AMPk and Hypertrophy

Avengeme

Avengeme

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Is it correct that ampk interferes with muscle growth? Should ampk activating supplements be taken as far from exercise as possible?
 
aaronuconn

aaronuconn

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People tend to get to caught up in the details in regards to AMPk and hypertrophy. AMPk will suppress mTOR, but will it be completely demoralizing towards gaining muscle? I think not, especially in the context of a high protein diet
 

Rockzilla

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https://www.ncbi.nlm.nih.gov/m/pubmed/24408998/

AMPk does not effect hypertrophy. But it does effect power output.

So you can pick either muscle size and elevated cardiac capacity and health and other benefits from AMPk, longevity etc. or you can pick muscle size AND strength/power.
 
muscleupcrohn

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https://www.ncbi.nlm.nih.gov/m/pubmed/24408998/

AMPk does not effect hypertrophy. But it does effect power output.

So you can pick either muscle size and elevated cardiac capacity and health and other benefits from AMPk, longevity etc. or you can pick muscle size AND strength/power.
Solid study. From the full text:
The current study scrutinized the proposed negative effect of
AE-induced AMPK activation on subsequent muscle signaling
and hypertrophic responses to RE training. Our novel results
show that AMPK activation prompted by AE does not compromise
hypertrophy in human muscle subjected to RE. Indeed,
concurrent AE  RE rather produced greater increase in
muscle size than RE.
Is it possible that increases in strength weren't noted because the methodology of the training/testing protocol involved performing resistance exercise after aerobic exercise; that is every time "lifting" was performed, it was after already doing aerobic exercise. Is it possible that this could have in some way hindered strength progression but not interfered with hypertrophy, or perhaps even augmented it? Could it be that the acute glycogen depletion the aerobic exercise caused (this was observed in the study) lead to reduced strength progression but didn't interfere with hypertrophy. There may be other pathways/etc. in which performing aerobic exercise directly before lifting could hinder strength progression, but perhaps these negative effects could be mitigated by performing aerobic exercise after resistance exercise, further separated in time from the resistance exercise, or even on a different day than the resistance exercise? Maybe, maybe not, just thinking out loud at this point.
 

Rockzilla

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You have a good point simple glycogen depletion and possible lactic acid coulda prevented strength gain.

This could also shine light on how limited signaling different pathways for muscle growth is. AMPk stops MTOR signaling yet hypertrophy was made equal due to AR and RE reducing myostatin. It could mean 2 things, either our body makes up the Hypertrophy from reduced MTOR by reducing myostatin even more from exercise, or MTOR doesn’t have the effect on hypertrophy we thought it did.
 

Rockzilla

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https://www.google.com/amp/s/www.researchgate.net/publication/6913855_Resistance_exercise_increases_AMPK_activity_and_reduces_4E-BP1_phosphorylation_and_protein_synthesis_in_human_skeletal_muscle/amp

I don’t even know if that link will work, but this says AMPK was elevated immediately post and 1 hour after Resistance exercise. However, by 1-2 h post-exercise, muscle protein synthesis increased in association with an activation of protein kinase B, mTOR, S6K1 and eEF2.

So it looks like even with resistance training and even up to 1hr post, your body is looking to use/refuel it’s carb stores. Rather than trying to signal it’s anabolic growth factors.
 

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