Depends on your goals. Assuming you're talking about epistane, I'm on my first cycle of it and I haven't experienced a whole lot in terms of negative sides, and it's well known to be relatively safe in moderate doses.
Trestolone however I would not reccomend whatsoever for a first time user. Get some experience under your belt first.
1andro and 4 andro seem to be very safe options but I feel like comparing the two to epistane is like apples and oranges.
Bulking up I'd go: 1/4/epiandro
Cutting: epistane (that's what I'm running for contest prep)
Also make sure for the love of god you have the correct pct lined up and necessary on cycle supports!