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Article: Rauwolscine or Yohimbine?

I didn't read this article, but I'm about 10000% sure it is BS saying Rawolscine is not yohimbine and better...when its not technically. Rauwoiscine is exactly alpha-yohimbine, and alpha-yohimbine is so close to yohimbine base that it looks the same for the most part chemically.

Also there are some misconceptions....#1 There are no Rowfolia trees being extracted for Rauwolscine. Rauwolscine is being used in damn near every preworkout on earth now, where are all these Rauwolfiatrees coming from and who is doing the extraction?

This is how you get Rauwolfia standardized for 90% Rauwolscine.....You take like 90g of alpha-yohimbine HCL ...Add 10g of some tree bark, even Rauwolfia bark. .....now all of a sudden you got a 100g of 90% extract of Rauwiscine....BS.

No one really uses Yohimbe standardized for over 8% Yohimbine base because to standardize yohimbe for 90% yohimbine would put the extract at a ridiculously high price. So what that said, same goes for Rauwolfia, and Quebracho trees. They are the exact same as Yohimbe trees.

I just hate that some consumer will see this stuff that is stim sensitive or cant have yohimbe and goes "oh its yohimbe free." I saw a company on AM straight up tell a consumer there Rauwolscine product was "yohimbine free" when thats not the case. There is no way rauwolscine is jitter free, because for one if its one bit of the alpha 2-adrenoceptor antagonist yohimbine is, it will increase Catecholamines and an overflow of catecholamines is what causes the jitterness and anxiety in some people.
 
Agreed. Great post.
 
Whacked said:
Agreed. Great post but I think there is a typo. Pretty sure A-yo is an Alpha-1 antagonist (not alpha-2)

Good work man (last paragraph of yours)
Click to expand...

A-yo is an antagonist of alpha 1 and 2. All substrates of yohimbine base bind to alpha 2. Some people believe A-Yo binds to 2 more than yohimbine base, the people at Avant labs use to talk about this over 10 yrs ago, but non-the-less, all this A-yo binds to alpha 1 not 2, its more bro science and it doesn't matter, but alpha 1 and alpha 2 when bound "plugged" by yohimbine (any substrate) will increase noradrenaline and adrenaline. Its just a binding of alpha one increase noradrenaline more than adrenaline.

The bigger difference is how they bind to alpha 2a, 2b and 2c. Basically if you take 10mg of a-yohimbine, 12mg of this 90% Rauwolscine, 10mg of Yohimbine HCL, you will not feel any different from one or the other. Its just companies want you to believe there are some Rauwolfia trees being extracted for rauwolscine which is BS. Actually its not companies want you to believe that, they really don't know. I have dealt with manufactures and suppliers who don't even know the difference between yohimbe, yohimbine HCL and yohimbine base...so its not their fault. They just put in there what everyone else is using.

So if you take any sample of anything labels "Rauwfolia" extract, and send it to Chormadex or any high end lab, the analysis will come back with a % of a-yohimbine HCL.


354.44 g/mol - Rauwolscine C21H26N2O3 (from the tree)
354.44 g/mol - Yohimbine base C21H26N2O3 from the tree)

^^^ There is no way one is "jitter free" ^^

Now yohimbine HCL comes in with a higher mass at over 390 which is how you determine if a product has yohimbine base or yohimbine HCL.
99% of anything sold as "yohimbe bark extract standardized for yohimbine HCL" is technically wrong, you cant standardize yohimbe bark for yohimbine HCL and its just yohimbe with yohimbine HCL added.....same with Rauwfolia. To test this you have to perform a test for alpha-yohimbine HCL.
 
Good stuff Chuck!
 
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