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Anti-aging NAD+ and other supplements.

DaveMcNaul

DaveMcNaul

Member
Nowadays we have access to a huge amount of information—but that same information can also lead to confusion and even misinformation.

Some people claim that NMN has to be injected because the digestive process may degrade part of it, while others say it can still be effective when taken orally. In reality, oral NMN appears to be absorbed and can raise NAD+ levels, although the exact efficiency and mechanisms are still being studied. In the end, it’s hard to know which direction to take.

Is it really necessary to focus on cellular health from an anti-aging perspective?

Until not long ago, people followed a simpler approach—using compounds like NAC, glycine, resveratrol, etc. But since NAD+ became a major focus, it naturally raises the question of whether it’s actually possible to improve healthspan or even extend lifespan using NAD+ precursors.

From a scientific standpoint, NAD+ precursors such as NMN and NR have shown promising effects in animal studies and can increase NAD+ levels in humans. However, strong evidence that they significantly extend lifespan or produce meaningful long-term anti-aging effects in humans is still limited.

Can anyone shed some light on this topic? Any personal experiences or evidence
suggesting real, positive effects on health?
 
Very well said about the huge amount of information. I think that information overload can sometimes make things more confusing and the way that advertising works now, its hard to know what's real information and what's paid advertising/content now days.

I'm going to put the things that you wrote in red and reply to them point by point.

Some people claim that NMN has to be injected because the digestive process may degrade part of it, while others say it can still be effective when taken orally.

I don't think that NMN has to be injected. I think that there's just simply too much feedback on oral NMN use for that to be the case. I think that oral use is fine and that its like most things, you may only absorb ___% but you simply adjust the dose accordingly to compensate for that.

Is it really necessary to focus on cellular health from an anti-aging perspective?

I think that what is 'necessary' depends on the individual and their desired goals.

I do think that cellular health is an important aspect of healthy aging, but I think that there are more facets to healthy aging than some people or brands make it out to me - meaning that I think there is a lot more to the subject than just NMN, NR, NAD+, etc.

Until not long ago, people followed a simpler approach—using compounds like NAC, glycine, resveratrol, etc. But since NAD+ became a major focus, it naturally raises the question of whether it’s actually possible to improve healthspan or even extend lifespan using NAD+ precursors.

I think that people have always tried to use the best cutting edge concepts they had access to at the time to a degree, but information and knowledge continues to grow and build. I remember when NAC and Resveratrol were considered new and cutting edge, now they seem bland even though they are still very relevant.

I don't think anyone can really say that something can improve lifespan, simply because there are just too many ways that a person can die. You could target mitochondrial health, telomere lengthening, senescent cell clearance, and still drop dead from a stroke, aneurism, get cancer from an unknown environmental toxin, a genetic condition, etc.

So I think of 'anti-aging' is what under perfect circumstances could improve lifespan from the particular avenue that we are looking at in the absence of other things going wrong.

That's why I prefer to think of it as Healthy Aging & Longevity with an emphasis on improving quality of life.

But yes, I think that NAD/MNM supplements do have a place and role in this, but that they are overhyped and should be incorporated as part of an overall approach.

From a scientific standpoint, NAD+ precursors such as NMN and NR have shown promising effects in animal studies and can increase NAD+ levels in humans. However, strong evidence that they significantly extend lifespan or produce meaningful long-term anti-aging effects in humans is still limited.

I was going to type out more to this and then realized it was kind of redundant to what I typed in the above part.
 
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I've read up on NMN and seems like it is a waste of money to me. If you're worried about longevity, there are so many other things to focus on ie, sleep, nutrition. Spend a little more money for organic food. Hell, spend it on going to a happy hour once a month. Studies show people live longer who are more socially connected.

I do take Glucovantage and Taurine. They seem to have some longevity benefits as well as many other benefits. I do not take them for longevity specifically.

Sorry, but longevity supplements seem like a crapshoot to me.
 
