dontfyourlife
New member
Everyone has their own personal opinion- just giving mine from a research perspective.
If you disagree cool- but before going back to the "Works great for me and I’ve done very extensive experiments with these types of things"
Follow the logic and if you have time check out the research papers- They tend not to be opinions
Basically....Taking oral Anavar tablets and placing them sublingually is not just pointless -it's pharmacologically counterproductive.
Issue 1- Anavar barely dissolves in saliva
Anavar is classified as practically insoluble in water. Sublingual drugs need to rapidly dissolve in the thin layer of saliva under your tongue as that's how it's designed to work.
Unfortunately Anavar tablets are compressed with hard binders like microcrystalline cellulose and magnesium stearate, engineered for GI tract breakdown- not for rapid dissolution in a less than of a milliliter of saliva that is in your mouth.
Sublingual tablet design requires drugs to have biphasic solubility. Which in plain English is high enough lipid solubility to cross the mucosa, but... also enough water solubility to dissolve in your limited amount of saliva first.
Smashing a tablet to chalk like consistency doesn't come close to the above.
Issue 2- Dosing becomes less effective
Sublingual delivery depends heavily on the drug not being swallowed in saliva before absorption is complete.
Drug makers designing "real" sublingual tablets have clear instructions on the packaging to avoid swallowing saliva during administration- because even that compromises absorption.
With a standard Anavar tablet that doesn't dissolve quickly you're inevitably swallowing chalky particles and drug loaded saliva the entire time. Ironically routing it right back through the GI tract. (except without the protective coatings needed to not get destroyed in the GI tract)
Congrats.....you just created a way less effective version of swallowing the pill in the first place.
Show me the Money- Or the science
Now this is copied/pasted from the research paper
For a drug to work sublingually, all of the following must be met:
In other words by doing the crush/dissolve method you are significantly reducing your effective dose by removing the very mechanism the tablet was designed for.
Or..... Just swallow the [explicit] pill
Sources: Innovare Academic Sciences (IJCPR, 2017) · Pharmaceutical Technology · INCHEM PIM 913 · PubMed 21764219
If you disagree cool- but before going back to the "Works great for me and I’ve done very extensive experiments with these types of things"
Follow the logic and if you have time check out the research papers- They tend not to be opinions
Basically....Taking oral Anavar tablets and placing them sublingually is not just pointless -it's pharmacologically counterproductive.
Issue 1- Anavar barely dissolves in saliva
Anavar is classified as practically insoluble in water. Sublingual drugs need to rapidly dissolve in the thin layer of saliva under your tongue as that's how it's designed to work.
Unfortunately Anavar tablets are compressed with hard binders like microcrystalline cellulose and magnesium stearate, engineered for GI tract breakdown- not for rapid dissolution in a less than of a milliliter of saliva that is in your mouth.
Sublingual tablet design requires drugs to have biphasic solubility. Which in plain English is high enough lipid solubility to cross the mucosa, but... also enough water solubility to dissolve in your limited amount of saliva first.
Smashing a tablet to chalk like consistency doesn't come close to the above.
Issue 2- Dosing becomes less effective
Sublingual delivery depends heavily on the drug not being swallowed in saliva before absorption is complete.
Drug makers designing "real" sublingual tablets have clear instructions on the packaging to avoid swallowing saliva during administration- because even that compromises absorption.
With a standard Anavar tablet that doesn't dissolve quickly you're inevitably swallowing chalky particles and drug loaded saliva the entire time. Ironically routing it right back through the GI tract. (except without the protective coatings needed to not get destroyed in the GI tract)
Congrats.....you just created a way less effective version of swallowing the pill in the first place.
Show me the Money- Or the science
Now this is copied/pasted from the research paper
For a drug to work sublingually, all of the following must be met:
- Sublingual epithelium thin enough for passive diffusion (100–200 μm)
- Slightly higher lipophilicity than required for GI absorption
- Unionized state at salivary pH (~6.0)
- Favorable oil-to-water partition coefficient (range: 40–2,000)
- Adequate water solubility to dissolve in saliva first
- Must not bind excessively to oral mucosa — binding traps the drug rather than allowing systemic absorption
In other words by doing the crush/dissolve method you are significantly reducing your effective dose by removing the very mechanism the tablet was designed for.
Or..... Just swallow the [explicit] pill
Sources: Innovare Academic Sciences (IJCPR, 2017) · Pharmaceutical Technology · INCHEM PIM 913 · PubMed 21764219
