Ask a biochemist anything! Part Deux: The Androgen Receptor

McBain83 said:
Not sure if this is outside the scope of this thread, but here goes:

Several studies indicate that lactate is an effective test-booster, i.e. more testosterone and increased LH. However, in one study, the most advanced athletes had the highest LH-effect of lactate, but their test actually decreased. It also appears to me that advanced athletes may have more androgen reseptors as a result of their training.

Now: Does androgen receptors "suck" free test out of the bloodstream, therefore reducing the amount available? Or is it affecting the androngen receptor when in unbound (free) state?

Lets say athlete A has a free T-level of 5, boosting it to 7 short term due to lactate.
Athlete B also has a free T-level of 5, boosting it to 6 short term due to lactate.

Athlete A has more androgen receptors, sucking more of his free test out of the bloodstream. He ends up with a free test of 4, while athlete B has fewer receptors and is still at 5. However, athlete A has a larger effect in practice, as there is more testosterone bound to the androgen receptor.

Hope you understand my clumsily constructed question :)

Don't mind the values themselves, examples only. We also use different units for blood work here in Norway, which might make the values seem odd.
Click to expand...

Interesting. I would think the type of training to produce significant amounts of lactate would mirror that of high intensity aerobic intervals...and we know that aerobic training results in a chronic/resting decrease in T and increase in cort.

Br
 
ZiR RED said:
Interesting. I would think the type of training to produce significant amounts of lactate would mirror that of high intensity aerobic intervals...and we know that aerobic training results in a chronic/resting decrease in T and increase in cort.

Br
Click to expand...

As far as my research goes, the shorter the effort the better, given that one has reached a certain level of lactate. About 10 seems to be ideal.

I do this by running at an 15% incline for 45 secs, flip tires like a mad man or something equivalent before and after sessions.

ergo-log.com/lactatetest.html
 
This article/study has statements that are inline with my theory of androgen receptors sucking testosterone from the bloodstream. :D

ergo-log.com/traintest.html
 
Hey Professor. Me again.

I had a question about stacking, as in taking multiple anabolic steroid compounds simultaneously. The intent is to induce some form of pharmacological synergy (for those reading this who don't know what I mean it's like 2+2=5 instead of just 4 . Or the whole is greater than the sum of its parts, for example). I know for certain that some drug combinations will produce a synergistic effect. These situations usually work by the two different compounds activating distinct receptors that are biochemically linked downstream to amplify each other. For example, CJC-1295 and GHRP work together this way to cause excretion of Growth Hormone. CJC works on the GHRH receptor, and GHRP works on the Ghrelin receptor. Both induce GH release, but when both are taken together, even more GH is released than expected than adding together what each one would do on its own.

Anyway, I'm wondering if there is any support for the traditional practice of stacking anabolic steroids to produce a synergistic, instead of just additive, effect. I'm confused since these compounds all compete for the same testosterone receptor instead of working on separate, yet interconnected pathways. Have you come across anything in your research that would either offer proof that there is a synergistic benefit of stacking steroids or a hypothesis about what could make them synergistic? Or is there no synergy?

There are several benefits about stacking compounds, but it's not because of synergy. Here are some examples.
1. If taking a non-aromatizing steroid (trenbolone for example), mixing in an aromatizing steroid (e.g. testosterone) would allow some conversion to estrogen. This would provide sufficient estrogen to maintain health and sex drive. Maintenance estrogen might also benefit anabolic growth in some way as well, although I don't know.
2. Mixing a powerful oral (high anabolic potency, quick gains which are lost fast, hepatoxic so must be done short term) with an injectable (longer term possible due to minimal hepatoxicity) would help to solidify and maintain gains made from the oral compound.

I understand the logic behind these stacks, but they still don't offer an example of true synergism as is claimed for stacks. They're more just similar compounds each with salient features that are good blended together.

Anyway, I know you haven't checked this thread in a while, but I figured I'd ask. Thanks prof. And anyone is free to offer their ideas of course.
 
If I wasn't on my phone, I would respond to this, but if you want a detailed answer, you should ask it in the patrick arnold technical q/a section
 
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