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BAIBA: A new weight loss supplement that might actually work?
Writeup source - BAIBA - Molecular Gainz
Within the past decade some very exciting research has emerged outlining the effects of a compound known as Beta-Aminoisobutyric Acid (BAIBA). This molecule is derived from the break down of two amino acids thymine and valine and acts on the body in many different ways. Most well known for its potential to combat obesity and diabetes, BAIBA also has practical applications for bodybuilders, athletes, and fitness enthusiasts alike. This article will serve as an overview explaining and drawing conclusions from the latest research involving BAIBA.
To make sense of the benefits of BAIBA one must understand the difference between white and brown fat. The human body stores fat in two primary ways: as either white adipose tissue (WAT) or brown adipose tissue (BAT). White fat is more for long-term storage and accumulates when the human body has excess triglycerides . Brown fat on the other hand is a much more active fat store that is specialized to transfer the potential energy from food into heat . Recent research suggests that it is possible to “brown” white fat tissue and this occurs through exercise and BAIBA supplementation [3,4]. Uncoupling protein-1 (UCP-1) and cell death-inducing DFFA-like effector a (CIDEA) are two brown fat-specific genes that exert increased expression in white fat. UCP-1 plays a major role in the thermogenic effects of BAT, and CIDEA regulates thermogenesis .
In a study published last year researchers set out to determine whether or not BAIBA supplementation in mice could increase
the expression of the genes listed above in WAT. At a dose of 100 mg/kg/day there was an 8.8-fold increase in UCP-1 expression and a 12.1-fold increase at a dose of 170 mg/kg/day. CIDEA expression was increased by 3.4-fold and 5.24-fold from the 100 and 170 mg/kg/day doses. This study also found that BAIBA supplementation increased peroxisome proliferator-activated receptor-gamma coactivator-1a (PGC-1a) by 1.3-fold in the 100 mg/kg/day group and 2.6-fold in the 170 mg/kg/day group . PGC-1a is regulator of metabolic genes in skeletal muscle and also regulates the creation of mitochondria, which are the energy-producing powerhouses in cells .
Another very important finding from this study was that BAIBA increased peroxisome proliferator-activated receptor a (PPARa) by 2.2-fold . This is a huge finding because PPARa plays a major role in energy homeostasis and is a primary regulator of fat metabolism. PPARa has an elevated expression in numerous organs that have high fatty acid break down including the liver, heart, kidneys, BAT, and intestine . There is an overwhelming amount of research regarding PPARa but here’s an overview of many of the notable roles that PPARa has in the body:
PPARa stimulates the expression of UCP-1, which as mentioned above, plays a role in the thermogenic effect of BAT .
Fat metabolism is mainly regulated by the liver where fatty acids are being metabolized inorder to provide peripheral tissues with a constant supply of energy. Scientists have determined that many of the processes that underlie fat metabolism in the liver such as fatty acid activation, transportation, and uptake through cell membranes, are all controlled by PPARa .
It is also clear that PPARa controls just about every enzymatic step involved in the fatty acid oxidative process .
PPARa upregulates many of the transport proteins that carry fatty acids across cell membranes before they can be metabolized by the liver 
Activation of PPARa reduces the amount of triglycerides in the blood .
PPARa also exerts anti-inflammatory roles in the body. It does so by interfering with numerous pro-inflammatory proteins and inhibiting their signaling [8, 11].
This study shows that BAIBA administration has the potential to affect fat loss through various mechanisms. It primarily does so by activating specific genes that control the utilization of fats for energy in WAT. Most notably it increases PPARa, which has a very strong influence in WAT. This is beneficial because it basically turns on long-term fat stores so that they exert BAT characteristics by increasing thermogenesis. This is a phenomenon seen during exercise but this study demonstrates how BAIBA supplementation can produce the same effect.
Another important study done by Begriche et al.  looked at the effects BAIBA had on mice with diet-induced obesity. The groups in this study consisted of one with full leptin deficiency, partial leptin deficiency, and one with normal leptin levels. Each group was fed 100 mg/kg/day of BAIBA. Leptin is a very important fat burning hormone that regulates feelings of satiety and metabolism . The mice involved were fed a high calorie diet and these experiments produced some pretty cool results. BAIBA supplementation was able to almost entirely prevent the gain of fat in the mice with partial leptin deficiency . Throughout the 4 month duration of this trial it was also determined that fat mass was reduced by 40%. Favorable results were found primarily in the group with partial leptin deficiency, which suggested that BAIBA is dependent on leptin. It was also discovered that BAIBA was able to prevent diet-induced obesity by restoring leptin production and increasing its secretion by adipose tissue .
