Unanswered 1-testosterone/boldenone affect on kidneys?

[Trepstar]

Does 1-testosterone (boldenone) have a direct effect on structural change (damage) of the kidneys? This 2017 study suggests so. Would like to hear others thoughts on it.

Invalid Link Removed

Evaluation of anabolic steroid induced renal damage with sonography in bodybuilders.

Abstract
BACKGROUND:
The aim of this study was to investigate the effect of anabolic steroids on kidneys in bodybuilders.
METHODS:
Twenty-two bodybuilders were included in the study. Participants were divided into three groups according to the scheme of steroid usage: group 1 (N.=8, intramuscular 500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone for 12 weeks), group 2 (N.=7, intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate for 16 weeks), and group 3 (N.=7, no steroid intake). Blood urea nitrogen (BUN), creatinine (Cr), urine micro-albumin and electrolyte levels were measured. Renal volume, cortical thickness and echogenicity were obtained in ultrasonographic scans.
RESULTS:
Renal volume, cortical thickness, echogenicity and protein intake value were significantly higher in group 2 than group 1 and 3. Plasma levels of BUN and Cr in group 2 were significantly higher than other groups (P˂0.001). Urine microalbumin and electrolyte levels were normal in all groups.
CONCLUSIONS:
The results of this study indicate that high protein intake, steroid usage, particularly the schemes, including boldenone undecylenate increases cortical echogenicity, thickness of renal parenchyma and renal volume in bodybuilders.

 

[Renew1]

Does 1-testosterone (boldenone) have a direct effect on structural change (damage) of the kidneys? This 2017 study suggests so. Would like to hear others thoughts on it.

Invalid Link Removed

Evaluation of anabolic steroid induced renal damage with sonography in bodybuilders.

Abstract
BACKGROUND:
The aim of this study was to investigate the effect of anabolic steroids on kidneys in bodybuilders.
METHODS:
Twenty-two bodybuilders were included in the study. Participants were divided into three groups according to the scheme of steroid usage: group 1 (N.=8, intramuscular 500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone for 12 weeks), group 2 (N.=7, intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate for 16 weeks), and group 3 (N.=7, no steroid intake). Blood urea nitrogen (BUN), creatinine (Cr), urine micro-albumin and electrolyte levels were measured. Renal volume, cortical thickness and echogenicity were obtained in ultrasonographic scans.
RESULTS:
Renal volume, cortical thickness, echogenicity and protein intake value were significantly higher in group 2 than group 1 and 3. Plasma levels of BUN and Cr in group 2 were significantly higher than other groups (P˂0.001). Urine microalbumin and electrolyte levels were normal in all groups.
CONCLUSIONS:
The results of this study indicate that high protein intake, steroid usage, particularly the schemes, including boldenone undecylenate increases cortical echogenicity, thickness of renal parenchyma and renal volume in bodybuilders.

You do know that 1-Test isn't Bold, right?

 

[Trepstar]

You do know that 1-Test isn't Bold, right?

No i didn't know that, going by what wiki says:

Boldenone (developmental code name RU-18761), also known as Δ1-testosterone, is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone.[2][3][4][5][6] Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[2][3][6]

 

[jrock645]

No i didn't know that, going by what wiki says:

Boldenone (developmental code name RU-18761), also known as Δ1-testosterone, is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone.[2][3][4][5][6] Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[2][3][6]

They’re not the same. Wiki can be horribly inaccurate as there’s no real verification process for that website. Bold and 1-T are closely related but not the same.

 

[Renew1]

No i didn't know that, going by what wiki says:

Boldenone (developmental code name RU-18761), also known as Δ1-testosterone, is a naturally occurring anabolic–androgenic steroid (AAS) and the 1(2)-dehydrogenated analogue of testosterone.[2][3][4][5][6] Boldenone itself has never been marketed; as a pharmaceutical drug, it is used as boldenone undecylenate, the undecylenate ester.[2][3][6]

Yep.
Always look for what seem like slight differences (they're not really slight).

1-Testosterone (abbreviated and nicknamed as 1-Testo, 1-T), also known as δ1-dihydrotestosterone (δ1-DHT), as well as dihydroboldenone

 

[Trepstar]

They’re not the same. Wiki can be horribly accurate as there’s no real verification process for that website. Bold and 1-T are closely related but not the same.

Thanks. Whats your thoughts on either Boldenone or 1-testosterone causing structural damage to the kidneys?

 

[StarScream66]

So, I see a lot of problems with that study just looking at the abstract. There was only 22 participants. One group was given "500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone (Dianabol)" and the other group was given "intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate".

So, even if they were having problems, they were stacking multiple steroids at once, including the negative liver impact from the Dianabol. So, it's not just like they were taking boldenone in isolation.

And as @Renew1 mentioned, 1-test is not bolenone, although they are structually similar, 1-test is dihydroboldenone, so it can't convert to estrogen and isn't liver toxic (unless it's methylated and you're taking it orally).

