I'm comfortable at 12.5mg EOD. Started at 6.25mg EOD and then experimented with 12.5. Didnt crash estrogen. Feeling good. Compared to Arimidex, Aromasin feels "cleaner". Was taking .25mg of Arimidex EOD. Arimidex feels stronger, but I would crash my E2 much easier. So yeah, lovin' Aromasin