Calgary or Dallas for the West. (and I should note that I hate them both)
For the regular season and by talent, Dallas is the best in the West, but Calgary is built for the playoffs, so it should be interesting.
Detroit is severly overrated and is in one of the weakest divisions in the league. Minnesota, while being dead last in the NW division, would be in 3rd if they were in Detroit's division (Central), and that's 13 points ahead of of Columbus, who's currently in 3rd in the Central.
If Detroit plays Edmonton (where they're sitting right now), I would bet Detroit doesn't get past the 1st round. Edmonton is also currently winning the series against Detroit, although the Oilers are sucking lately - they do have the potential to be spoilers. (They were voted 2nd by the players of teams they do not want to play against, 1st going to New Jersey).
Carolina for the East. I wouldn't be surprised if Buffalo somehow pulls an underdog though - they have some good grit.
Ottawa should do well on paper, but Hasek is starting to have problems - I sadly predict they will fold.