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  1. furion

    Pre cycle bloodwork

    Don't stress about your AST and ALT- it is commonly recognised that in the absence of hepatic injury symptoms elevated alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can be elevated as result of resistance training. In these cases these enzymes are elevated as result of...
  2. furion

    How is estrogen eliminated from the body?

    Put very simply estrogens (there are three main endogenous forms; estradiol- most active, estrone and estriol) are mainly eliminated in urine after undergoing hydroxylation by CYP450 enzymes before being conjugated into water soluble metabolites. Some estrogens are eliminated in faeces as...
  3. furion

    GRHP-2 Thyroid issues? help please

    I would add prolactin to your list. As well as causing secondary hypogonadism there is an association with subclinical hypothyroidism and hyperprolactinemia. Although it's a lot more common in females it's worth testing- especially if you have been using GHRH/GHRPs. I would consider an ACTH...
  4. furion

    Green Coffee Bean Extract - Chlorogenic Acid Burns Fat

    On the topic of chlorogenic acid. There's is some recent data indicating that it has the potential to activate calcineurin in a calmodulin dependant manner- it's has actually been specifically tested in muscle cells and it was found to upregulate myosin heavy chain I mRNA. What this may mean is...
  5. furion

    SNS Rep Search

    Thanks guys. Very much looking forward to working with you. I hope my contributions can be of value to everyone here and with SNS.
  6. furion

    Strange arm feeling

    I would put it down to a simple cramp- nothing to be concerned about at all. The high volume workout had developed a level of muscle fatigue- and what you have described sounds consistent with a theory of exercise induced muscle cramps. In simple terms, at the peripheral muscle receptor the...
  7. furion

    BLOOD WORK analysis

    That's textbook HPTA shutdown- would expect nothing less. When using exogenous testosterone your FSH and LH ARE certainly not a reliable measure of fertility at all. I have seen some very impressive sperm analyses from gentleman on long term TRT and essentially zero gonadotrophins. Get bloods...
  8. furion

    BLOOD WORK analysis

    Don't stress about your liver enzymes in the absence of liver injury symptoms. Your aspartate aminotransferase (SGOT) and alanine aminotransferase (SGPT) can form indiscriminate markers of muscle damage. It is recognised that weight and heavy resistant training can produce false positives of...
  9. furion

    Supplements for kidneys

    As I stated, you have too little information to offer realistic (and safe) recommendations. Additionally, as already noted, a plethora of differentials exist going off the vague symptoms you have described. If diagnosis of an enlarged spleen was only made by palpation (as you described) and...
  10. furion

    Supplements for kidneys

    With what you have described there is too little information to give you a solid recommendation and by the sounds of things it doesn't seem like your doctor has finished diagnostics. How was your splenomegaly diagnosed? The one thing that jumps out for me is the obvious renal involvement given...
  11. furion

    Can someone explain what is a suspension solution / cons ?

    Other way around. Suspension are preparations whereby the actives particles are not dissolved in the vehicle (doesn't necessarily have to be a liquid). A liquid suspension would therefore require shaking to allow even dispersing of the particles (and sometimes need a suspending agent) Solutions...
  12. furion

    Absorption of testosterone. Leg or thigh?

    Using the above medication as reference- the monthly injections do not have the kinetics changed between administration sites after steady state is reached- so it could be inferred that another medication that forms depot and has a shorter half life shouldn't either. I'm assuming the OP has...
  13. furion

    Absorption of testosterone. Leg or thigh?

    I'm not too sure you're going to have much success with that. I can't see the different site making a large enough difference to the kinetics from an already established steady state concentration. It sounds silly that a different site would even vary the kinetics of a depot- however there is...
  14. furion

    Anabolics easy on the BP

    This is a very complex topic with many variables at play. Although estrogen may play a role in the pathogenesis, research hasn't actually specifically implicated it's role in hypertension associated with sex hormones in males. In fact depletion of estrogen is actually associated with reduced...
  15. furion

    Who wants a new BLR SERM?!

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  16. furion

    Who wants a new BLR SERM?!

    This is the most current comprehensive review I have read on the topic. *** I will post it separately to have my post count reach 20 and be capable. Estrogen regulation of inflammatory cytokines seems the most plausible theory in terms of pathogenesis of aromatase inhibitor mediated arthralgia-...
  17. furion

    Possible Antibiotic Reaction To PH?

    I'm not sure there is any specific data on the pharmacokinetics of methylepitiostanol so giving you an answer would be purely theoretical. Clarithromycin is a strong inhibitor of CYP3A4 (phase I liver enzyme) and can cause problems with other substrates when taken together whereby it will...
  18. furion

    Protein Lessons - Brought to you by PEScience

    A Benedict reagent test is sensitive to lactose and could be used to indiscriminately identify low(er) protein/high(er) CHO WPC. It's an easy test to perform and can be done at home. I have seen reagent solution on eBay for around $10. Invalid Link Removed *To state the obvious- substitute...
  19. furion

    Ursolic Acid Reduces Spermatogenesis

    I don't think the skin would express any enzymes that would be active on a highly lipophilic triterpenoid like ursolic acid- so metabolism at the skin level would be unlikely. Lipophilic compounds actually pass through the skin fairly well. I would assume the modification of ursoliic acid to an...
  20. furion

    Who wants a new BLR SERM?!

    In terms of clinical significance (as measured by enough change in therapeutic blood range), neither an anastrazole or letrozole interact with tamoxifen. Although anastrazole and letrozole blood levels are reduced by an average of 27% and 38%, respectively the clinical insignificance of this is...
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