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  1. Coop's Corner: Afromamum melegueta and Brown Fat

    Afromamum melegueta – Metabolic Igniter? It’s been a while since my last supplement spotlight, but with the recent flurry of fat burners centered around activating brown fat or converting white fat to brown fat, I figured it’s time for another installment. This relatively new approach has its...

  2. Multi vits - compared

    Shots aren't limited by oral absorption limits

  3. Multi vits - compared

    Forgetting AOR orthocore

  4. Tongkat Ali Dosing- Mr. Cooper or Danes

    Unfortunately, these numbered extracts don't mean a whole lot. The fact that most raw materials suppliers can't even specify what the 200:1 is with respect to (i.e. aqueous, ethanolic, certain compounds, which part of the plant) should tell you that the numbers don't tell much of a story. If you...

  5. Topic of the Week: Better Pre Workout Ingredient?

    It actually has high in vitro binding to the a2 receptor but it's plasma halflife (note: not CNS or tissue) is too short for any appreciable effects to occur. The a2 receptor, which should lower cAMP in vivo, is virtually unaffected in the murine model...in fact, agmatine RAISES cAMP in vivo

  6. Dairy - this stuff the devil?

    One of the worst articles I have ever read on the internet

  7. Epi products?

    I have no reason to believe it would? What spurs your concern?

  8. Epi products?

    Right now, the premise of OL's epi really piques my interest. Phytosomes demonstrate remarkable efficacy, even for the least bioavailable compounds out there. And this is not just at the level of absorption, but at the level of distribution as well. This may very well allow for a longer duration...

  9. Epi products?

    IBS is a disease characterized by no structural changes of the bowel lumen. This means both histology and scoping show ZERO inflammation. Therefore, there is a 0% chance that this is why epicatechin helped him

  10. Coop's Corner #2: L-Norvaline?

    Because citrulline increases eNOS expression as well

  11. GABA-ergic anxiety

    Oh christ, I'm not going to make things personal. All I'm saying is that the anecdote of a few doesn't trump science that is determined by the many (usually trials and meta-analyses of 10,000+ people).

  12. GRAPEFRUIT JUICE AND SUPPS

    For MOST ingredients, grapefruit juice will increase bioavailability and half-life of the compound. It not only inhibits PgP, but it inhibits the CYP system both intestinally (increased absorption of parent compound) and hepatically (decreased metabolism of parent compound). Notable exceptions...

  13. GABA-ergic anxiety

    You haven't worked in many hospitals then. 1st line is a combination of ativan, benadryl, and haldol, and it is virtually foolproof for stopping psychosis or suicidality. And most of the patients who are suicidal on our wards ARE on opiates for pain control anyway. Opiates are a poor choice for...

  14. ABE vs Anafuse

    I think you'll be beyond pleased with your selection ;)

  15. BEST/Favorite BCAA product???

    The leucine content alone makes her statement moot. I am not 99% positive, I am 100% positive the BCAA content is signficantly higher and she is wrong

  16. Curcumin

    Depends how you look at it. If you're rich, you can megadose, and the data on theracumin shows that bioavailability increases substantially with dose (the opposite is true for other forms). So at some point, it's also the bet bang for your buck...it just depends how serious you are about taking...

  17. bp support on cycle

    I can't believe you're endorsing combining the two! There is no responsible way to combine them, hence why this is an ABSOLUTE contraindication in medicine. You need to read up on the mechanics of the synergy anyway, they don't synergize at rest for lowering BP. Rather, nitrates induce reflex...

  18. GABA-ergic anxiety

    CSF sampling, PET/fMRI. Not easily done at all and reserved mostly for research, but we will occasionally use it to diagnose extreme cases of narcolepsy by measuring orexin levels

  19. GABA-ergic anxiety

    Yep, but it's also more than this. Selective b1 blockers like metoprolol DO NOT help anxiety and they are even more effective for lowering heart rate. The true reason propanolol works so well is actually because it is non-selective, and b2 receptors in the brain have a net anxiety-promoting...

  20. Curcumin

    The curcumin with highest bioavailability is theracumin, it beats longvida and meriva head to head, but it's very expensive
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