Arachidonic Acid

angelo212

Member
Can any biology or chemistry people break this down?

Arachidonic acid metabolites follow the preferential course of cyclooxygenase pathway for the basal tone in the internal anal sphincter
Márcio A. F. de Godoy, Neeru Rattan, and Satish Rattan
Department of Medicine, Division of Gastroenterology and Hepatology, and Department of Anesthesiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania

Submitted 18 December 2008 ; accepted in final form 7 February 2009


Present studies determined the roles of the cyclooxygenase (COX) versus the lipoxygenase (LO) pathways in the metabolic pathway of arachidonic acid (AA) in the internal anal sphincter (IAS) tone. Studies were performed in the rat IAS versus the nontonic rectal smooth muscle (RSM). Indomethacin, the dual COX inhibitor, but not nordihydroguaiaretic acid (NDGA), the LO inhibitor, produced a precipitous decrease in the IAS tone. However, when added in the background of indomethacin, NDGA caused significant reversal of the IAS tone. These inhibitors had no significant effect on the RSM. To follow the significance of COX versus LO pathways, we examined the effects of AA and its metabolites. In the IAS, AA caused an increase in the IAS tone (Emax = 38.8 ± 3.0% and pEC50 = 3.4 ± 0.1). In the RSM, AA was significantly less efficacious and potent (Emax = 11.3 ± 3.5% and pEC50 = 2.2 ± 0.3). The AA metabolites (via COXs) PGF2 and U-46619 (a stable analog of thromboxane A2) produced increases in the IAS tone and force in the RSM. Conversely, AA metabolites (via 5-LO) lipoxin A4, 5-HETE, and leukotriene C4 decreased the IAS tone. Finally, the contractile effects of AA in the IAS were selectively attenuated by the COX-1 but not the COX-2 inhibitor. Collectively, the specific effects of AA and the COX inhibitor, the Western blot and RT-PCR analyses showing specifically higher levels of COX-1, suggest a preferential role of the COX (specifically COX-1) pathway versus the LO in the regulation of the IAS tone.


smooth muscle tone; thromboxanes; prostaglandin F2



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i don't understand why you want to know it,
basically the study state that the metabolic pathway of AA responsable of IAS tone was the COX mediated pathway.
we know that COX produce PGx from AA and LO (2 class of enzymes) produces lipoxine and other substance like leukotriene.
in the contraction of this Sphincter Pg (produces by cox 1) increase the tone, while lipoxin and leukotriene and cox 1 inhibitor show a decrease in the tone of this sphincter.
but i don't see the importance in the SPort or BB world
 
Quote:
Clinically tested at Baylor University for safety and effectiveness, is the world's first patented hypertrophic catalyst. By enhancing the storage of arachidonic acid in exercised muscles, it drastically amplifies the body's sensitivity and responsiveness to resistance training. This means faster and more profound increases in muscle size, strength, even the rate of lipolysis (fat loss). Clinical trials at the Exercise & Sport Nutrition Lab at Baylor University have demonstrated remarkable increases in muscle strength (44% > placebo), peak muscle power (600% > placebo), average power (223% > placebo), and anaerobic endurance (250% > placebo) with 50 days of Arachidonic Acid supplementation. Having passed the ultimate test of clinical investigation and peer-review, Arachidoinic Acid joins the elite ranks of a select few clinically proven ergogenic agents.
 
what's the difference between the supplementation form, and the increase by diet (eggs, wustel, fat fish and so on?).
with 3 eggs, 100 gr of wustel, 100 gr of fish (sardine) and 200 gr of meat you can eat approx 2 gr of AA. while the supplementation form is very expensive
 
homer said:
i don't understand why you want to know it,
basically the study state that the metabolic pathway of AA responsable of IAS tone was the COX mediated pathway.
we know that COX produce PGx from AA and LO (2 class of enzymes) produces lipoxine and other substance like leukotriene.
in the contraction of this Sphincter Pg (produces by cox 1) increase the tone, while lipoxin and leukotriene and cox 1 inhibitor show a decrease in the tone of this sphincter.
but i don't see the importance in the SPort or BB world
Click to expand...

That's why I asked. I wanted to know if it had any significance to weightlifters.
 
this study explore other things. but i think yes, generally it can help to put same strenght and mass...
 
Careful with this! Arachidonic Acid Is GREAT for Fat loss an muscle building of this i can attest personally, But it's a B I T C H on the joints. Pro inflamatory
 
Cycled it and didn't get much off it either. Strength jumped a bit during the third week then the gains were no better than usual. Not worth the price IMO.
 
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