Examine doesn't mention this, but celastrol, a triterpene in the extract, may be an effective anti-androgen. It rather potently destabilizes the HSP90 chaperone protein, which ultimately leads to the destabilization and degradation of androgen receptor proteins. HSP90 is also important to the function of other nuclear receptors and cellular signalling processes, so this effect is not AR-specific.
"As a HSP90 inhibitor, celastrol decreases many HSP90 client proteins including Akt, Cdk4, FLT3, EGFR, BCR-ABL and androgen receptor (AR), but the mechanisms underlying remain largely unknown."
(From "The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine", doi: 10.3390/molecules16065283)
There are more details at:
-"Celastrol Inhibits Hsp90 Chaperoning of Steroid Receptors by Inducing Fibrillization of the Co-chaperone p23", doi: 10.1074/jbc.M109.081018
-"Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators" doi: 10.1016/j.ccr.2006.09.005
There are, additionally, many other papers on this subject. The bottom-line, I suppose, is that celastrol may be interesting as a chemotherapeutic lead compound, but I certainly wouldn't supplement with it -- or any extract that contains meaningful levels of it.