says. I could see how digging into the research could be addicting, apparently I am in the club with you guys with the COMT issue as well as a DVR variant. What I also find fascinating is how this basically confirms for me a lot of the supplement experimentation I have expereinced ( adding high dose D during the winter and using a sleep aid with L-dopa a couple times a week for example).

Does L-Dopa and any sort of pre workout make you feel anxious or on edge?

I use to take them all and wondered why I never felt good. L-Tyrosine - Mucuna etc. Just anxiety and a mild crash.

Even coffee can over stimulate us.

You gonna change any of your supplement choices now?

 

[WhatsaBench]

Does L-Dopa and any sort of pre workout make you feel anxious or on edge?

I use to take them all and wondered why I never felt good. L-Tyrosine - Mucuna etc. Just anxiety and a mild crash.

Even coffee can over stimulate us.

You gonna change any of your supplement choices now?

I feel like I don't need to change much as I am already taking a lot of what I saw recommended for this variant. Weirdly I think I fall into the lower dopamine camp as things like stimulants tend to bring me up to baseline. This is definitely something I am going to have to keep digging into and experimenting with.

 

[sns8778]

Hey SNS

Thanks for all your info. Golden as always.

Do you think that the Inhibit-E you guys produce would control estrogen and not crash it?

My issue is.. My TRT throws my estrogen all over the place (Could be my COMT issue. Not 100% certain). I done bloods last week and my estrogen was rocketed. I have Aromasin at hand but I don't like using it as honestly 1mg too much and estrogen plummets. Such a powerful drug.

Do you think that Inhibit-E would keep estrogen lower but not run it into the ground?

Thanks

Yes, that is exactly what Inhibit-E is designed for - to help your body regulate and metabolize estrogen better without dropping it too low and with no crash or rebound.

Inhibit-E is a very popular product and a lot of the people that use it use it with their TRT regimens in order to help keep their estrogen levels more consistent and in check. We actually get a lot of referrals from several HRT clinics for it.

 

[GreenMachineX]

I feel like I don't need to change much as I am already taking a lot of what I saw recommended for this variant. Weirdly I think I fall into the lower dopamine camp as things like stimulants tend to bring me up to baseline. This is definitely something I am going to have to keep digging into and experimenting with.

Your COMT Met Met?

 

[WhatsaBench]

Your COMT Met Met?

Yes, according to the genetic genie results I am +/+ for the first 2 COMT results however I experience low dopamine symptoms far more often then high dopamine symptoms. It could be several things, I see in their notes that my VDR result could lead to low dopamine.

 

[GreenMachineX]

Yes, according to the genetic genie results I am +/+ for the first 2 COMT results however I experience low dopamine symptoms far more often then high dopamine symptoms. It could be several things, I see in their notes that my VDR result could lead to low dopamine.

Oh ok. For years, I had low dopamine symptoms, unsure why, but now I'm over the top all the time.

 

[bell1986]

Yes, according to the genetic genie results I am +/+ for the first 2 COMT results however I experience low dopamine symptoms far more often then high dopamine symptoms. It could be several things, I see in their notes that my VDR result could lead to low dopamine.

Low dopamine?

Have you ever been on an SSRI?

Foolishly I accepted an SSRI years ago when I had zero clue about medications. I was battling horrid anxiety and the doctor says.. This will help your anxiety. Prozac. I mind about 6 months into it and just feeling like a robot that I knew this drug was wrong. I was tired 24/7. I couldn't ejaculate... I mean once a month was a chore. No joke. I quit it cold turkey. God I felt horrendous for over a month. I had anhedonia beyond belief.

Until this day.. That drug has honestly f*cked me up. I feel much better now but I still can tell I'm not the same as prior. I went to that doctor and let rip to her. She says.. Yes side effects are very common on this medication. Do you want some viagra? Lol.. I says.. Unless I'm dying I will never touch a medication again (Prescribed). I went crazy learning about drugs etc and filled my brain with knowledge. I used Selegiline to raise my dopamine back up and used 9-mbc to repair my dopamine system and it worked but I still ain't as good as prior.

I hope you aren't on an SSRI. I genuinely think their dreadful drugs. High Serotonin just makes us so Emotionless and numb. You want higher dopamine if anything.

Good luck

 

[WhatsaBench]

Low dopamine?

Have you ever been on an SSRI?

Foolishly I accepted an SSRI years ago when I had zero clue about medications. I was battling horrid anxiety and the doctor says.. This will help your anxiety. Prozac. I mind about 6 months into it and just feeling like a robot that I knew this drug was wrong. I was tired 24/7. I couldn't ejaculate... I mean once a month was a chore. No joke. I quit it cold turkey. God I felt horrendous for over a month. I had anhedonia beyond belief.

Until this day.. That drug has honestly f*cked me up. I feel much better now but I still can tell I'm not the same as prior. I went to that doctor and let rip to her. She says.. Yes side effects are very common on this medication. Do you want some viagra? Lol.. I says.. Unless I'm dying I will never touch a medication again (Prescribed). I went crazy learning about drugs etc and filled my brain with knowledge. I used Selegiline to raise my dopamine back up and used 9-mbc to repair my dopamine system and it worked but I still ain't as good as prior.

I hope you aren't on an SSRI. I genuinely think their dreadful drugs. High Serotonin just makes us so Emotionless and numb. You want higher dopamine if anything.

Good luck

Nope never been on an SSRI I have my own distrust of prescription meds especially if they just want you to stay on it for life. It is possible I might have high serontonin naturally who knows, I also saw that one of my VDR receptor results can result in lower than normal dopamine.