GHRP regards the pituitary, tells it to release more HGH, if your prone to diabetes i hear this will speed it up ( prone meaning genetic)
IGF will mess with your sensitivty,can be bad in high doses,it doenst bind to your IR like REAL insulin would, but i doubt youll be going over sat. doses, in which case no, if your running these at there below sat. dose for a GOOD amount of time, you will not encounter problems unless your genetically prone to diseases that are going to mess with your blood glucose levels.