jinxie
Well-known member
Got glucosamine/chondroitin, MSM, and cissus and have ingested each. Let's keep nailing it. Also bought a Meshuggah and Korn CD. That's gonna make it easier. Little bro didn't dress in his last football game of the season due to hip flexor issues, so I bought him a rumble roller. So now I'm broke again. Fukk. All necessary things.
Dude, consider curcumin, the Meriva formula. I've tried all of this stuff, and none of it touches Meriva, IMO. Stack it with Bioperine, black pepper, for even better bio-availability. Stuff is the bomb. Take it from the guy with 16 ortho surgeries in 5 years, and some vicious chronic pain as a result of a connective tissue disorder.
I am going to add a study for you here.
J Pain Res. 2013;6:201-5. doi: 10.2147/JPR.S42184. Epub 2013 Mar 8.
Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen.
Di Pierro F, Rapacioli G, Di Maio EA, Appendino G, Franceschi F, Togni S.
Source
Velleja Research.
Abstract
In addition to its anti-inflammatory activity, Meriva(®), a proprietary lecithin formulation of curcumin, has been anecdotally reported to decrease acute pain in patients with various chronic diseases. Given that curcumin can desensitize transient receptor potential A1, a nociceptor seemingly also mediating the analgesic effect of acetaminophen, as well as inhibiting and downregulating the expression of cyclo-oxygenase 2, the selective target of nimesulide, a nonsteroidal anti-inflammatory agent, we carried out a pilot comparative study of the acute pain-relieving properties of these three agents. At a dose of 2 g (corresponding to 400 mg of curcumin), Meriva showed clear analgesic activity, comparable with that of a standard dose (1 g) of acetaminophen, but lower than that of a therapeutic (100 mg) dose of nimesulide. The analgesic activity of lower (1.5 g) doses of Meriva was less satisfactory, and the onset of activity was longer than that of nimesulide for both doses. On the other hand, gastric tolerability was significantly better than that of nimesulide and comparable with that of acetaminophen. Taken together, our results show that the preclinical analgesic properties of curcumin have clinical relevance, at least at a dose of 2 g as the Meriva formulation. While this dose is significantly higher than that used to relieve chronic inflammatory conditions (1-1.2 g/day), its pain-relieving activity could benefit from the general downregulation of the inflammatory response induced by curcumin, considering that the transient receptor potential channel-mediated mechanisms of analgesia are magnified by attenuation of inflammation. In patients on treatment with Meriva, this would also translate into better control of acute pain, providing a rationale for the analgesic properties associated with this curcumin formulation.
KEYWORDS:
Meriva®, acetaminophen, acute pain, curcumin phytosome, nimesulide, tolerability
Panminerva Med. 2010 Jun;52(2 Suppl 1):55-62.
Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis.
Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G.
Source
Irvine3 Labs, Department of Biomedical Sciences, Chieti-Pescara University, Pescara, Italy.
Abstract
AIM:
A proprietary complex of curcumin with soy phosphatidylcholine (Meriva®, Indena SpA) was evaluated in a registry study to define its efficacy in 50 patients with osteoarthritis (OA) at dosages corresponding to 200 mg curcumin per diem.
METHODS:
OA signs/symptoms were evaluated by the WOMAC scores. Mobility was studied by walking performance (treadmill), and inflammatory status was assessed by measurements of C-reactive protein (CRP).
RESULTS:
After three months of treatment, the global WOMAC score decreased by 58% (P<0.05), walking distance in the treadmill test was prolonged from 76 m to 332 m (P<0.05), and CRP levels decreased from 168 +/- 18 to 11.3 +/-. 4.1 mg/L in the subpopulation with high CRP. In comparison, the control group experienced only a modest improvement in these parameters (2% in the WOMAC score, from 82 m to 129 m in the treadmill test, and from 175 +/- 12.3 to 112 +/- 22.2 mg/L in the CRP plasma concentration), while the treatment costs (use of anti-inflammatory drugs, treatment and hospitalization) were reduced significantly in the treatment group.
CONCLUSION:
These results show that Meriva® is clinically effective in the management and treatment of osteoarthritis and suggest that the increased stability and better absorption of curcumin induced by complexation with phospholipids have clinical relevance, setting the stage for larger and more prolonged studies.
PMID: 20657536 [PubMed - indexed for MEDLINE]
Here's a recent one re fish oil, in support of what someone else recommended. I still think the jury is sort of out re fish oil (there have been studies that have called into question some of its benefits), but it seems undeniable that it helps with inflammation/oxidative stress. It's cheap, and worth taking, but in my experience, it doesn't hold a candle to Meriva, which is the bombdiggity IMO, but YMMV.
Int J Sport Nutr Exerc Metab. 2013 Nov 13. [Epub ahead of print]
Fish Oil Supplementation Reduces Markers of Oxidative Stress But Not Muscle Soreness After Eccentric Exercise.
Gray P, Chappell A, Jenkinson AM, Thies F, Gray SR.
Source
Institute of Medical Sciences, University of Aberdeen, United Kingdom.
Abstract
Due to the potential anti-inflammatory properties of fish-derived long chain n-3 fatty acids, it has been suggested that athletes should regularly consume fish oils, although evidence in support of this recommendation is not clear. While fish oils can positively modulate immune function, it remains possible that, due to their high number of double bonds, there may be concurrent increases in lipid peroxidation. The current study aims to investigate the effect of fish oil supplementation on exercise-induced markers of oxidative stress and muscle damage. Twenty males underwent a six week double blind randomised placebo-controlled supplementation trial involving two groups (fish oil or placebo). After supplementation, participants undertook 200 repetitions of eccentric knee contractions. Blood samples were taken pre-supplementation, post-supplementation, immediately, 24, 48 and 72h post-exercise and muscle soreness/maximal voluntary contraction (MVC) assessed. There were no differences in creatine kinase, proteincarbonyls, endogenous DNA damage, muscle soreness or MVC between groups. Plasma thiobarbituric acid reactive substances (TBARS) were lower (P<0.05) at 48 and 72h post exercise and H2O2 stimulated DNA damage was lower (P<0.05) immediately post-exercise in the fish oil, compared with the control group. The current study demonstrates that fish oil supplementation reduces selected markers of oxidative stress after a single bout of eccentric exercise.
PMID: 24225668 [PubMed - as supplied by publisher]
I will note that there is some controversy re taking anti-inflamms post workout, some claiming that the inflammation is a necessary part of muscle building. But I've never noticed it to interfere since I take this stuff chronically. Of course, it could be a matter of the pain reduction > the muscle building detriment. All FWIW, YMMV.