1-methly group

[PIOTREK]

this is a quote from big cat's article:

"The low liver-toxicity is accounted for that the bio-availability of methenolone is carried by a 1-methyl-group, which lessens the need for a carrier attachment such as a 17-alpha-akylated group, the main culprit in steroid-related liver afflictions."

my question is, why has this alternate method (1-methly-group modification) not been employed in more drugs/once legal prosteroids?

 

[bigpetefox]

The c17aa attachment seems to make the product stronger.. Proviron is 1-methylated, yet it's merely a weak DHT with high oral availability.. Same with oral Primo, it's 1-methylated, yet it's not highly anabolic..


This is all just my educated guess, though.. Boldenone becomes fast-acting and stronger once it's methylated in the 17th position (methandrostenolone aka Dianabol), so it makes sense..

 

[lifted]

I always thought proviron was 7-alpha alkylated??

 

[bigpetefox]

Mesterolone is 1-methyl-dehydrotestosterone, or Proviron if you're nasty...

1-alpha-methyl-17 betahydroxy-5 alpha-androstan-3one is the longer more geeky name..
Invalid Link Removed

 

[lifted]

proviron cuz I'm a naaaaasty bouy...lol.

 

[Tiftan090]

Why hasn't anyone made 1-methyl boldenone? Would it just have the same estrogenic / androgenic character as dianabol? At least you could take if for a longer amount of time without liver toxicity.