These findings suggest that BAIBA can be very beneficial for body builders, especially those coming off a contest prep diet. It’s clear that low-calorie diets can decrease leptin production [14,15] and BAIBA supplementation can potentially restore leptin levels as well as prevent the initial fat gain that many competitors experience known as the “post show rebound.” These results also make BAIBA supplementation plausible when one is eating in a hypercaloric state due to its possible role in preventing fat accumulation.
The studies presented above clearly demonstrate the various physiological roles BAIBA has. The studies I have presented were all conducted on mice and in vitro so the question remains: is BAIBA an effective supplement for fat loss and the prevention of fat accumulation in humans? Unfortunately at this time we are lacking conclusive evidence to draw those conclusions. However, given the current body of research that has been able to produce consistent results, I will say that BAIBA producing favorable effects in humans seems extremely probable. To have such profound effects in mice would lead one to believe that these effects could be reproduced in humans but possibly to a smaller degree. As far as dosages of BAIBA, it seems that 100 mg/kg/day was consistently used throughout various experiments. This would equate to about 600 milligrams a day for an average person based off the human equivalent dose. To my knowledge no adequate clinical doses for humans are known at this time so one would have to experiment but most users have reported noticeable results with doses ranging from 500mg - 1000mg a day. To try this supplement I would recommend looking into Anteaus Labs BAIBA from SoCal Nutrition. It's a pure BAIBA supplement that is very reasonably priced.
1. Saely, Christoph, Kathrin Geiger, and Heinz Drexel. "Brown versus White Adipose Tissue: A Mini-Review." Gerontology. December 7, 2010. Accessed September ` 12, 2015.
2. Cannon, Barbara, and Jan NEDERGAARD. "Brown Adipose Tissue: Function and Physiological Significance." Physiological Reviews. 2004. Accessed September 12, 2015.
3. Cao, L., Choi, E.Y., Liu, X., Martin, A., Wang, C., Xu, X., and During, M.J. (2011). White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab. 14, 324-338
4. Roberts, Lee D. et al. "B-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic B-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors." Cell metabolism 19.1 (2014): 96-108. PMC. Web. 12 Sept. 2015.
5. Ginter, E, and V Simko. "Recent Data On Obesity Research: Β-Aminoisobutyric Acid." Bratislavské Lekárske Listy 115.8 (2014): 492-493. MEDLINE. Web. 12 Sept. 2015.
6. Boström, Pontus et al. “A PGC1α-Dependent Myokine That Drives Browning of White Fat and Thermogenesis.” Nature 481.7382 (2012): 463–468. PMC. Web. 12 Sept. 2015.
7. Hellemans K., Michalik L., Dittie A., Knorr A., Rombouts K., De Jong J. et al. (2003) Peroxisome proliferator-activated re-ceptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Gastroenterology 124: 184 – 201
8. Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, and Sander Kersten, “Peroxisome Proliferator-Activated Receptor Alpha Target Genes,” PPAR Research, vol. 2010, Article ID 612089, 20 pages, 2010. doi:10.1155/2010/612089
9. Hashimoto T., Fujita T., Usuda N., Cook W., Qi C., Peters J. M. et al. (1999) Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. J. Biol. Chem. 274:19228 – 19236
10. Watanabe K., Fujii H., Takahashi T., Kodama M., Aizawa Y., Ohta Y. et al. (2000) Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J. Biol. Chem. 275: 22293–22299
11. Barbier O., Villeneuve L., Bocher V., Fontaine C., PinedaTorra I., Duhem C. et al. (2003) The UDP-glucuronosyl-transferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J. Biol. Chem. 278: 13975–13983
12. Friedman, Jeffrey. "20 Years Of Leptin: Leptin At 20: An Overview." The Journal Of Endocrinology 223.1 (2014): T1-T8.MEDLINE. Web. 17 Sept. 2015.
14. Jéquier, Eric. "Leptin Signaling, Adiposity, And Energy Balance." Annals Of The New York Academy Of Sciences 967.(2002): 379-388. MEDLINE. Web. 17 Sept. 2015.
15. Anderlová, K, et al. "The Influence Of Very-Low-Calorie-Diet On Serum Leptin, Soluble Leptin Receptor, Adiponectin And Resistin Levels In Obese Women." Physiological Research / Academia Scientiarum Bohemoslovaca 55.3 (2006): 277-283.MEDLINE. Web. 17 Sept. 2015.
16. Kammoun, Helene L, and Mark A Febbraio. "Come On BAIBA Light My Fire." Cell Metabolism 19.1 (2014): 1-2.MEDLINE. Web. 17 Sept. 2015.
17. Ginter, E, and V Simko. "Recent Data On Obesity Research: Β-Aminoisobutyric Acid." Bratislavské Lekárske Listy 115.8 (2014): 492-493. MEDLINE. Web. 17 Sept. 2015.