Forgive my ignorance about this as I don't know a lot of the science behind these things, but I am curious as to how much of topical supplements become systemic throughout our body. For instance fat burners, I understand Evomuse Supernova/Hypernova is supposed to stay localized, but what keeps it that way? I've read that Vasoburn acts in a systemic way and affects the whole central nervous system. I'm just trying to wrap my head around all of this. I would like to apply a topical fat burner that is localized only if that's at all possible.