But, the Anabolic Doc on YT just made a great video about this very subject.

[youtube]Invalid Link Removed

 

[Renew1]

Thanks. Whats your thoughts on either Boldenone or 1-testosterone causing structural damage to the kidneys?

I honestly don't have an opinion on it, as I haven't studied that aspect of the 2.

I've ran Bold several times in the past, and don't remember any fluctuations worth mentioning.

 

[Trepstar]

I've used EQ and Tren years ago and about to start a cycle including 1-dhea/1-testostoerone. The reason for getting opinions on this study is because I'd been referred to a urologist recently based on blood results showing creatinine levels slighlty over the upper limit and lower range eGFR which I know is considered common among individuals with higher amounts of muscle mass. However, the Doc did his best fear mongering into treatment that's most likely unnecessary.

 

[Trepstar]

So, I see a lot of problems with that study just looking at the abstract. There was only 22 participants. One group was given "500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone (Dianabol)" and the other group was given "intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate".

So, even if they were having problems, they were stacking multiple steroids at once, including the negative liver impact from the Dianabol. So, it's not just like they were taking boldenone in isolation.

And as @Renew1 mentioned, 1-test is not bolenone, although they are structually similar, 1-test is dihydroboldenone, so it can't convert to estrogen and isn't liver toxic (unless it's methylated and you're taking it orally).

But, the Anabolic Doc on YT just made a great video about this very subject.

[youtube]Invalid Link Removed

Yes I arrived at the study from his other video on a powerlifter experiencing kidney failure. One comment linked to the study on Boldenone and structural kidney changes. I'd assumed 1-dhea/1-testosterone would have the same effects as Boldenone on kidneys.

 

[jrock645]

Thanks. Whats your thoughts on either Boldenone or 1-testosterone causing structural damage to the kidneys?

Im not well informed enough to have a strong opinion. I’ve always heard of bold being very mild other than raising rbc count. People either love or hate 1-T. Besides pip, I’ve read 1-T could potentially cause issues, but the guys here that have ran it haven’t mentioned any issues besides pip.

 

[Renew1]

Yes I arrived at the study from his other video on a powerlifter experiencing kidney failure. One comment linked to the study on Boldenone and structural kidney changes. I'd assumed 1-dhea/1-testosterone would have the same effects as Boldenone on kidneys.

You should try not to make assumptions.
What look like small differences chemically, can mean HUGE real-world differences in effects and sides.

Look closer at the Boldenone (wiki) article. It isn't saying that it is 1-Test.

 

[Renew1]

I've used EQ and Tren years ago and about to start a cycle including 1-dhea/1-testostoerone. The reason for getting opinions on this study is because I'd been referred to a urologist recently based on blood results showing creatinine levels slighlty over the upper limit and lower range eGFR which I know is considered common among individuals with higher amounts of muscle mass. However, the Doc did his best fear mongering into treatment that's most likely unnecessary.

When you say, 1-DHEA/1-Test .... You know that those are 2 differnt compounds, right?

 

[Renew1]

I'm honestly just trying to help here, brother. If you'd rather talk via PM, that's fine.

 

[StarScream66]

Yes I arrived at the study from his other video on a powerlifter experiencing kidney failure. One comment linked to the study on Boldenone and structural kidney changes. I'd assumed 1-dhea/1-testosterone would have the same effects as Boldenone on kidneys.

Are there any other studies that replicate this one?

Btw, Big Cat's old profile on Invalid Link Removed is a good start.

Invalid Link Removed

Also, the Anabolic Doc also did a video on boldenone, so both of these videos are absolutely worth a watch.
[youtube]Invalid Link Removed

 

[Trepstar]

When you say, 1-DHEA/1-Test .... You know that those are 2 differnt compounds, right?

Thanks. I appreciate your insight. I do understand 1-DHEA isn’t 1-test but converts to 1-test through a two step process.

 

[Renew1]

Thanks. I appreciate your insight. I do understand 1-DHEA isn’t 1-test but converts to 1-test through a two step process.

Oh, good.
That's a really weak conversion.

 

[Trepstar]

Are there any other studies that replicate this one?

Btw, Big Cat's old profile on Invalid Link Removed is a good start.

Invalid Link Removed

Also, the Anabolic Doc also did a video on boldenone, so both of these videos are absolutely worth a watch.
[youtube]Invalid Link Removed

Thanks. Read BigCats article, he doesn’t mention side effects in relation to kidneys specifically. The HDL lowering and LDL increasing is something I’ll be monitoring alongside blood pressure. I’d like to know if this effect on blood lipids is unique to boldenone and 1/testosterone (I did read a study on 1-DHEA having the same effect on blood lipids).

 

[Renew1]

Thanks. Read BigCats article, he doesn’t mention side effects in relation to kidneys specifically. The HDL lowering and LDL increasing is something I’ll be monitoring alongside blood pressure. I’d like to know if this effect on blood lipids is unique to boldenone and 1/testosterone (I did read a study on 1-DHEA having the same effect on blood lipids).

