supplements are not the go-to here, the wrist needs to be at 30 degrees to alleviate the pressure on the median nerve. It is more physical than it is a scenario of why supplements would help. Get a wrist brace, any wrist brace, that puts the writs ina 30 degrees position, preferably overnight, which will give it multiple hours in the position, and it will heal. If surgery s needed, then it may not cure it, but it will do head and shoulders more than supps will. The source is my dad who suffered from it for 3 decades ad tried every supp, before fixing it with manual positioning