Search results

  1. furion

    Curcumin

    As far as I understand Meriva contains a mixture of curcuminoids of which 75% is curcumin. Although there doesn't appear to be specific evidence indicating distribution to the brain- I would assume that the Meriva would reach measurable brain concentration. Other phosphatidylcholine complexed...
  2. furion

    Tetradecyl Thioacetic Acid (TTA) FAQ

    After 4-5 half lives or 2-3 days (at a BD dose) you should reach a steady state concentration- irrespective of if its taken with or without food.
  3. furion

    Growth Factor XT + Doxylamine Succinate

    There's no reason why they can't be taken together. Doxylamine primarily works as a sedative through antagonism of histamine-1 and acetylcholine receptors- which are not targets of any of the component of GFXT. I would start @ 12.5mg 3/7 and titrate up if necessary. Any more than 25mg 4/7 and I...
  4. furion

    Dangers of ARA

    I responded to a similar question to this a while back: Different arachidonic acid metabolites can act as both bronchodilators (PGe2 PGi2) and bronchoconstrictors (PGd2 and Leukotrienes) As asthma hypersensitivity responses and precipitants are variable and sometimes idiosyncratic- it would...
  5. furion

    best supplements to take after a minor heart attack

    I'm assuming he would now be on the standard stack of; statin, beta-blocker, ACE inhibitor or AR2 receptor blocker and an anti-platelet (or anticoagulant depending on risk factors). Depending on the extent- there is not much that can be done to reverse myocardial hypoxic damage from myocardial...
  6. furion

    O.L. EP1C Unleashed Transdermal vs O.L. EP1C Unleashed

    Shame that paper only tests the solubility of the emulsified complex- the title is actually quite misleading. The oral kinetic profile of epicatechin is seemingly consistent with other polyphenol compounds- characterised by extensive conjugation due to the susceptibility of hydroxyl groups to...
  7. furion

    Potential liver damage from A1M?

    Pruritis (itchy skin) would be more than likely be an earlier symptom. This will often start in the palms and soles of feet. It's worth noting that the severity of the pruritis does not correlate with the manifestations of cholestasis- however it still would most likely be the first red flag...
  8. furion

    vasodilators

    I have used sublingual spray glyceryl trinitrate purely out of curiosity (side note- it's a schedule 3 in Aus- aka doesn't require a script- ie not illegal). As I had predicted it did nothing but make me dizzy for a minute or two and gave me a headache. Nitrate donors like glyceryl trinitrate...
  9. furion

    TUDCA/NAC?

    NAC will only stimulate glutathione synthesis to assist in repleting stores. This mechanism is only of benefit when hepatic glutathione are depleted and glutathione transferase mediated conjugation cannot occur efficiently. What it seems like you are saying is that the compound you are taking...
  10. furion

    Epicatechin

    Although it is interesting, as Jiggz eluded, the relevance of that study on vitamin C (Gomez-Cabrera, et al) can't really be translated to regularly resistant trained men. Hormesis (especially pertaining to ROS in skeletal muscle) is not exactly a finite science- it is very idiosyncratic with...
  11. furion

    7,8-Benzoflavone and GABAergics

    I have yet to see any definitive data that indicates 7'8 Benzoflavone has any direct activity on GABA transmission. It appears to influence chloride channels by activating CFTR and inhibiting stored operated calcium channels- which may explain some of the effects associated with GABA modulation-...
  12. furion

    Epicatechin

    Yes there certainly appears to be evidence suggesting that GSE and xylitol can enhance apical to basolateral absorption of the parent compound (by inhibiting MRP2) however the issue appears to lie with the efficient production of sulphur conjugates in the liver. Megadose vitamin C can...
  13. furion

    Epicatechin

    The pharmacokinetics of epicatechin have been fairly well studied. There appears to be two major obstacles of bioavailability which are pretty much the same as most flavonoid compounds; limited intestinal transport and extensive presystemic metabolism. Although components grape fruit juice can...
  14. furion

    antibiotic on prohormone

    There is no interactions between amoxicillin and methylstenbolone and halodrol- something similar has been discussed in another thread. In short- the kinetics of amoxicillin do not require a degree of hepatic metabolism nor share any common metabolic enzymes or transporter proteins with c-17...
  15. furion

    some questions regarding supplementation of -

    Take your iron with vitamin C 500-1000mg. However if you are aenemic 18mg will take a very long time to correct this- I recommend a supplement containing up to 120mg elemental iron to correct a deficiency. Take your zinc on an empty stomach- split the doses of you get nausea.
  16. furion

    GRHP-2 Thyroid issues? help please

    I would be trying to find out what is causing the abnormalities before fixing them individually. There is a very complex interplay between the pituitary, adrenals, thyroid and testicles- so you might have to be patient and potentially have more tests to identify any pathological cause...
  17. furion

    Who wants a new BLR SERM?!

    I agree with everything in the article and it more or less asserts what I posted previously. In most cases for LnCAP and PC-3 cell lines the AR undergoes mutation- I dare say as this may occur to increase androgen responsiveness as these cancer cells are androgen dependant. Therefore it is far...
  18. furion

    Who wants a new BLR SERM?!

    Yes it is true that DIM is an antiandrogenic- however I find no substantiation associating this with becoming 'weaker and smaller'. The antiandrogenic activity has only been established in LnCAP and PC-3 prostatic cancer cell lines which for the vast majority of cases express mutated androgen...
  19. furion

    Pre cycle bloodwork

    It certainly wouldn't hurt to supplement more b6. The form used in Growth Factor XT is pyridoxal-5-phosphate (P5P)which is essentially what your liver converts most of your supplemented pyroxidine- so taking this form can circumvent this stage of activation. There is no specific scientific...
  20. furion

    Pre cycle bloodwork

    I would say his reluctancy would likely be due to the little association of having a males oestradiol tested under our Medicare system using our therapeutic guidelines- we don't pay for it after all. To be honest, without experiencing high estrogen sides, it's not a huge deal anyway- I would...
Back
Top