In some individuals it does, but not all. It doesn't inhibit the absorbtion of fat, you just have to make sure your getting healthy dietary fat elsewhere throughout the day. So if you took 2 grams of fish oil or a tsp olive oil in whatever you cooked with the olestra you would be fine. I just think this would be great to do more with it than just chips, because thats all they use it for. I would like to make some chicken nuggets once in a while with real chicken breasts. It would be nice to make it with the Olestra. There is so much you could do with it, would be a great stack with Sesalean. Get on it Dsade, work your magic!