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AI vs Estrogen Blocker

bulldogger.spa

New member
I've been doing a lot for reading trying to better understand these compounds we use and why, and I've noticed some articles describe them as different, some say they are the same. Any clarification would be appreciated.
 
AI= Aromatase inhibitor. It prevents the aromatase enzyme from acting on testosterone and turning the test into estrogen.

Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. By inhibiting aromatase they increase Testosterone.

Aromatase inhibitors:

AIs are categorized into two types:

Type 1: Irreversible steroidal inhibitors such as exemestane form a permanent bond with the aromatase enzyme complex.
Type 2: Non-steroidal inhibitors (such as anastrozole, letrozole) inhibit the enzyme by reversible competition.

SERM= Selective Estrogen Receptor Modulator. These chemicals act on your estrogen receptors, not estrogen itself. SERMs prevent estrogen from exerting their cellular effects.

SERMs block estrogen from acting on certain sites in the body, while AIs prevent your body from synthesizing estrogen, two very different actions.
 
from my experience, the term estrogen blocker is generally used in one of two ways:
1) a generic term used by people who don't understand aromatase function
2) the term people use to explain things to people who don't have an understanding of aromatase

but, I think @Esgor explained things pretty well
 
bulldogger.spa said:
I've seen numerous people say to use an AI in PCT, but then most people say you need a SERM. It's a bit confusing.
Click to expand...

A big part of the problem is that people tend to make generalized recommendations for PCT, when what a person needs to do for PCT may depend on what they are doing PCT for/from.
 
bulldogger.spa said:
I've seen numerous people say to use an AI in PCT, but then most people say you need a SERM. It's a bit confusing.
Click to expand...

are you familiar with the HPTA negative feedback loop and how it uses estrogen to manage testosterone production? If not, this is a great place to start to begin understanding how PCT works. it's also helpful in understanding how and why people use AI's to increase natural testosterone production - part of the reason why sustain alpha works so well at increasing natural testosterone production.
 
delsolrob said:
are you familiar with the HPTA negative feedback loop and how it uses estrogen to manage testosterone production? If not, this is a great place to start to begin understanding how PCT works. it's also helpful in understanding how and why people use AI's to increase natural testosterone production - part of the reason why sustain alpha works so well at increasing natural testosterone production.
Click to expand...

Can you share some sources that aren't too complicated. lol
 
Last edited:
Well my work here is done. Jk but in all seriousness Rob and SNS have you covered
 
bumping an old thread with bloodwork on Virtus
Invalid Link Removed

there were a number of users who've posted bloodwork over the years, just need to dig for them.
 
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