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I look at anti-aging supps as a way to improve life quality as we age. Will they extend my lifespan? Perhaps, but I'm not assuming they alone will. I do however feel a higher quality life allows you to do more, which in turn could improve your lifespan.

If you're really curious about NMN, I would order a 100g bag from ProHealth and run 1g a day until you run out. 3months on should be enough to access if it's doing something for you.

My personal exp is I feel increasing my NAD+ has improved the efficiency of other supps I take and has helped get some new gains, which I was not expecting. Probably tied to the better recovery. I can sleep 4-6hrs and feel like I got more. So when I get 7-8, I think it's better recovery than I had before the NMN.
 
@Danksta710 interesting feedback. I've been on the fence about trying it, but I guess that's a good way to do it.

I take 1gr niacinimide daily (for precancerous lesions), so I wonder what effect this has in that same vein.
 
I'm sure most of you have heard of Bryan Johnson whose slogan is literally Don't Die. He tries everything on himself and meticulously measures every biomarker before and after. I'd follow him if you want to go down the anti aging rabbit hole.
 
rodefeeh said:
I'm sure most of you have heard of Bryan Johnson whose slogan is literally Don't Die. He tries everything on himself and meticulously measures every biomarker before and after. I'd follow him if you want to go down the anti aging rabbit hole.
Click to expand...

What I want to do regularly is UV light during winter and maybe red light the whole year? I don’t know but this last winter was so bad and mental health is so important for being healthy in general.
 
rodefeeh said:
I'm sure most of you have heard of Bryan Johnson whose slogan is literally Don't Die. He tries everything on himself and meticulously measures every biomarker before and after. I'd follow him if you want to go down the anti aging rabbit hole.
Click to expand...

His recent frog venom trip was fun to read about haha.
 
poison said:
@Danksta710 interesting feedback. I've been on the fence about trying it, but I guess that's a good way to do it.

I take 1gr niacinimide daily (for precancerous lesions), so I wonder what effect this has in that same vein.
Click to expand...

I take that too for skin health. I also take nicotinamide as well. Just my personal opinion, I like taking multiple NAD precursors since they all work slightly different from each other.
 
I just started watching this podcast. I saw a snippet where the Harvard professor says he takes NMN. He also takes resveratrol, metformin/berberine, spermidine, glycine, Vit D + K2, and low-dose aspirin/niacin for his high Lp(a) which I have too. I tried niacin for a while and just couldn't get past the extreme flushing.

 
rodefeeh said:
I just started watching this podcast. I saw a snippet where the Harvard professor says he takes NMN. He also takes resveratrol, metformin/berberine, spermidine, glycine, Vit D + K2, and low-dose aspirin/niacin for his high Lp(a) which I have too. I tried niacin for a while and just couldn't get past the extreme flushing.

Click to expand...
Nice video, thanks!

I’m just taking spermidine and vit d k2.

I think I’ll start using NMN when I turn 43-44.
 
poison said:
Anyone tried methylene blue?
Click to expand...
Good discussion on it here
Smont

Thread 'Methylene Blue'

I'm getting ready to start Methylene Blue. Here's some of the main reasons I am interested and my goals in using it. I will eventually post a link to my random training log And that's where I will be updating results. I have to assume it's going to take a long Time to see results for some of these things and then other things should be noticeable almost immediately.

Take the following with a grain of salt as there are millions of things listed that this product does I'm just pointing out the things that caught my attention and the reasons why I'm interested in using them.

Methylene...
  • Like
  • Love
 
rodefeeh said:
Good discussion on it here
Smont

Thread 'Methylene Blue'

I'm getting ready to start Methylene Blue. Here's some of the main reasons I am interested and my goals in using it. I will eventually post a link to my random training log And that's where I will be updating results. I have to assume it's going to take a long Time to see results for some of these things and then other things should be noticeable almost immediately.

Take the following with a grain of salt as there are millions of things listed that this product does I'm just pointing out the things that caught my attention and the reasons why I'm interested in using them.

Methylene...
  • Like
  • Love
Click to expand...

Thanks! I read through that yesterday. Kinda unsure on that one.
 
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