Studies have shown that it improves glucose disposal and insulin sensitivity, so it certainly is possible...especially in a fasted state.
I had a difficult time with this when I first started using Cardarine years ago. It gave me incredible endurance during cardio, but left me very lethargic throughout the day otherwise. My body did adjust to it over time though and it wasn’t as problematic.
Start in the 5-10mg range and work your way up from there as desired and tolerated. I wouldn’t go above 20mg per day though. Personally, I have never gone over 15mg and usually keep it at just 10mg.