Anybody know of a natty supp that will inhibit cck? want to try and find something I can use to reduce/reverse drug tolerances. I only know of proglumide but I cannot locate a source for it. any help appreciated.
Last edited:
yes cholecystokinin. I want to reverse or try to lower my tolerance to kratom. apparently cck is what causes a tolerance to build after taking certain types of drugs, like opioids.Just to clarify before i can answer your question more specifically, are you referring to cholecystokinin (peptide related to the Gastrin family) that regulates multiple pathways in digestion and endocrine system?
I'd take a break, and then from there dose your kratom with agmatine. Agmatine is supposed to reduce/prevent tollerance and potentiate opiates.yes cholecystokinin. I want to reverse or try to lower my tolerance to kratom. apparently cck is what causes a tolerance to build after taking certain types of drugs, like opioids.
Yeah I think I remember reading that one somewhere also. There are a few meds being studied now for lowering tolerance to opioids specifically. I’ll have to go looking for those studies again.I'd take a break, and then from there dose your kratom with agmatine. Agmatine is supposed to reduce/prevent tollerance and potentiate opiates.
I don't have the research to support this, but a Google search should provide it pretty easily.
Please explain the use of these chelated vitamins a little more in depth.I think your best bet besides the obvious of taking time off is to use high doses of chelated magnesium daily. Also chelated zinc. Both can serve as nmda antagonists. Zinc also helps through its own specific pathway. Also memantine may be worth a try, though that may be hard to acquire.
The chelated aspect is purely to increase bioavailability and decreases GI side effects. You could take non chelated magnesium and zinc but it’s suboptimal in comparison. But besides bioavailability some chelated products can more readily cross the blood brain barrier (more on that below). Magnesium acts as an nmda antagonist in the CNS, zinc does this as well but to a lesser degree, and usually only when cns magnesium levels are low. As far as the mechanism by which nmda antagonism is beneficial to tolerance of opiates and amphetamines, the long answer can be found by searching “nmda antagonism tolerance opiates amphetamines” (or something along those lines).. the short answer is that antagonizing these receptors causes an acute decrease in signaling, which subsequently leads to an up-regulation of these receptors (likely through both transcription and induction from storage vesicles intracellularly). The increase number of nmda receptors lead to increased signaling over what was present before the antagonism (antagonism does not always do this, sometimes it simply down-regulates the receptor like is the case with SSRIs and 5ht-2a, so we need in vitro experiments to figure out how the receptors respond). Chronic pain and opiate use is linked to downregulation and sensitization of these receptors (the antagonism not only increases the number of receptors but also allows for less chronic and morePlease explain the use of these chelated vitamins a little more in depth.
No problem man. I get carried away sometimes lol. But in all seriousness whenever someone tries to grill you and ask for explicit evidence for something beyond just musing and surmising, the go to answer (and one I use a lot) is “hmm... well...more research is needed!” LolWow, that was way more helpful, and an in-depth answer than I could ask for. Thanks man. Definitely interesting.
I never said I have an issue and need to taper off. my dose has been very low thus far. just want to make the use of it more enjoyable. there are several potentiates to do this but I've not seen anything that will reduce or reverse tolerance such as proglumide is supposed to, hence my search for a natty cck inhibitor.The best option is to taper off and take some time away. The fact that you have such an issue should be a clue that you have been using to much or too long.
I have no personal experience with dosing the compound. But from what I’ve read lower doses are more stimulant like whereas higher doses have more opiate properties. Maybe your dose is not high enough? Just a thought.I never said I have an issue and need to taper off. my dose has been very low thus far. just want to make the use of it more enjoyable. there are several potentiates to do this but I've not seen anything that will reduce or reverse tolerance such as proglumide is supposed to, hence my search for a natty cck inhibitor.
thanks for your responses, wasn't sure what you meant by "dirty" but it makes sense now. yeah my dose is very low, probably need to increase it or just back off for a while. I have had trouble in the past with using too much kratom and had some pretty severe withdrawals so I learned my lesson back then and now I pay close attention to how much I use and when to back off. never knew zinc affected nmda receptors, interesting stuff.And also I’m sorry to tell you what you probably already realize... the medications we have that target the CCK pathway are extremely limited. And even the ones that we do have are somewhat dirty meaning they don’t just do what you want them to do. Maybe in 20 years... It takes at least 10 years for a drug from development to even make it to approval. And if we don’t have big pharm companies doing the biochemical studies to see if the drug can actually influence that pathway (and then the human data to show that it can even make it to the brain and do all that), we are really just shooting randomly in the night, at best, trying to find something that fits the bill. But if you end up getting and trying the one drug you mentioned please let us know if it helps.
Thread starter | Similar threads | Forum | Replies | Date |
---|---|---|---|---|
somatostatin inhibitors | Supplements | 0 | ||
Save 10% On Our Highest Ranking Myostatin Inhibitor! | Company Promotions | 1 | ||
Save 10% On This Powerful Myostatin Inhibitor By CEL | Company Promotions | 3 | ||
Ghoossst is bacckkk!!! Share your first experiences? | Anabolics | 11 | ||
I'm Baaaccckkkk | General Chat | 8 |