That's a very common side of steroids.

 

[StarScream66]

Thanks. Read BigCats article, he doesn’t mention side effects in relation to kidneys specifically. The HDL lowering and LDL increasing is something I’ll be monitoring alongside blood pressure. I’d like to know if this effect on blood lipids is unique to boldenone and 1/testosterone (I did read a study on 1-DHEA having the same effect on blood lipids).

Did you watch the video I posted?

 

[Trepstar]

Did you watch the video I posted?

Yes I did. He said Boldenone does damage the kidneys structurally (FSGS) but doesn’t know why.

He also said Dihydroboldenone has little consequence.

I don’t really trust what this Doctor says as much of it is anecdotal and I get the impression he uses fear and uncertainty to increase his client base.

 

[Trepstar]

After doing a little more reading after being corrected that 1-testosterone is NOT boldenone but in actual fact dihydroboldenone, from what I've read dihydroboldenone is not known to be liver or kidney toxic. Although liver weight is shown to increase while on it.

 

[Matthersby]

BUN and Creatinine increase on every steroid. They are typically high year round for bodybuilders and then go higher on a blast.
We don’t have to look for any new ways steroids are tough on our body, we already have the info: cardiovascular, prostate.
Liver for orals(but your body has this neat thing it does where you feel like absolute dog **** so you stop taking the oral, or physically even swallow it, because your body isn’t enjoying the damage it’s doing, and this happens long before permanent damage occurs. So really it’s just CV and prostate concerns.
Kidneys are off limits for the most part luckily.

 

[Codybenz]

I don’t know of any steroids that directly damage/effect kidneys. However, one of the biggest kidney killers is high blood pressure. Lots of anabolics can Jack your blood pressure up which if too high for too long will damage the kidneys.

According to American Kidney association 25% of all us kidney failure cases is related to high blood pressure.

So steroids may not directly cause kidney damage, but indirectly if you let blood pressure get out of hand.

 

[Matthersby]

I don’t know of any steroids that directly damage/effect kidneys. However, one of the biggest kidney killers is high blood pressure. Lots of anabolics can Jack your blood pressure up which if too high for too long will damage the kidneys.

According to American Kidney association 25% of all us kidney failure cases is related to high blood pressure.

So steroids may not directly cause kidney damage, but indirectly if you let blood pressure get out of hand.

Very true.
But I’ll say this having worked in kidney dialysis for a lot of years.
You either have to be completely clueless, ignoring nosebleeds, ignoring all the signs, ridiculously non compliant with your health, or live in poverty and have no access to healthcare, because the kidney failure patients I’ve known due to hypertension had decades to get the problem in order. It’s something that’s a long term killer, like everything with the cardiovascular system, it’s slow. You’d be doing a lot of gear for a loooonnnngggg ass time before your kidneys would fail due to hypertension. We are talking like 180/90 and up bp’s too. A simple checkup at your doc and he/she would have you on bp meds in an hours time with the kind of bp that will one day take out your kidneys. It happens though.

 

[Chrisbenches]

So, I see a lot of problems with that study just looking at the abstract. There was only 22 participants. One group was given "500 mg testosterone enanthate, intramuscular 400 mg nandrolone decanoate and oral 40 mg methandrostenolone (Dianabol)" and the other group was given "intramuscular 500 mg testosterone enanthate, intramuscular 300 mg nandrolone decanoate and intramuscular 300 mg boldenone undecylenate".

So, even if they were having problems, they were stacking multiple steroids at once, including the negative liver impact from the Dianabol. So, it's not just like they were taking boldenone in isolation.

And as @Renew1 mentioned, 1-test is not bolenone, although they are structually similar, 1-test is dihydroboldenone, so it can't convert to estrogen and isn't liver toxic (unless it's methylated and you're taking it orally).

But, the Anabolic Doc on YT just made a great video about this very subject.

[youtube]Invalid Link Removed

Such a good video, thanks for sharing.

 

[Codybenz]

Very true.
But I’ll say this having worked in kidney dialysis for a lot of years.
You either have to be completely clueless, ignoring nosebleeds, ignoring all the signs, ridiculously non compliant with your health, or live in poverty and have no access to healthcare, because the kidney failure patients I’ve known due to hypertension had decades to get the problem in order. It’s something that’s a long term killer, like everything with the cardiovascular system, it’s slow. You’d be doing a lot of gear for a loooonnnngggg ass time before your kidneys would fail due to hypertension. We are talking like 180/90 and up bp’s too. A simple checkup at your doc and he/she would have you on bp meds in an hours time with the kind of bp that will one day take out your kidneys. It happens though.

No you’re right, and I don’t think anybody is going to go into Kidney failure just from a cycle. I think it’s more of a long term a little damage at a time type thing. Which over the years adds up, on top of decreased kidney function as we age.

All the more reason to keep labs up to date and keep an eye on everything when one chooses to start using anabolics.