I only just started using the PM system myself and that is why I did not even notice that you sent this message until now. I do not believe that my problem is autoimmune and I think from more recent postings about my skin you probably realize this is a different animal from Crohns. I also posted that I do not have elevated IgE or responses mediated by this that I am aware of so it seems less likely that histamine release is a significant part of my problems. I do ,however, have chronic rhinitis. Nevertheless, I did pay attention to your post about HISTAME and thought it worth trying anyway - you never really know. At the moment I am continuing my trial with Xylitol for a while before I try something new. I do not have problems with stomach acid but at one time for other reasons I tried Tagament for a short while. It certainly did not help me but I don't recall if it made anything worse either.