Not necessarily.
If you are running 300-1000mg/wk, perhaps you'll see an increase. But this is completely controllable if it's just test alone. The synthetics are much worse though and pretty much any oral outside of Anavar and Stanodrol are going to trash the profile. Another thing to consider is that test has a less negative affect on HDL and LDL ratios, but may increase the total amount. H-drol on the other hand, killed my HDL and slightly raised my LDL, which is good enough reason to keep cycles to a 6 week maximum.
Every one is a little different so you'd need to do a before and after blood test to actually know for sure.